Institution
Maastricht University
Education•Maastricht, Limburg, Netherlands•
About: Maastricht University is a education organization based out in Maastricht, Limburg, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 19263 authors who have published 53291 publications receiving 2266866 citations. The organization is also known as: Universiteit Maastricht & UM.
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TL;DR: Comparing the QL of a wide range of chronic disease patients found that patients who were older, female, had a low level of education, were not living with a partner, and had at least one comorbid condition, in general, reported the poorest level of QL.
648 citations
TL;DR: In this article, a simple test for causality in the frequency domain is proposed to investigate the predictive content of the yield spread for future output growth, which can also be applied to cointegrated systems.
647 citations
TL;DR: Supporting evidence was found for only very few presumed environmental determinants of various types and intensities of physical activity among adult men and women and most studies used cross‐sectional designs and non‐validated measures of environments and/or behaviour.
Abstract: The objective of this systematic review of observational studies was to gain insight into potential determinants of various types and intensities of physical activity among adult men and women. Studies were retrieved from Medline, PsycInfo, Embase and Social scisearch. The ANGELO framework was used to classify environmental factors. In total, 47 publications were identified. Social support and having a companion for physical activity were found to be convincingly associated with different types of physical activity [(neighbourhood) walking, bicycling, vigorous physical activity/sports, active commuting, leisure-time physical activity in general, sedentary lifestyle, moderately intense physical activity and a combination of moderately intense and vigorous activity]. Availability of physical activity equipment was convincingly associated with vigorous physical activity/sports and connectivity of trails with active commuting. Other possible, but less consistent correlates of physical activity were availability, accessibility and convenience of recreational facilities. No evidence was found for differences between men and women. In conclusion, supportive evidence was found for only very few presumed environmental determinants. However, most studies used cross-sectional designs and non-validated measures of environments and/or behaviour. Therefore, no strong conclusions can be drawn and more research of better quality is clearly needed.
646 citations
TL;DR: Defining molecular targets on myofibroblasts in conjunction with establishing the feasibility of molecular imaging of these cells might facilitate the early detection and treatment of patients who are at risk of developing heart failure after myocardial infarction.
Abstract: Myofibroblasts have characteristics of fibroblasts and smooth muscle cells: they produce extracellular matrix and are able to contract. In so doing, they can contribute to tissue replacement and interstitial fibrosis following cardiac injury. The scar formed after myocardial injury is no longer considered to be passive tissue; it is an active playground where myofibroblasts play a role in collagen turnover and scar contraction. Maintaining the extracellular matrix in the scar is essential and can prevent dilatation of the infarct area leading to heart failure. On the other hand, extracellular matrix deposition at sites remote from the infarct area can lead to cardiac stiffness, an inevitable process of myocardial remodeling that occurs in the aftermath of myocardial infarction and constitutes the basis of the development of heart failure. Defining molecular targets on myofibroblasts in conjunction with establishing the feasibility of molecular imaging of these cells might facilitate the early detection and treatment of patients who are at risk of developing heart failure after myocardial infarction.
646 citations
TL;DR: A combination of the design and generation of millions to billions of different ligands, together with phage display for the isolation of binding ligands and with functional assays for identifying (and possibly selecting) bio-active ligands will provide a powerful tool for drug and target discovery well into the next decade.
645 citations
Authors
Showing all 19492 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Edward Giovannucci | 206 | 1671 | 179875 |
| Julie E. Buring | 186 | 950 | 132967 |
| Aaron R. Folsom | 181 | 1118 | 134044 |
| John J.V. McMurray | 178 | 1389 | 184502 |
| Alvaro Pascual-Leone | 165 | 969 | 98251 |
| Lex M. Bouter | 158 | 767 | 103034 |
| David T. Felson | 153 | 861 | 133514 |
| Walter Paulus | 149 | 809 | 86252 |
| Michael Conlon O'Donovan | 142 | 736 | 118857 |
| Randy L. Buckner | 141 | 346 | 110354 |
| Philip Scheltens | 140 | 1175 | 107312 |
| Anne Tjønneland | 139 | 1345 | 91556 |
| Ewout W. Steyerberg | 139 | 1226 | 84896 |
| James G. Herman | 138 | 410 | 120628 |
| Andrew Steptoe | 137 | 1003 | 73431 |