Maastricht University

About: Maastricht University is a education organization based out in Maastricht, Limburg, Netherlands. It is known for research contribution in the topics: Population & Health care. The organization has 19263 authors who have published 53291 publications receiving 2266866 citations. The organization is also known as: Universiteit Maastricht & UM.

A Brief Questionnaire for Measuring Self-Efficacy in Youths

Abstract: The current study examined the reliability and validity of the Self-Efficacy Questionnaire for Children (SEQ-C) in a sample of young adolescents (N = 330). Factor analysis of the SEQ-C revealed three factors that were in keeping with the intended subscales: social self-efficacy, academic self-efficacy, and emotional self-efficacy. Furthermore, results showed that the SEQ-C has satisfactory internal consistency. Finally, SEQ-C scores correlated in a theoretically meaningful way with a measure of depression. That is, the lower children's SEQ-C scores, the higher their level of depression. Possible applications of the SEQ-C are briefly discussed.

Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen

Abstract: Platelet adhesion on and activation by components of the extracellular matrix are crucial to arrest post-traumatic bleeding, but can also harm tissue by occluding diseased vessels. Integrin alpha2beta1 is thought to be essential for platelet adhesion to subendothelial collagens, facilitating subsequent interactions with the activating platelet collagen receptor, glycoprotein VI (GPVI). Here we show that Cre/loxP-mediated loss of beta1 integrin on platelets has no significant effect on the bleeding time in mice. Aggregation of beta1-null platelets to native fibrillar collagen is delayed, but not reduced, whereas aggregation to enzymatically digested soluble collagen is abolished. Furthermore, beta1-null platelets adhere to fibrillar, but not soluble collagen under static as well as low (150 s(-1)) and high (1000 s(-1)) shear flow conditions, probably through binding of alphaIIbbeta3 to von Willebrand factor. On the other hand, we show that platelets lacking GPVI can not activate integrins and consequently fail to adhere to and aggregate on fibrillar as well as soluble collagen. These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential.

Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review

Abstract: Background Disability in Activities of Daily Living (ADL) is an adverse outcome of frailty that places a burden on frail elderly people, care providers and the care system. Knowing which physical frailty indicators predict ADL disability is useful in identifying elderly people who might benefit from an intervention that prevents disability or increases functioning in daily life. The objective of this study was to systematically review the literature on the predictive value of physical frailty indicators on ADL disability in community-dwelling elderly people.