Showing papers by "Maastricht University published in 2022"
TL;DR: In this article , causal, multi-target signaling modules are defined to explain disease phenotypes and their respective comorbidities, and effective therapeutic intervention is achieved by synergistic multicompound network pharmacology and drug repurposing.
134 citations
Dalhousie University1, University of Amsterdam2, Koç University3, Max Planck Society4, University of Basel5, Maastricht University6, Cardiff University7, University College Cork8, King's College London9, RMIT University10, Leiden University Medical Center11, University of Freiburg12, Istituto Superiore di Sanità13
TL;DR: This article provided a critical overview on how the COVID-19 pandemic has impacted mental health and how human stress resilience has been shaped by the pandemic on the shorter and longer term.
123 citations
Konstantinos N. Fountoulakis1, Grigorios N Karakatsoulis1, Seri Abraham2, Kristina Adorjan +153 more•Institutions (62)
TL;DR: In this article, the effects of the COVID-19 pandemic on mental health were investigated and the final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress.
53 citations
TL;DR: The 15th Dresden Symposium on Autoantibodies as discussed by the authors was focused on auto-immunity in the SARS-CoV-2 era, and a collection and distillation of the topics presented at this meeting was presented.
41 citations
TL;DR: This paper found that distrust of institutions reduces trust between strangers, within-group cooperation, commitment, and prosocial behavior, and increases prejudice, intergroup conflict, polarization, and extremism, and concluded that institutional distrust and conspiracy theories erode the fabric of society.
Abstract: Many citizens distrust powerful societal institutions, and hold conspiracy theories about them. What are the implications of this suspicion of institutions for people’s social relationships? The current paper proposes that institutions have at least two functions to regulate citizens’ social relationships: providing people with a sense of safety, and providing models for group norms and values. Suspicion of institutions undermines both of these functions, and therefore yields a range of negative societal outcomes by impacting people’s interpersonal, within-group, and between-group relationships. More specifically, suspicion of institutions reduces trust between strangers, within-group cooperation, commitment, and prosocial behavior, and increases prejudice, intergroup conflict, polarization, and extremism. We conclude that institutional distrust and conspiracy theories erode the fabric of society.
39 citations
TL;DR: This paper found that distrust of institutions reduces trust between strangers, within-group cooperation, commitment, and prosocial behavior, and increases prejudice, intergroup conflict, polarization, and extremism, and concluded that institutional distrust and conspiracy theories erode the fabric of society.
Abstract: Many citizens distrust powerful societal institutions, and hold conspiracy theories about them. What are the implications of this suspicion of institutions for people's social relationships? The current paper proposes that institutions have at least two functions to regulate citizens' social relationships: providing people with a sense of safety, and providing models for group norms and values. Suspicion of institutions undermines both of these functions, and therefore yields a range of negative societal outcomes by impacting people's interpersonal, within-group, and between-group relationships. More specifically, suspicion of institutions reduces trust between strangers, within-group cooperation, commitment, and prosocial behavior, and increases prejudice, intergroup conflict, polarization, and extremism. We conclude that institutional distrust and conspiracy theories erode the fabric of society.
37 citations
TL;DR: The most popular measurement method was rules of thumb, followed by life-cycle assessment (LCA) or LCA-based tools as discussed by the authors, while most participants measure the impact of their current business models, they do not forecast the future impacts of their circular business ideas before implementation.
28 citations
TL;DR: In this article, the paradigm change from one-size-fits-all psychiatry to more personalized-psychiatry, where they distinguish between "precision psychiatry" and "stratified psychiatry".
26 citations
TL;DR: In this paper , the effect of age and comorbidities on the relation of age with the primary outcome was evaluated using mediation analysis, and the impact of age was attenuated after age-spline adjustment, only leaving female sex, diabetes mellitus, chronic kidney disease, and chronic pulmonary obstructive disease (COPD) significantly associated.
