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Institution

Macquarie University

EducationSydney, New South Wales, Australia
About: Macquarie University is a education organization based out in Sydney, New South Wales, Australia. It is known for research contribution in the topics: Population & Laser. The organization has 14075 authors who have published 47673 publications receiving 1416184 citations. The organization is also known as: Macquarie uni.
Topics: Population, Laser, Galaxy, Anxiety, Mantle (geology)


Papers
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Journal ArticleDOI
TL;DR: This study demonstrates that the acquisition of reproducible quantitative proteomics data by multiple labs is achievable, and broadly serves to increase confidence in SWATH-mass spectrometry data acquisition as a reproducible method for large-scale protein quantification.
Abstract: Quantitative proteomics employing mass spectrometry is an indispensable tool in life science research. Targeted proteomics has emerged as a powerful approach for reproducible quantification but is limited in the number of proteins quantified. SWATH-mass spectrometry consists of data-independent acquisition and a targeted data analysis strategy that aims to maintain the favorable quantitative characteristics (accuracy, sensitivity, and selectivity) of targeted proteomics at large scale. While previous SWATH-mass spectrometry studies have shown high intra-lab reproducibility, this has not been evaluated between labs. In this multi-laboratory evaluation study including 11 sites worldwide, we demonstrate that using SWATH-mass spectrometry data acquisition we can consistently detect and reproducibly quantify >4000 proteins from HEK293 cells. Using synthetic peptide dilution series, we show that the sensitivity, dynamic range and reproducibility established with SWATH-mass spectrometry are uniformly achieved. This study demonstrates that the acquisition of reproducible quantitative proteomics data by multiple labs is achievable, and broadly serves to increase confidence in SWATH-mass spectrometry data acquisition as a reproducible method for large-scale protein quantification. SWATH-mass spectrometry consists of a data-independent acquisition and a targeted data analysis strategy that aims to maintain the favorable quantitative characteristics on the scale of thousands of proteins. Here, using data generated by eleven groups worldwide, the authors show that SWATH-MS is capable of generating highly reproducible data across different laboratories.

372 citations

Journal ArticleDOI
TL;DR: In this paper, a detailed LAM-ICPMS U-Pb dating and LAMMC-IpMS Lu-Hf isotope analysis were carried out on zircons from nine samples of basement metamorphic rocks in the southern Cathaysia Block, South China.

372 citations

Journal ArticleDOI
TL;DR: This paper’s purpose is to show that imprinting phenomena in endosperm can provide a coherent explanation of some failures of experimental crosses, and of the prevalence of pseudogamy among apomictic angiosperms.
Abstract: If a mother sometimes has offspring by more than one father and if genes in the offspring are active in acquiring resources from maternal tissues, theory predicts that alleles at some loci in the offspring will evolve different patterns of gene expression depending on the gene’s parent of origin (genomic imprinting). The criteria for the evolution of imprinting are satisfied in many seed plants, and imprinting has been reported from the endosperm of angiosperm seeds. This paper’s purpose is to show that imprinting phenomena in endosperm can provide a coherent explanation of some failures of experimental crosses, and of the prevalence of pseudogamy among apomictic angiosperms. As a consequence of imprinting, seed development comes to depend on a particular ratio of maternal and paternal genomes in endosperm. This ratio is normally two maternal genomes to each paternal genome. Imprinting probably accounts for the failure of crosses between diploids and their autotetraploids, because the 2m: 1p ratio is disturbed in such crosses. Imprinting may also account for the breakdown of endosperm in crosses between related species, if the expression of maternal and paternal genomes in endosperm is out of balance. When a cross fails because of such an imbalance, the reciprocal cross will have the opposite imbalance and a complementary phenotype would be expected. The embryological evidence is consistent with this prediction. For example, many incompatible crosses show delayed wall formation in one direction of the cross, but precocious wall formation in the other direction. Typically, seed development can be classified as showing ‘paternal excess’ or ‘maternal excess’. Paternal excess is associated with unusually vigorous early growth of the endosperm, and maternal excess with the opposite. This pattern is consistent with natural selection on paternal gene expression favouring larger seeds. Genetic evidence from maize confirms an association between paternal gene expression and larger kernel size, and maternal gene expression and smaller kernel size. Genomic imprinting creates a requirement for both maternal and paternal genomes in imprinted tissues. In mammals, imprinting is expressed in derivatives of the zygote. The requirement for a paternal genome has constituted a block to the evolution of parthenogenesis, because all the genes in a parthenogenetic embryo are maternal. In angiosperms, imprinting is primarily expressed in the endosperm rather than the embryo. If the effects of imprinting in the embryo are small, an asexually produced embryo can develop, provided that it is associated with a viable endosperm. Many a Pom^ ts are pseudogamous. That is, the endosperm is fertilized and contains maternal and paternal genes embryo is asexual and contains maternal genes only. Thus, the division of labour between the embryo the endosperm during development of the seed can be seen as a preadaptation for apomixis. Some apomicts are autonomous. That is, the embryo and the endosperm both develop without fertilization. Genomic imprinting in endosperm would seem to constitute a barrier to the evolution of autonomous apomixis. Thus, there is a problem, not previously appreciated, in understanding how autonomous apomixis is possible

372 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigate how emerging markets' MNEs may follow quite different patterns to reach, or at least approach, global competitiveness, and investigate how three EM-MNEs pursued global growth through accelerated internationalization combined with strategic and organizational innovation.

371 citations

Journal ArticleDOI
TL;DR: The present study used an articulated thermal manikin with 16 body segments to generate radiative heat transfer coefficients as well as natural- and forced-mode convective coefficients to simulate both transient and spatial inhomogeneities in the thermal environment.
Abstract: Human thermal physiological and comfort models will soon be able to simulate both transient and spatial inhomogeneities in the thermal environment With this increasing detail comes the need for anatomically specific convective and radiative heat transfer coefficients for the human body The present study used an articulated thermal manikin with 16 body segments (head, chest, back, upper arms, forearms, hands, pelvis, upper legs, lower legs, feet) to generate radiative heat transfer coefficients as well as natural- and forced-mode convective coefficients The tests were conducted across a range of wind speeds from still air to 50 m/s, representing atmospheric conditions typical of both indoors and outdoors Both standing and seated postures were investigated, as were eight different wind azimuth angles The radiative heat transfer coefficient measured for the whole-body was 45 W/m2 per K for both the seated and standing cases, closely matching the generally accepted whole-body value of 47 W/m2 per K Similarly, the whole-body natural convection coefficient for the manikin fell within the mid-range of previously published values at 34 and 33 W/m2 per K when standing and seated respectively In the forced convective regime, heat transfer coefficients were higher for hands, feet and peripheral limbs compared to the central torso region Wind direction had little effect on convective heat transfers from individual body segments A general-purpose forced convection equation suitable for application to both seated and standing postures indoors was hc=103v06 for the whole-body Similar equations were generated for individual body segments in both seated and standing postures

369 citations


Authors

Showing all 14346 results

NameH-indexPapersCitations
Yang Yang1712644153049
Peter B. Reich159790110377
Nicholas J. Talley158157190197
John R. Hodges14981282709
Thomas J. Smith1401775113919
Andrew G. Clark140823123333
Joss Bland-Hawthorn136111477593
John F. Thompson132142095894
Xin Wang121150364930
William L. Griffin11786261494
Richard Shine115109656544
Ian T. Paulsen11235469460
Jianjun Liu112104071032
Douglas R. MacFarlane11086454236
Richard A. Bryant10976943971
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023110
2022463
20214,106
20204,009
20193,549
20183,119