scispace - formally typeset
Search or ask a question
Institution

Maastricht University

EducationMaastricht, Limburg, Netherlands
About: Maastricht University is a education organization based out in Maastricht, Limburg, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 19263 authors who have published 53291 publications receiving 2266866 citations. The organization is also known as: Universiteit Maastricht & UM.


Papers
More filters
Journal ArticleDOI
TL;DR: The authors found little evidence for interaction with other breast cancer risk factors, and data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear.
Abstract: The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (Cl): 0.96, 1.10) in premenopausal women and 1.07 (95% Cl: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% Cl: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% Cl: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women.

975 citations

Journal ArticleDOI
TL;DR: The one-year incidence of multimorbidity was related to increasing age, public health insurance, and the presence of prevalent diseases at baseline, and statistical clustering of diseases was stronger than expected, especially among the younger subjects.

970 citations

Journal ArticleDOI
TL;DR: The overwhelming evidence indicates that ATP and Ado are important endogenous signaling molecules in immunity and inflammation, and it is proposed that their immunological role is both interdependent and multifaceted, meaning that the nature of their effects may shift from immunostimulatory to immunoregulatory or vice versa depending on extracellular concentrations as well as on expression patterns of purinergic receptors and ecto-enzymes.

963 citations

Journal ArticleDOI
TL;DR: In this paper, the authors use a utility model to illustrate that selecting an assessment method involves context-dependent compromises, and that assessment is not a measurement problem but an instructional design problem, comprising educational, implementation and resource aspects.
Abstract: INTRODUCTION We use a utility model to illustrate that, firstly, selecting an assessment method involves context-dependent compromises, and secondly, that assessment is not a measurement problem but an instructional design problem, comprising educational, implementation and resource aspects. In the model, assessment characteristics are differently weighted depending on the purpose and context of the assessment. EMPIRICAL AND THEORETICAL DEVELOPMENTS Of the characteristics in the model, we focus on reliability, validity and educational impact and argue that they are not inherent qualities of any instrument. Reliability depends not on structuring or standardisation but on sampling. Key issues concerning validity are authenticity and integration of competencies. Assessment in medical education addresses complex competencies and thus requires quantitative and qualitative information from different sources as well as professional judgement. Adequate sampling across judges, instruments and contexts can ensure both validity and reliability. Despite recognition that assessment drives learning, this relationship has been little researched, possibly because of its strong context dependence. ASSESSMENT AS INSTRUCTIONAL DESIGN When assessment should stimulate learning and requires adequate sampling, in authentic contexts, of the performance of complex competencies that cannot be broken down into simple parts, we need to make a shift from individual methods to an integral programme, intertwined with the education programme. Therefore, we need an instructional design perspective. IMPLICATIONS FOR DEVELOPMENT AND RESEARCH Programmatic instructional design hinges on a careful description and motivation of choices, whose effectiveness should be measured against the intended outcomes. We should not evaluate individual methods, but provide evidence of the utility of the assessment programme as a whole.

958 citations

Journal ArticleDOI
TL;DR: Most consistent positive correlates of PA were father's PA, time spent outdoors and school PA‐related policies, and support from significant others, mother’s education level, family income, and non‐vocational school attendance (in adolescents).
Abstract: Obesogenic environments are thought to underlie the increased obesity prevalence observed in youth during the past decades. Understanding the environmental factors that are associated with physical activity (PA) in youth is needed to better inform the development of effective intervention strategies attempting to halt the obesity epidemic. We conducted a systematic semi-quantitative review of 150 studies on environmental correlates of youth PA published in the past 25 years. The ANalysis Grid for Environments Linked to Obesity (ANGELO) framework was used to classify the environmental correlates studied. Most studies retrieved used cross-sectional designs and subjective measures of environmental factors and PA. Variables of the home and school environments were especially associated with children's PA. Most consistent positive correlates of PA were father's PA, time spent outdoors and school PA-related policies (in children), and support from significant others, mother's education level, family income, and non-vocational school attendance (in adolescents). Low crime incidence (in adolescents) was characteristic of the neighbourhood environment associated with higher PA. Convincing evidence of an important role for many other environmental factors was, however, not found. Further research should aim at longitudinal and intervention studies, and use more objective measures of PA and its potential (environmental) determinants.

956 citations


Authors

Showing all 19492 results

NameH-indexPapersCitations
Edward Giovannucci2061671179875
Julie E. Buring186950132967
Aaron R. Folsom1811118134044
John J.V. McMurray1781389184502
Alvaro Pascual-Leone16596998251
Lex M. Bouter158767103034
David T. Felson153861133514
Walter Paulus14980986252
Michael Conlon O'Donovan142736118857
Randy L. Buckner141346110354
Philip Scheltens1401175107312
Anne Tjønneland139134591556
Ewout W. Steyerberg139122684896
James G. Herman138410120628
Andrew Steptoe137100373431
Network Information
Related Institutions (5)
University of Pittsburgh
201K papers, 9.6M citations

94% related

University of Amsterdam
140.8K papers, 5.9M citations

93% related

Utrecht University
139.3K papers, 6.2M citations

93% related

Emory University
122.4K papers, 6M citations

93% related

University of Pennsylvania
257.6K papers, 14.1M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023107
2022344
20214,523
20203,881
20193,367
20183,019