Abstract: Abstract Background Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which comorbidities mediate the impact of age remains unknown. Methods In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven COVID-19 patients hospitalized in Dutch hospitals (between February and July 2020) from the CAPACITY-COVID registry were included (age 69[58–77]years, 64% men). The primary outcome was defined as a combination of in-hospital mortality or discharge with palliative care. Logistic regression analysis was performed to analyze the associations between sex, age, and comorbidities with the primary outcome. The effect of comorbidities on the relation of age with the primary outcome was evaluated using mediation analysis. Results In-hospital COVID-19 related mortality occurred in 1108 (23%) patients, 836 (76%) were aged ≥70 years (70+). Both age 70+ and female sex were univariably associated with outcome (odds ratio [OR]4.68, 95%confidence interval [4.02–5.45], OR0.68[0.59–0.79], respectively;both p < 0.001). All comorbidities were univariably associated with outcome ( p <0.001), and all but dyslipidemia remained significant after adjustment for age70+ and sex. The impact of comorbidities was attenuated after age-spline adjustment, only leaving female sex, diabetes mellitus (DM), chronic kidney disease (CKD), and chronic pulmonary obstructive disease (COPD) significantly associated (female OR0.65[0.55–0.75], DM OR1.47[1.26–1.72], CKD OR1.61[1.32–1.97], COPD OR1.30[1.07–1.59]). Pre-existing comorbidities in older patients negligibly (<6% in all comorbidities) mediated the association between higher age and outcome. Conclusions Age is the main determinant of COVID-19 related in-hospital mortality, with negligible mediation effect of pre-existing comorbidities. Trial registration CAPACITY-COVID ( NCT04325412 )
26 citations
TL;DR: An overview of the current and developing regenerative medicine therapies to treat corneal endothelial disease and providing the necessary guidance and understanding towards the treatment of CORNEAL ENThelial disease is provided in this article .
21 citations
TL;DR: In this article , the authors show that the rate of cellular fatty acid uptake is short-term (i.e., minutes) regulated by the subcellular recycling of CD36 between endosomes and the plasma membrane, which is governed by the activity of vacuolar-type H+-ATPase.
Abstract: Transmembrane glycoprotein cluster of differentiation 36 (CD36) is a scavenger receptor class B protein (SR-B2) that serves various functions in lipid metabolism and signaling, in particular facilitating the cellular uptake of long-chain fatty acids. Recent studies have disclosed CD36 to play a prominent regulatory role in cellular fatty acid metabolism in both health and disease.The rate of cellular fatty acid uptake is short-term (i.e., minutes) regulated by the subcellular recycling of CD36 between endosomes and the plasma membrane. This recycling is governed by the activity of vacuolar-type H+-ATPase (v-ATPase) in the endosomal membrane via assembly and disassembly of two subcomplexes. The latter process is being influenced by metabolic substrates including fatty acids, glucose and specific amino acids, together resulting in a dynamic interplay to modify cellular substrate preference and uptake rates. Moreover, in cases of metabolic disease v-ATPase activity was found to be affected while interventions aimed at normalizing v-ATPase functioning had therapeutic potential.The emerging central role of CD36 in cellular lipid homeostasis and recently obtained molecular insight in the interplay among metabolic substrates indicate the applicability of CD36 as target for metabolic modulation therapy in disease. Experimental studies already have shown the feasibility of this approach.
TL;DR: The authors discuss theories of norm internalization, social and self-image concerns, and social learning, and present two behavioral, incentivized tasks that can be used to elicit norms and measure the individual propensity to follow them.
Abstract: Norms prescribe how to make decisions in social situations and play a crucial role in sustaining cooperative relationships and coordinating collective action. However, following norms often requires restricting behavior, demanding to curtail selfishness, or suppressing personal goals. This raises the question why people adhere to norms. We review recent theories and empirical findings that aim at explaining why people follow norms even in private, when violations are difficult to detect and are not sanctioned. We discuss theories of norm internalization, social and self-image concerns, and social learning (i.e. preferences conditional on what others do/believe). Finally, we present two behavioral, incentivized tasks that can be used to elicit norms and measure the individual propensity to follow them.
TL;DR: In this paper, the authors evaluated the usefulness and effectiveness of three mediums (text, images, and stylistic features) for three products (orange juice, muesli bar, plain yogurt) and found that stylistic elements had a positive effect for sensory appeal but tended to have negative effects for environmental aspects.
TL;DR: Wang et al. as discussed by the authors found that the most striking cross-cultural differences concerned perceived socioeconomic benefits of beauty (mainly Chinese women) and women's conceptualization of body appreciation.
TL;DR: An algorithm for regression analysis that addresses features typical for big data sets, which is called “sparse shooting S”, meaning that many of the regression coefficients are set to zero, hereby selecting the most relevant predictors.
University College London1, University of Utah2, University Medical Center Groningen3, Yale University4, Imperial College London5, Technische Universität München6, University of Bologna7, University of Lisbon8, Innsbruck Medical University9, National and Kapodistrian University of Athens10, Mayo Clinic11, James Cook University12, Cornell University13, University of Texas Health Science Center at Houston14, University of Patras15, AHEPA University Hospital16, Maastricht University17, St George's, University of London18, University of Porto19, University of Nicosia20, Ljubljana University Medical Centre21, University of Poitiers22, New York University23, University Hospital Heidelberg24, University of Miami25, University of Regensburg26, Marche Polytechnic University27, Università Campus Bio-Medico28, National University of Ireland, Galway29, University of Maryland, Baltimore30
TL;DR: In this paper, a literature review was performed with a focus on data from recent studies and several clinical and imaging high-risk features have been identified that are associated with an increased long-term ipsilateral ischemic stroke risk in patients with carotid stenosis.
