Institution
Mahidol University
Education•Bangkok, Nakhon Pathom, Thailand•
About: Mahidol University is a education organization based out in Bangkok, Nakhon Pathom, Thailand. It is known for research contribution in the topics: Population & Malaria. The organization has 23758 authors who have published 39761 publications receiving 878781 citations.
Papers published on a yearly basis
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McGill University1, Cliniques Universitaires Saint-Luc2, King Saud University3, University of New South Wales4, University College London5, Institute of Chartered Accountants of Nigeria6, University of Pisa7, University of Padua8, Columbia University9, Cornell University10, Peking University11, University of Tokyo12, Osaka University13, Complutense University of Madrid14, University of Concepción15, Kumamoto University16, Brigham and Women's Hospital17, Cardiovascular Institute of the South18, Jaslok Hospital19, Mahidol University20, University of the Philippines21, Hacettepe University22, University of Illinois at Chicago23, Nord University24, University of Würzburg25, Fudan University26, Baker IDI Heart and Diabetes Institute27
TL;DR: Monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk, and several emerging treatments may offer promise.
Abstract: Cardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, can ameliorate the risk of vascular complications, patients remain at high risk of cardiovascular events. The Residual Risk Reduction Initiative (R3i) has previously highlighted atherogenic dyslipidaemia, defined as the imbalance between proatherogenic triglyceride-rich apolipoprotein B-containing-lipoproteins and antiatherogenic apolipoprotein A-I-lipoproteins (as in high-density lipoprotein, HDL), as an important modifiable contributor to lipid-related residual cardiovascular risk, especially in insulin-resistant conditions. As part of its mission to improve awareness and clinical management of atherogenic dyslipidaemia, the R3i has identified three key priorities for action: i) to improve recognition of atherogenic dyslipidaemia in patients at high cardiometabolic risk with or without diabetes; ii) to improve implementation and adherence to guideline-based therapies; and iii) to improve therapeutic strategies for managing atherogenic dyslipidaemia. The R3i believes that monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk. Addition of a fibrate, niacin (North and South America), omega-3 fatty acids or ezetimibe are all options for combination with a statin to further reduce non-HDL cholesterol, although lacking in hard evidence for cardiovascular outcome benefits. Several emerging treatments may offer promise. These include the next generation peroxisome proliferator-activated receptorα agonists, cholesteryl ester transfer protein inhibitors and monoclonal antibody therapy targeting proprotein convertase subtilisin/kexin type 9. However, long-term outcomes and safety data are clearly needed. In conclusion, the R3i believes that ongoing trials with these novel treatments may help to define the optimal management of atherogenic dyslipidaemia to reduce the clinical and socioeconomic burden of residual cardiovascular risk.
153 citations
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TL;DR: In this article, the influence of concentration of microfibrillated cellulose (MFC) extracted from mangosteen ( Garcinia mangostana L.) rind on the properties and stability of 10% w/w soybean oil-in-water (o/w) Pickering emulsions (pH ≤ 7.0) was examined.
153 citations
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University of Brescia1, University Hospitals Birmingham NHS Foundation Trust2, Mansoura University3, Ahmadu Bello University4, Başkent University5, Mustafa Kemal University6, Sakarya University7, Medical University Plovdiv8, Hadassah Medical Center9, UCLA Medical Center10, Sapienza University of Rome11, University of California, San Diego12, Central University, India13, Qatar Airways14, State University of Campinas15, National and Kapodistrian University of Athens16, Karadeniz Technical University17, Government Medical College, Thiruvananthapuram18, Aristotle University of Thessaloniki19, Erzincan University20, Hospital of Lithuanian University of Health Sciences Kaunas Clinics21, University of Belgrade22, Turku University Hospital23, Jubilee Mission Medical College and Research Institute24, Jagiellonian University Medical College25, LAC+USC Medical Center26, Inje University27, Edendale Hospital28, Mahidol University29, University Hospital Centre Zagreb30, University of the West Indies31, AHEPA University Hospital32, University of Ilorin33, King Abdullah University Hospital34, University of Valle35, SIDI36, King George's Medical University37, Bharati Vidyapeeth University38, Russells Hall Hospital39, Tan Tock Seng Hospital40, Russian Railways41, Jagiellonian University42, Tbilisi State Medical University43, University of Pécs44, Kocaeli University45, Memorial Hospital of South Bend46, Nankai University47
TL;DR: The results of the present study confirm the clinical value of imaging techniques and prognostic scores and confirm that appendectomy remains the most effective treatment of acute appendicitis.
Abstract: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments. This prospective multicenter observational study was performed in 116 worldwide surgical departments from 44 countries over a 6-month period (April 1, 2016–September 30, 2016). All consecutive patients admitted to surgical departments with a clinical diagnosis of AA were included in the study. A total of 4282 patients were enrolled in the POSAW study, 1928 (45%) women and 2354 (55%) men, with a median age of 29 years. Nine hundred and seven (21.2%) patients underwent an abdominal CT scan, 1856 (43.3%) patients an US, and 285 (6.7%) patients both CT scan and US. A total of 4097 (95.7%) patients underwent surgery; 1809 (42.2%) underwent open appendectomy and 2215 (51.7%) had laparoscopic appendectomy. One hundred eighty-five (4.3%) patients were managed conservatively. Major complications occurred in 199 patients (4.6%). The overall mortality rate was 0.28%. The results of the present study confirm the clinical value of imaging techniques and prognostic scores. Appendectomy remains the most effective treatment of acute appendicitis. Mortality rate is low.
153 citations
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TL;DR: These findings are the first evidence that RNAi-mediated gene silencing is operative in shrimp cells, and could be a powerful tool for studying gene function and to develop effective control of viral infection in shrimp.
152 citations
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152 citations
Authors
Showing all 23819 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas J. White | 161 | 1352 | 104539 |
Pete Smith | 156 | 2464 | 138819 |
Randal J. Kaufman | 140 | 491 | 79527 |
Kevin Marsh | 128 | 567 | 55356 |
Barry M. Trost | 124 | 1635 | 79501 |
John R. Perfect | 119 | 573 | 52325 |
Jon Clardy | 116 | 983 | 56617 |
François Nosten | 114 | 777 | 50823 |
Paul Turner | 114 | 1099 | 61390 |
Paul Kubes | 109 | 393 | 41022 |
Ian M. Adcock | 107 | 660 | 42380 |
Peter H. Verburg | 107 | 464 | 34254 |
Guozhong Cao | 104 | 694 | 41625 |
Carol L. Shields | 102 | 1424 | 46800 |
Nicholas P. J. Day | 102 | 708 | 50588 |