Institution
Maharishi Markandeshwar University, Mullana
Education•Ambāla, Haryana, India•
About: Maharishi Markandeshwar University, Mullana is a education organization based out in Ambāla, Haryana, India. It is known for research contribution in the topics: Population & Cloud computing. The organization has 959 authors who have published 1456 publications receiving 16233 citations. The organization is also known as: MMU Mullana & Maharishi Markandeshwar Education Trust.
Topics: Population, Cloud computing, Cancer, Fixed point, Materials science
Papers published on a yearly basis
Papers
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Joan B. Soriano1, Parkes J Kendrick2, Katherine R. Paulson2, Vinay Gupta2 +311 more•Institutions (178)
TL;DR: It is shown that chronic respiratory diseases remain a leading cause of death and disability worldwide, with growth in absolute numbers but sharp declines in several age-standardised estimators since 1990.
829 citations
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Shanghai University1, Peking Union Medical College2, Capital Medical University3, Peking Union Medical College Hospital4, Zhengzhou University5, Qingdao University6, Xi'an Jiaotong University7, Li Ka Shing Faculty of Medicine, University of Hong Kong8, University of Macau9, Russian Academy of Sciences10, University of Valencia11, Maharishi Markandeshwar University, Mullana12, Inha University13, King's College London14, University of Palermo15, University of North Texas Health Science Center16
TL;DR: The intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.
Abstract: A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. This study aims to investigate whether MSC transplantation improves the outcome of 7 enrolled patients with COVID-19 pneumonia in Beijing YouAn Hospital, China, from Jan 23, 2020 to Feb 16, 2020. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. MSCs could cure or significantly improve the functional outcomes of seven patients without observed adverse effects. The pulmonary function and symptoms of these seven patients were significantly improved in 2 days after MSC transplantation. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. In addition, a group of CD14+CD11c+CD11bmid regulatory DC cell population dramatically increased. Meanwhile, the level of TNF-α was significantly decreased, while IL-10 increased in MSC treatment group compared to the placebo control group. Furthermore, the gene expression profile showed MSCs were ACE2- and TMPRSS2- which indicated MSCs are free from COVID-19 infection. Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.
765 citations
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TL;DR: This paper introduces an energy efficient heterogeneous clustered scheme for wireless sensor networks based on weighted election probabilities of each node to become a cluster head according to the residual energy in each node.
727 citations
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13 Nov 2019
TL;DR: The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously.
Abstract: Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration mediated effects. Interestingly, ROS also dynamically influences the tumor microenvironment and is known to initiate cancer angiogenesis, metastasis, and survival at different concentrations. At moderate concentration, ROS activates the cancer cell survival signaling cascade involving mitogen-activated protein kinase/extracellular signal-regulated protein kinases 1/2 (MAPK/ERK1/2), p38, c-Jun N-terminal kinase (JNK), and phosphoinositide-3-kinase/ protein kinase B (PI3K/Akt), which in turn activate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF). At high concentrations, ROS can cause cancer cell apoptosis. Hence, it critically depends upon the ROS levels, to either augment tumorigenesis or lead to apoptosis. The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously. Overall, additional research is required to comprehend the potential of ROS as an effective anti-tumor modality and therapeutic target for treating malignancies.
539 citations
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TL;DR: In this paper, a review on the phenomenon of surface modification by electric discharge machining and future trends of its applications is presented, with particular emphasis on the potential of this process for surface modification.
432 citations
Authors
Showing all 999 results
Name | H-index | Papers | Citations |
---|---|---|---|
Vinod Kumar | 77 | 815 | 26882 |
Manish Kumar | 61 | 1425 | 21762 |
Arun Sharma | 55 | 371 | 11364 |
Rashmi Gupta | 52 | 428 | 50962 |
Amit Agrawal | 47 | 882 | 10465 |
Swaranjit Singh Cameotra | 44 | 128 | 8287 |
Marin Marin | 41 | 193 | 3419 |
Nitin Gupta | 35 | 604 | 5267 |
Ashish Garg | 34 | 246 | 4172 |
Pradeep Sharma | 33 | 436 | 4825 |
Anil K. Sharma | 32 | 252 | 4392 |
Mohammad Hifz Ur Rahman | 28 | 47 | 39900 |
Joginder Singh | 28 | 234 | 2758 |
Navpreet Kaur | 27 | 183 | 2901 |
Krishna Murari Pandey | 27 | 262 | 2455 |