Abstract: Objectives The recommendations of international guidelines for the management of asymptomatic carotid stenosis (ACS) often vary considerably and extend from a conservative approach with risk factor modification and best medical treatment (BMT) alone, to a more aggressive approach with a carotid intervention plus BMT. The aim of the current multispecialty position statement is to reconcile the conflicting views on the topic. Materials and methods A literature review was performed with a focus on data from recent studies. Results Several clinical and imaging high-risk features have been identified that are associated with an increased long-term ipsilateral ischemic stroke risk in patients with ACS. Such high-risk clinical/imaging features include intraplaque hemorrhage, impaired cerebrovascular reserve, carotid plaque echolucency/ulceration/ neovascularization, a lipid-rich necrotic core, a thin or ruptured fibrous cap, silent brain infarction, a contralateral transient ischemic attack/stroke episode, male patients Conclusions Although aggressive risk factor control and BMT should be implemented in all ACS patients, several high-risk features that may increase the risk of a future cerebrovascular event are now documented. Consequently, some guidelines recommend a prophylactic carotid intervention in high-risk patients to prevent future cerebrovascular events. Until the results of the much-anticipated randomized controlled trials emerge, the jury is still out regarding the optimal management of ACS patients.
TL;DR: In this paper , the authors provide leading concepts about the potential mutual benefits of the application of biofabrication technologies in space, and they provide a detailed discussion of the potential benefits of using bio-fabricated tissue and organs in space.
TL;DR: In this paper, the authors draw a parallel between the insights developed within the framework of the current COVID-19 health crisis and the views and insights developed with respect to the long term environmental crisis, the implications for science, technology and innovation (STI) policy, Christopher Freeman analyzed already in the early 90′s.
TL;DR: In this paper, the impact of magnesium intake from any source on bone mineral density (BMD), bone mineral content (BMC), bone turnover markers, and fracture risk in older adults was investigated.
Nagoya City University1, National Cancer Center2, Luxembourg Institute of Health3, University Hospital Waterford4, University of East Anglia5, University of Toronto6, University of Chile7, Maastricht University8, Brigham and Women's Hospital9, University of Calgary10, University of British Columbia11, Katholieke Universiteit Leuven12
TL;DR: In this paper , the authors examined international incidence trends of lung, colorectal, prostate, and breast cancers, as well as all cancers combined excluding non-melanoma skin cancer (NMSC) in adults aged 50 and older, over a fifteen-year period using data from 113 high quality population-based cancer registries included in the Cancer in Five Continents (CI5) series and NORDCAN.
TL;DR: In this paper , the authors present a systematic literature review on efficacy and safety of bDMARDs in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of Spondyloskeletal disorders (ASAS-EULAR) recommendations for the management of axSpA.
Abstract: To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis international Society/European Alliance of Associations for Rheumatology (ASAS-EULAR) recommendations for the management of axSpA.Systematic literature review (2016-2021) on efficacy and safety of bDMARDs in axSpA (radiographic axSpA (r-axSpA)/non-radiographic axSpA (nr-axSpA)). Eligible study designs included randomised controlled trials (RCTs), strategy trials and observational studies (the latter only for safety and extra-musculoskeletal manifestations). All relevant efficacy/safety outcomes were included.In total, 148 publications were included. Efficacy of golimumab and certolizumab was confirmed. Tumour necrosis factor inhibitor (TNFi) biosimilar-originator equivalence was demonstrated. RCT (n=15) data on efficacy of interleukin-17 inhibitors (IL-17i) demonstrated clinically relevant effects (risk ratio vs placebo to achieve ASAS40 response 1.3-15.3 (r-axSpA, n=9), 1.4-2.1 (nr-axSpA, n=2)). Efficacy of secukinumab/ixekizumab was demonstrated in TNFi-naïve and TNFi-inadequate responders. IL-23 and IL-12/23 inhibitors (risankizumab/ustekinumab) failed to show relevant benefits. Tapering of TNFi by spacing was non-inferior to standard-dose treatment. The first axSpA treat-to-target trial did not meet its primary endpoint, but showed improvements in secondary outcomes. No new risks were identified with TNFi use in observational studies (data lacking for IL-17i). Secukinumab (n=1) and etanercept (n=2) were associated with increased risk of uveitis in observational studies compared to monoclonal TNFi.New evidence supports the efficacy and safety of TNFi (originators/biosimilars) and IL-17i in r-axSpA and nr-axSpA, while IL-23i failed to show relevant effects. Observational studies are needed to confirm long-term IL-17i safety.CRD42021257588.
