Lund University

About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.

Elemental abundance trends in the Galactic thin and thick disks as traced by nearby F and G dwarf stars

Abstract: Based on spectra from F and G dwarf stars, we present elementalabundance trends in the Galactic thin and thick disks in the metallicityregime -0.8< [Fe/H < +0.4. Our findings can besummarized as follows. 1) Both the thin and the thick disks show smoothand distinct abundance trends that, at sub-solar metallicities, areclearly separated. 2) For the alpha -elements the thick disk showssignatures of chemical enrichment from SNe type Ia. 3) The age of thethick disk sample is in the mean older than the thin disk sample. 4)Kinematically, there exist thick disk stars with super-solarmetallicities. Based on these findings, together with other constraintsfrom the literature, we discuss different formation scenarios for thethick disk. We suggest that the currently most likely formation scenariois a violent merger event or a close encounter with a companion galaxy.Based on kinematics the stellar sample was selected to contain starswith high probabilities of belonging either to the thin or to the thickGalactic disk. The total number of stars are 66 of which 21 belong tothe thick disk and 45 to the thin disk. The analysis is based onhigh-resolution spectra with high signal-to-noise (R 48 000 and S/Ngtrsim 150, respectively) recorded with the FEROS spectrograph on LaSilla, Chile. Abundances have been determined for four alpha -elements(Mg, Si, Ca, and Ti), for four even-nuclei iron peak elements (Cr, Fe,Ni, and Zn), and for the light elements Na and Al, from equivalent widthmeasurements of 30 000 spectral lines. An extensive investigation ofthe atomic parameters, log gf-values in particular, have been performedin order to achieve abundances that are trustworthy. Noteworthy is thatwe find for Ti good agreement between the abundances from Ti I and TiIi. Our solar Ti abundances are in concordance with the standardmeteoritic Ti abundanceBased on observations collected at the European Southern Observatory, LaSilla, Chile, Proposals #65.L-0019(B) and 67.B-0108(B).Full Tables eftab:linelist and eftab:abundances are onlyavailable in electronic form at the CDS via anonymous ftp tocdsarc.u-strasbg.fr (130.79.128.5) or viahttp://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/410/527 (Less)

Interleukin-2–Receptor Blockade with Daclizumab to Prevent Acute Rejection in Renal Transplantation

Abstract: Background Monoclonal antibodies that block the high-affinity interleukin-2 receptor expressed on alloantigen-reactive T lymphocytes may cause selective immunosuppression. Daclizumab is a genetically engineered human IgG1 monoclonal antibody that binds specifically to the α chain of the interleukin-2 receptor and may thus reduce the risk of rejection after renal transplantation. Methods We administered daclizumab (1.0 mg per kilogram of body weight) or placebo intravenously before transplantation and once every other week afterward, for a total of five doses, to 260 patients receiving first cadaveric kidney grafts and immunosuppressive therapy with cyclosporine, azathioprine, and prednisone. The patients were followed at regular intervals for 12 months. The primary end point was the incidence of biopsy-confirmed acute rejection within six months after transplantation. Results Of the 126 patients given daclizumab, 28 (22 percent) had biopsy-confirmed episodes of acute rejection, as compared with 47 of the ...

Representation of vegetation dynamics in the modelling of terrestrial ecosystems: comparing two contrasting approaches within European climate space

Abstract: 1 Advances in dynamic ecosystem modelling have made a number of different approaches to vegetation dynamics possible. Here we compare two models representing contrasting degrees of abstraction of the processes governing dynamics in real vegetation. 2 Model (a) (GUESS) simulates explicitly growth and competition among individual plants. Differences in crown structure (height, depth, area and LAI) influence relative light uptake by neighbours. Assimilated carbon is allocated individually by each plant to its leaf, fine root and sapwood tissues. Carbon allocation and turnover of sapwood to heartwood in turn govern height and diameter growth. 3 Model (b) (LPJ) incorporates a ‘dynamic global vegetation model’ (DGVM) architecture, simulating growth of populations of plant functional types (PFTs) over a grid cell, integrating individual-level processes over the proportional area (foliar projective cover, FPC) occupied by each PFT. Individual plants are not simulated, but are replaced by explicit parameterizations of their growth and interactions. 4 The models are identical in their representation of core physiological and biogeochemical processes. Both also use the same set of PFTs, corresponding to the major woody plant groups in Europe, plus a grass type. 5 When applied at a range of locations, broadly spanning climatic variation within Europe, both models successfully predicted PFT composition and succession within modern natural vegetation. However, the individual-based model performed better in areas where deciduous and evergreen types coincide, and in areas subject to pronounced seasonal water deficits, which would tend to favour grasses over drought-intolerant trees. 6 Differences in model performance could be traced to their treatment of individual-level processes, in particular light competition and stress-induced mortality. 7 Our results suggest that an explicit individual-based approach to vegetation dynamics may be an advantage in modelling of ecosystem structure and function at the resolution required for regional- to continental-scale studies.

Autonomic regulation of islet hormone secretion--implications for health and disease.

Abstract: The pancreatic islets are richly innervated by parasympathetic, sympathetic and sensory nerves. Several different neurotransmitters are stored within the terminals of these nerves, both the classical neurotransmitters, acetylcholine and noradrenaline, and several neuropeptides. The neuropeptides, vasoactive intestinal polypeptide, pituitary adenlyate cyclase activating polypeptide and gastrin releasing peptide are constituents of the parasympathetic nerves, whereas the neuropeptides galanin and neuropeptide Y are localised to sympathetic nerve terminals. Furthermore, the neuropeptide calcitonin gene-related peptide is localised to sensory nerves and cholecystokinin is also an islet neuropeptide, although the nature of the cholecystokinin nerves is not established. Stimulation of the autonomic nerves and treatment with neurotransmitters affect islet hormone secretion. Thus, insulin secretion is stimulated by parasympathetic nerves or their neurotransmitters and inhibited by sympathetic nerves or their neurotransmitters. The islet autonomic nerves seem to be of physiological importance in mediating the cephalic phase of insulin secretion, in synchronising the islets to function as a unit allowing oscillations of islet hormone secretion, and in optimising islet hormone secretion during metabolic stress, e.g. hypoglycaemia and neuroglycopenia. The autonomic nerves could also be involved in the islet adaptation to insulin resistance with possible implication for the development of glucose intolerance and Type II (non-insulin-dependent) diabetes mellitus. It is concluded that islet innervation, through the contribution of all branches of the autonomic nerves and several different neurotransmitters is of importance both for the physiology and pathophysiology of the islets.