Showing papers by "Mahidol University published in 1969"
TL;DR: The data suggest that lactase in mammals may be an adaptive enzyme and Tile failure of the postsuckling decline to occur in man would be consistent with this hypothesis because of the continued inclusion of milk and milk products in the duet after infancy.
82 citations
TL;DR: It is realized that Hb H (β4) is connected with α-thalassaemia5 which, by suppressing α-chain synthesis, leads to polymerization of the unconjugated β-chains to a tetrameric form, which occurs in Hb γ4 (Bart's) and Hbδ4 occur as a result of α- chain suppression6,7.
Abstract: HAEMOGLOBIN H disease is usually a mild to moderate, sometimes severe, thalassaemic disease, characterized by the presence of haemoglobin (Hb) H in addition to Hb A, and intraerythrocytic inclusion bodies1–3. Hb H is usually not detectable in either parent of the patients. The genetic basis of the disease was a subject for speculation until Hb H was shown to consist entirely of β-polypeptide chains4, with a molecular formula of β4, while Hb A is α2β2. It is now realized that Hb H (β4) is connected with α-thalassaemia5 which, by suppressing α-chain synthesis, leads to polymerization of the unconjugated β-chains to a tetrameric form. For the same reason Hb γ4 (Bart's) and Hb δ4 occur as a result of α-chain suppression6,7. Both haemoglobins can be detected in the people with Hb H disease.
29 citations
TL;DR: Drosophila birchii, a member of the melanogaster species group of the subgenus Sophophora, is common in the tropical rain forests of the Australia-New Guinea areas and exhibits a remarkable karyotype variation.
Abstract: Drosophila birchii, a member of the melanogaster species group of the subgenus Sophophora, is common in the tropical rain forests of the Australia-New Guinea areas. Chromosome squashes are easily prepared from the larval ganglion cells and the sex chromosomes are readily recognizable. The species exhibits a remarkable karyotype variation. The metaphase plate figures, in general, show two pairs of V's, one pair of dots and one pair of sex chromosomes. Variations in metaphase chromosome morphology are found in the X (with four types), the Y (with three types) and chromosome IV (with two types). Chromosomal interchanges between X- and Y-chromosomes Type I are postulated to be involved in the differentiation of sex chromosome morphology while the modification of chromosome IV seems likely to be a result of the acquisition of extra heterochromatin. These chromosome types form seven distinct metaphase plate figures, all encountered in wild populations, thus giving D. birchii the most variable karyotype in the genus Drosophila.
20 citations
11 citations
TL;DR: No consistent differences in the reactions of the tumor tissues were observed in relation to the presence or absence of cirrhosis, and enzymatic activities of carcinomas of the liver were not related with the morphological grade of differentiation.
Abstract: A histochemical study of a number of hydrolytic and oxidative enzymes was made on 29 surgical biopsy and 15 postmortem specimens of primary hepatic carcinoma. Alkaline phosphatase could not be demonstrated in tumor tissue from any of the 44 cases studied. Lactate and isocitric dehydrogenases, and DPNH-diaphorase showed greater intensities of reaction in a majority of the tumors as compared with nontumorous parenchyma on the same slides. Enzyme reactions appeared to be greater in the liver tissue than in the tumor nodules in a majority of cases for glucose-6-phosphate, glutamate, beta-hydroxybutyric, and 6-phosphogluconate dehydrogenases. This difference was most prominent in the last 2 enzymes. Dihydro-orotate dehydrogenase and TPNH-diaphorase gave variable results. Similar results were obtained in both surgical biopsy and postmortem specimens. No consistent differences in the reactions of the tumor tissues were observed in relation to the presence or absence of cirrhosis. Enzymatic activities of carcinomas of the liver were not related with the morphological grade of differentiation.
3 citations