TL;DR: In this paper, various limiting factors in mRNA synthesis, vector formulation, and local delivery to tissues are highlighted together with current developments and the future outlook for mRNA therapeutics in tissue regeneration.
TL;DR: This work investigates the formation and activity of human osteoclasts cultured on biomineralized collagen and pure collagen membranes in comparison to cortical bone slices, and hypothesizes that this composite can undergo cellular resorption and remodeling similar to natural bone.
TL;DR: In this paper, a double pass fundus reflection (DPFR) model is proposed for retinal image enhancement, which reveals the specific double pass reflection feature that was hitherto neglected in modeling the light propagation of fundus imaging in all published reports on retinal enhancement.
TL;DR: A model of attention allocation is proposed that indicates that user attention is most likely to be allocated to applications that have been used both recently and persistently as well as by applications that are popular and current and highlights the negative impact that a large application portfolio has on the allocation of user attention to individual applications.
TL;DR: In this article , the authors investigated the temporal associations between glomerulopathies and vaccination and found that the majority of the cases of primary podocytopathies may develop shortly after vaccination against COVID-19 (i.e., <6 weeks), suggesting a direct role of the vaccine.
TL;DR: In this paper , the authors provided an overview of the limited literature regarding this developing topic for the osteoarthritis field and pointed out that the ribosome as the central cellular protein synthesis hub is largely neglected.
Abstract: Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during osteoarthritis development and progression, the ribosome has received very limited attention as driver of osteoarthritis pathogenesis.We provide an overview of the limited literature regarding this developing topic for the osteoarthritis field. Recent key findings that connect ribosome biogenesis and activity with osteoarthritis include: ribosomal RNA transcription, processing and maturation, ribosomal protein expression, protein translation capacity and preferential translation.The ribosome as the central cellular protein synthesis hub is largely neglected in osteoarthritis research. Findings included in this review reveal that in osteoarthritis, ribosome aberrations have been found from early-stage ribosome biogenesis, through ribosome build-up and maturation, up to preferential translation. Classically, osteoarthritis has been explained as an imbalance between joint tissue anabolism and catabolism. We postulate that osteoarthritis can be interpreted as an acquired ribosomopathy. This hypothesis fine-tunes the dogmatic anabolism/katabolism point-of-view, and may provide novel molecular opportunities for the development of osteoarthritis disease-modifying treatments.
TL;DR: In this paper, the authors found that SlIT1, a secreted protein essential for axonal navigation and molecular guidance during development, is downregulated in the adult ventromedial prefrontal cortex (vmPFC) of women with depression compared with healthy control subjects, but not in men with depression.
TL;DR: In this paper, a lab-in-field experiment was conducted to test the effectiveness of two front-of-package nutrition labels in promoting healthy food choices among Dutch consumers, and to examine whether dieters and health conscious shoppers are more likely to use the FOP labels.
TL;DR: In this paper , a multi-center, nonrandomized controlled trial was performed among women with a histologic diagnosis of cervical intraepithelial neoplasia (CIN), and women were treated with either vaginal imiquimod (6.25 mg 3 times weekly for 8 to 16 wk) or LLETZ according to their own preference.
Abstract: Topical imiquimod could be an alternative, noninvasive, treatment modality for high-grade cervical intraepithelial neoplasia (CIN). However, evidence is limited, and there are no studies that compared treatment effectiveness and side effects of topical imiquimod cream to standard large loop excision of the transformation zone (LLETZ) treatment. A multi-center, nonrandomized controlled trial was performed among women with a histologic diagnosis of CIN 2/3. Women were treated with either vaginal imiquimod (6.25 mg 3 times weekly for 8 to 16 wk) or LLETZ according to their own preference. Successful treatment was defined as the absence of high-grade dysplasia at the first follow-up interval after treatment (at 20 wk for the imiquimod group and at 26 wk for the LLETZ group). Secondary outcome measures were high-risk human papillomavirus (hrHPV) clearance, side effects, and predictive factors for successful imiquimod treatment. Imiquimod treatment was successful in 60% of women who completed imiquimod treatment and 95% of women treated with LLETZ. hrHPV clearance occurred in 69% and 67% in the imiquimod group and LLETZ group, respectively. This study provides further evidence on topical imiquimod cream as a feasible and safe treatment modality for high-grade CIN. Although the effectiveness is considerably lower than LLETZ treatment, imiquimod treatment could prevent initial surgical treatment in over 40% of women and should be offered to a selected population of women who wish to avoid (repeated) surgical treatment of high-grade CIN.