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Lund University

EducationLund, Sweden
About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.


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Journal ArticleDOI
TL;DR: In this article, a coupled carbon and water flux model is used to calculate, for each PFT, the leaf area index (LAI) that maximizes net primary production (NPP), subject to the constraint that NPP must be sufficient to maintain this LAI.
Abstract: The equilibrium terrestrial biosphere model BIOME3 simulates vegetation distribution and biogeochemistry, and couples vegetation distribution directly to biogeochemistry. Model inputs consist of latitude, soil texture class, and monthly climate (temperature, precipitation, and sunshine) data on a 0.5 degrees grid. Ecophysiological constraints determine which plant functional types (PFTs) may potentially occur. A coupled carbon and water flux model is then used to calculate, for each PFT, the leaf area index (LAI) that maximizes net primary production (NPP), subject to the constraint that NPP must be sufficient to maintain this LAI. Competition between PFTs is simulated by using the optimal NPP of each PFT as an index of competitiveness, with additional rules to approximate the dynamic equilibrium between natural disturbance and succession driven by light competition. Model output consists of a quantitative vegetation state description in terms of the dominant PFT, secondary PFTs present, and the total LAI and NPP for the ecosystem. Canopy conductance is treated as a function of the calculated optimal photosynthetic rate and water stress. Regional evapotranspiration is calculated as a function of canopy conductance, equilibrium evapotranspiration rate, and soil moisture using a simple planetary boundary layer parameterization. This scheme results in a two-way coupling of the carbon and water fluxes through canopy conductance, allowing simulation of the response of photosynthesis, stomatal conductance, and leaf area to environmental factors including atmospheric CO2. Comparison with the mapped distribution of global vegetation shows that the model successfully reproduces the broad-scale patterns in potential natural vegetation distribution. Comparison with NPP measurements, and with an FPAR (fractional absorbed photosynthetically active radiation) climatology based on remotely sensed greenness measurements, provides further checks on the model's internal logic. The model is envisaged as a tool for integrated analysis of the impacts of changes in climate and CO2 on ecosystem structure and function. (Less)

971 citations

Journal ArticleDOI
01 Dec 2004-Diabetes
TL;DR: It is concluded that the high-fat diet-fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment.
Abstract: This study characterizes the high-fat diet-fed mouse as a model for impaired glucose tolerance (IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58% energy by fat) or a normal diet (11% fat). Body weight was higher in mice fed the high-fat diet already after the first week, due to higher dietary intake in combination with lower metabolic efficiency. Circulating glucose increased after 1 week on high-fat diet and remained elevated at a level of approximately 1 mmol/l throughout the 12-month study period. In contrast, circulating insulin increased progressively by time. Intravenous glucose challenge revealed a severely compromised insulin response in association with marked glucose intolerance already after 1 week. To illustrate the usefulness of this model for the development of new treatment, mice were fed an orally active inhibitor of dipeptidyl peptidase-IV (LAF237) in the drinking water (0.3 mg/ml) for 4 weeks. This normalized glucose tolerance, as judged by an oral glucose tolerance test, in association with augmented insulin secretion. We conclude that the high-fat diet-fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment.

966 citations

Journal ArticleDOI
Geirid Fiskesjö1
TL;DR: The Allium test is a short-term test with many advantages: low cost, ease to handle, good chromosome conditions for the study of chromosome damage or disturbance of cell division including the evaluation of risks of aneuploidy.
Abstract: The Allium test is suggested as a standard in environmental monitoring, e. g. as a part of a test battery. Background, the method including suggested parameters for standard use, results from various application areas and comparisons with a number of other test systems are presented. The Allium test is a short-term test with many advantages: low cost, ease to handle, good chromosome conditions for the study of chromosome damage or disturbance of cell division including the evaluation of risks of aneuploidy. The ability of the root cells to activate promutagens (the MFO-system) further widens the application areas of the Allium test. The use of series of onions for each concentration of the test chemical allows statistical considerations, and from growth curves Effect-Concentration values are obtained. The Allium test is, lastly, a sensitive test showing good correlation to other test systems. Thus, positive results in the Allium test should be considered as a warning and also an indication that the tested chemical may be a risk to human health and to our environment.

