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Maastricht University

EducationMaastricht, Limburg, Netherlands
About: Maastricht University is a education organization based out in Maastricht, Limburg, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 19263 authors who have published 53291 publications receiving 2266866 citations. The organization is also known as: Universiteit Maastricht & UM.


Papers
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Journal ArticleDOI
TL;DR: A new recurrent amplification of MYCL is identified and validated, which is associated with TP53 deletion and unique profiles of DNA damage and transcriptional dysregulation, and this data represents the first systematic relation of intraprostatic genomic heterogeneity to predicted clinical outcome.
Abstract: Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We initially determined the copy number aberration (CNA) profiles of 74 patients with index tumors of Gleason score 7. Of these, 5 patients were subjected to whole-genome sequencing using DNA quantities achievable in diagnostic biopsies, with detailed spatial sampling of 23 distinct tumor regions to assess intraprostatic heterogeneity in focal genomics. Multifocal tumors are highly heterogeneous for single-nucleotide variants (SNVs), CNAs and genomic rearrangements. We identified and validated a new recurrent amplification of MYCL, which is associated with TP53 deletion and unique profiles of DNA damage and transcriptional dysregulation. Moreover, we demonstrate divergent tumor evolution in multifocal cancer and, in some cases, tumors of independent clonal origin. These data represent the first systematic relation of intraprostatic genomic heterogeneity to predicted clinical outcome and inform the development of novel biomarkers that reflect individual prognosis.

413 citations

Journal ArticleDOI
TL;DR: This meta-analysis suggests that bimatoprost, travoprost for glaucoma, latanoprostfor ocular hypertension, and timolol are the most effective intraocular pressure-reducing agents in POAG and OH patients.

413 citations

Journal ArticleDOI
TL;DR: SPECT is widely available and most extensively validated; PET achieved the highest diagnostic performance; CMR may provide an alternative without ionizing radiation and a similar diagnostic accuracy as PET.

412 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present evidence on the differing understandings of the circular economy concept in Chinese and European policy discourse, drawing on qualitative and quantitative analysis of policy documents, media articles, and academic publications.
Abstract: The idea of a circular economy (CE) has become prominent in both European and Chinese policy making. Chinese and European perspectives on a CE share a common conceptual basis and exhibit many similar concerns in seeking to enhance resource efficiency. Yet they also differ, and this article explores differences in the focus of CE policy in China and Europe. We present evidence on the differing understandings of the CE concept in Chinese and European policy discourse, drawing on qualitative and quantitative analysis of policy documents, media articles, and academic publications. We show that the Chinese perspective on the CE is broad, incorporating pollution and other issues alongside waste and resource concerns, and it is framed as a response to the environmental challenges created by rapid growth and industrialization. In contrast, Europe's conception of the CE has a narrower environmental scope, focusing more narrowly on waste and resources and opportunities for business. We then examine similarities and differences in the focus of policy activity in the two regions and in the indicators used to measure progress. We show differences in the treatment of issues of scale and place and different priorities across value chains (from design to manufacture, consumption, and waste management). We suggest some reasons for the divergent policy articulation of the CE concept and suggest lessons that each region can learn from the other.

412 citations

Journal ArticleDOI
01 Nov 2007-Allergy
TL;DR: The microbiota hypothesis in atopic diseases is promising and deserves further attention, but to gain more insight into the role of the gut microbiota in the etiology of atopy, large‐scale prospective birth cohort studies using molecular methods to study the Gut microbiota are needed.
Abstract: The prevalence of atopic diseases, including eczema, allergic rhinoconjunctivitis and asthma, has increased worldwide, predominantly in westernized countries. Recent epidemiological studies and experimental research suggest that microbial stimulation of the immune system influences the development of tolerance to innocuous allergens. The gastrointestinal microbiota composition may be of particular interest, as it provides an early and major source of immune stimulation and seems to be a prerequisite for the development of oral tolerance. In this review the observational studies of the association between the gut microbiota and atopic diseases are discussed. Although most studies indicated an association between the gut microbiota composition and atopic sensitization or symptoms, no specific harmful or protective microbes can be identified yet. Some important methodological issues that have to be considered are the microbiological methods used (traditional culture vs molecular techniques), the timing of examining the gut microbiota, the definition of atopic outcomes, confounding and reverse causation. In conclusion, the microbiota hypothesis in atopic diseases is promising and deserves further attention. To gain more insight into the role of the gut microbiota in the etiology of atopy, large-scale prospective birth cohort studies using molecular methods to study the gut microbiota are needed.

411 citations


Authors

Showing all 19492 results

NameH-indexPapersCitations
Edward Giovannucci2061671179875
Julie E. Buring186950132967
Aaron R. Folsom1811118134044
John J.V. McMurray1781389184502
Alvaro Pascual-Leone16596998251
Lex M. Bouter158767103034
David T. Felson153861133514
Walter Paulus14980986252
Michael Conlon O'Donovan142736118857
Randy L. Buckner141346110354
Philip Scheltens1401175107312
Anne Tjønneland139134591556
Ewout W. Steyerberg139122684896
James G. Herman138410120628
Andrew Steptoe137100373431
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023107
2022344
20214,522
20203,881
20193,367
20183,019