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Institution

Maastricht University

EducationMaastricht, Limburg, Netherlands
About: Maastricht University is a education organization based out in Maastricht, Limburg, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 19263 authors who have published 53291 publications receiving 2266866 citations. The organization is also known as: Universiteit Maastricht & UM.


Papers
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Journal ArticleDOI
TL;DR: In this article, a meta-analysis of problem-based learning in tertiary education is presented, showing that there is a robust positive effect from PBL on the skills of students and no single study reported negative effects.

1,440 citations

Journal ArticleDOI
Ditte Demontis1, Ditte Demontis2, Raymond K. Walters3, Raymond K. Walters4, Joanna Martin5, Joanna Martin6, Joanna Martin3, Manuel Mattheisen, Thomas Damm Als1, Thomas Damm Als2, Esben Agerbo2, Esben Agerbo1, Gisli Baldursson, Rich Belliveau3, Jonas Bybjerg-Grauholm7, Jonas Bybjerg-Grauholm1, Marie Bækvad-Hansen1, Marie Bækvad-Hansen7, Felecia Cerrato3, Kimberly Chambert3, Claire Churchhouse4, Claire Churchhouse3, Ashley Dumont3, Nicholas Eriksson, Michael J. Gandal, Jacqueline I. Goldstein4, Jacqueline I. Goldstein3, Katrina L. Grasby8, Jakob Grove, Olafur O Gudmundsson9, Olafur O Gudmundsson10, Christine Søholm Hansen11, Christine Søholm Hansen7, Christine Søholm Hansen1, Mads E. Hauberg2, Mads E. Hauberg1, Mads V. Hollegaard7, Mads V. Hollegaard1, Daniel P. Howrigan3, Daniel P. Howrigan4, Hailiang Huang4, Hailiang Huang3, Julian Maller3, Alicia R. Martin4, Alicia R. Martin3, Nicholas G. Martin8, Jennifer L. Moran3, Jonatan Pallesen1, Jonatan Pallesen2, Duncan S. Palmer3, Duncan S. Palmer4, Carsten Bøcker Pedersen1, Carsten Bøcker Pedersen2, Marianne Giørtz Pedersen2, Marianne Giørtz Pedersen1, Timothy Poterba4, Timothy Poterba3, Jesper Buchhave Poulsen1, Jesper Buchhave Poulsen7, Stephan Ripke12, Stephan Ripke3, Stephan Ripke4, Elise B. Robinson4, F. Kyle Satterstrom3, F. Kyle Satterstrom4, Hreinn Stefansson10, Christine Stevens3, Patrick Turley4, Patrick Turley3, G. Bragi Walters9, G. Bragi Walters10, Hyejung Won13, Hyejung Won14, Margaret J. Wright15, Ole A. Andreassen16, Philip Asherson17, Christie L. Burton18, Dorret I. Boomsma19, Bru Cormand, Søren Dalsgaard2, Barbara Franke20, Joel Gelernter21, Joel Gelernter22, Daniel H. Geschwind14, Daniel H. Geschwind13, Hakon Hakonarson23, Jan Haavik24, Jan Haavik25, Henry R. Kranzler26, Henry R. Kranzler22, Jonna Kuntsi17, Kate Langley6, Klaus-Peter Lesch27, Klaus-Peter Lesch28, Klaus-Peter Lesch29, Christel M. Middeldorp15, Christel M. Middeldorp19, Andreas Reif30, Luis Augusto Rohde31, Panos Roussos, Russell Schachar18, Pamela Sklar32, Edmund J.S. Sonuga-Barke17, Patrick F. Sullivan5, Patrick F. Sullivan33, Anita Thapar6, Joyce Y. Tung, Irwin D. Waldman34, Sarah E. Medland8, Kari Stefansson10, Kari Stefansson9, Merete Nordentoft1, Merete Nordentoft35, David M. Hougaard7, David M. Hougaard1, Thomas Werge1, Thomas Werge35, Thomas Werge11, Ole Mors1, Ole Mors36, Preben Bo Mortensen, Mark J. Daly, Stephen V. Faraone37, Anders D. Børglum1, Anders D. Børglum2, Benjamin M. Neale4, Benjamin M. Neale3 
TL;DR: A genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls identifies variants surpassing genome- wide significance in 12 independent loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.
Abstract: Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.

1,436 citations

Journal ArticleDOI
TL;DR: In this paper, the authors established reference and normal values for Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, based on a large European population.
Abstract: Aims: Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is to establish reference and normal values for PWV based on a large European population. Methods and results: We gathered data from 16 867 subjects and patients from 13 different centres across eight European countries, in which PWV and basic clinical parameters were measured. Of these, 11 092 individuals were free from overt CV disease, non-diabetic and untreated by either anti-hypertensive or lipid-lowering drugs and constituted the reference value population, of which the subset with optimal/normal blood pressures (BPs) (n = 1455) is the normal value population. Prior to data pooling, PWV values were converted to a common standard using established conversion formulae. Subjects were categorized by age decade and further subdivided according to BP categories. Pulse wave velocity increased with age and BP category; the increase with age being more pronounced for higher BP categories and the increase with BP being more important for older subjects. The distribution of PWV with age and BP category is described and reference values for PWV are established. Normal values are proposed based on the PWV values observed in the non-hypertensive subpopulation who had no additional CV risk factors. Conclusion: The present study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.

1,435 citations

Journal ArticleDOI
TL;DR: The research addressing the relationship of childhood trauma to psychosis and schizophrenia is reviewed, and the theoretical and clinical implications are discussed.
Abstract: Objective: To review the research addressing the relationship of childhood trauma to psychosis and schizophrenia, and to discuss the theoretical and clinical implications. Method: Relevant studies and previous review papers were identified via computer literature searches. Results: Symptoms considered indicative of psychosis and schizophrenia, particularly hallucinations, are at least as strongly related to childhood abuse and neglect as many other mental health problems. Recent large-scale general population studies indicate the relationship is a causal one, with a dose-effect. Conclusion: Several psychological and biological mechanisms by which childhood trauma increases risk for psychosis merit attention. Integration of these different levels of analysis may stimulate a more genuinely integrated bio-psycho-social model of psychosis than currently prevails. Clinical implications include the need for staff training in asking about abuse and the need to offer appropriate psychosocial treatments to patients who have been abused or neglected as children. Prevention issues are also identified.

1,422 citations


Authors

Showing all 19492 results

NameH-indexPapersCitations
Edward Giovannucci2061671179875
Julie E. Buring186950132967
Aaron R. Folsom1811118134044
John J.V. McMurray1781389184502
Alvaro Pascual-Leone16596998251
Lex M. Bouter158767103034
David T. Felson153861133514
Walter Paulus14980986252
Michael Conlon O'Donovan142736118857
Randy L. Buckner141346110354
Philip Scheltens1401175107312
Anne Tjønneland139134591556
Ewout W. Steyerberg139122684896
James G. Herman138410120628
Andrew Steptoe137100373431
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023107
2022344
20214,522
20203,881
20193,367
20183,019