966 citations

Journal ArticleDOI
Heike Rauer1, Heike Rauer2, C. Catala3, Conny Aerts4  +164 moreInstitutions (51)
TL;DR: The PLATO 2.0 mission as discussed by the authors has been selected for ESA's M3 launch opportunity (2022/24) to provide accurate key planet parameters (radius, mass, density and age) in statistical numbers.
Abstract: PLATO 2.0 has recently been selected for ESA’s M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental questions such as: How do planetary systems form and evolve? Are there other systems with planets like ours, including potentially habitable planets? The PLATO 2.0 instrument consists of 34 small aperture telescopes (32 with 25 s readout cadence and 2 with 2.5 s candence) providing a wide field-of-view (2232 deg 2) and a large photometric magnitude range (4–16 mag). It focusses on bright (4–11 mag) stars in wide fields to detect and characterize planets down to Earth-size by photometric transits, whose masses can then be determined by ground-based radial-velocity follow-up measurements. Asteroseismology will be performed for these bright stars to obtain highly accurate stellar parameters, including masses and ages. The combination of bright targets and asteroseismology results in high accuracy for the bulk planet parameters: 2 %, 4–10 % and 10 % for planet radii, masses and ages, respectively. The planned baseline observing strategy includes two long pointings (2–3 years) to detect and bulk characterize planets reaching into the habitable zone (HZ) of solar-like stars and an additional step-and-stare phase to cover in total about 50 % of the sky. PLATO 2.0 will observe up to 1,000,000 stars and detect and characterize hundreds of small planets, and thousands of planets in the Neptune to gas giant regime out to the HZ. It will therefore provide the first large-scale catalogue of bulk characterized planets with accurate radii, masses, mean densities and ages. This catalogue will include terrestrial planets at intermediate orbital distances, where surface temperatures are moderate. Coverage of this parameter range with statistical numbers of bulk characterized planets is unique to PLATO 2.0. The PLATO 2.0 catalogue allows us to e.g.: - complete our knowledge of planet diversity for low-mass objects, - correlate the planet mean density-orbital distance distribution with predictions from planet formation theories,- constrain the influence of planet migration and scattering on the architecture of multiple systems, and - specify how planet and system parameters change with host star characteristics, such as type, metallicity and age. The catalogue will allow us to study planets and planetary systems at different evolutionary phases. It will further provide a census for small, low-mass planets. This will serve to identify objects which retained their primordial hydrogen atmosphere and in general the typical characteristics of planets in such low-mass, low-density range. Planets detected by PLATO 2.0 will orbit bright stars and many of them will be targets for future atmosphere spectroscopy exploring their atmosphere. Furthermore, the mission has the potential to detect exomoons, planetary rings, binary and Trojan planets. The planetary science possible with PLATO 2.0 is complemented by its impact on stellar and galactic science via asteroseismology as well as light curves of all kinds of variable stars, together with observations of stellar clusters of different ages. This will allow us to improve stellar models and study stellar activity. A large number of well-known ages from red giant stars will probe the structure and evolution of our Galaxy. Asteroseismic ages of bright stars for different phases of stellar evolution allow calibrating stellar age-rotation relationships. Together with the results of ESA’s Gaia mission, the results of PLATO 2.0 will provide a huge legacy to planetary, stellar and galactic science.

965 citations

Journal ArticleDOI
TL;DR: The Greenland Ice Core Chronology 2005 (GICC05) as discussed by the authors is a time scale based on annual layer counting of high-resolution records from Greenland ice cores, which continuously covers the past 60 ka.
Abstract: . The Greenland Ice Core Chronology 2005 (GICC05) is a time scale based on annual layer counting of high-resolution records from Greenland ice cores. Whereas the Holocene part of the time scale is based on various records from the DYE-3, the GRIP, and the NorthGRIP ice cores, the glacial part is solely based on NorthGRIP records. Here we present an 18 ka extension of the time scale such that GICC05 continuously covers the past 60 ka. The new section of the time scale places the onset of Greenland Interstadial 12 (GI-12) at 46.9±1.0 ka b2k (before year AD 2000), the North Atlantic Ash Zone II layer in GI-15 at 55.4±1.2 ka b2k, and the onset of GI-17 at 59.4±1.3 ka b2k. The error estimates are derived from the accumulated number of uncertain annual layers. In the 40–60 ka interval, the new time scale has a discrepancy with the Meese-Sowers GISP2 time scale of up to 2.4 ka. Assuming that the Greenland climatic events are synchronous with those seen in the Chinese Hulu Cave speleothem record, GICC05 compares well to the time scale of that record with absolute age differences of less than 800 years throughout the 60 ka period. The new time scale is generally in close agreement with other independently dated records and reference horizons, such as the Laschamp geomagnetic excursion, the French Villars Cave and the Austrian Kleegruben Cave speleothem records, suggesting high accuracy of both event durations and absolute age estimates.

965 citations


Authors

Showing all 42777 results

NameH-indexPapersCitations
Yi Chen2174342293080
Fred H. Gage216967185732
Kari Stefansson206794174819
Mark I. McCarthy2001028187898
Ruedi Aebersold182879141881
Jie Zhang1784857221720
Feng Zhang1721278181865
Martin G. Larson171620117708
Michael Snyder169840130225
Unnur Thorsteinsdottir167444121009
Anders Björklund16576984268
Carl W. Cotman165809105323
Dennis R. Burton16468390959
Jaakko Kaprio1631532126320
Panos Deloukas162410154018
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023246
2022698
20216,295
20206,032
20195,584
20185,249