scispace - formally typeset
Search or ask a question
Institution

Mahidol University

EducationBangkok, Nakhon Pathom, Thailand
About: Mahidol University is a education organization based out in Bangkok, Nakhon Pathom, Thailand. It is known for research contribution in the topics: Population & Malaria. The organization has 23758 authors who have published 39761 publications receiving 878781 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk, and several emerging treatments may offer promise.
Abstract: Cardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, can ameliorate the risk of vascular complications, patients remain at high risk of cardiovascular events. The Residual Risk Reduction Initiative (R3i) has previously highlighted atherogenic dyslipidaemia, defined as the imbalance between proatherogenic triglyceride-rich apolipoprotein B-containing-lipoproteins and antiatherogenic apolipoprotein A-I-lipoproteins (as in high-density lipoprotein, HDL), as an important modifiable contributor to lipid-related residual cardiovascular risk, especially in insulin-resistant conditions. As part of its mission to improve awareness and clinical management of atherogenic dyslipidaemia, the R3i has identified three key priorities for action: i) to improve recognition of atherogenic dyslipidaemia in patients at high cardiometabolic risk with or without diabetes; ii) to improve implementation and adherence to guideline-based therapies; and iii) to improve therapeutic strategies for managing atherogenic dyslipidaemia. The R3i believes that monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk. Addition of a fibrate, niacin (North and South America), omega-3 fatty acids or ezetimibe are all options for combination with a statin to further reduce non-HDL cholesterol, although lacking in hard evidence for cardiovascular outcome benefits. Several emerging treatments may offer promise. These include the next generation peroxisome proliferator-activated receptorα agonists, cholesteryl ester transfer protein inhibitors and monoclonal antibody therapy targeting proprotein convertase subtilisin/kexin type 9. However, long-term outcomes and safety data are clearly needed. In conclusion, the R3i believes that ongoing trials with these novel treatments may help to define the optimal management of atherogenic dyslipidaemia to reduce the clinical and socioeconomic burden of residual cardiovascular risk.

153 citations

Journal ArticleDOI
TL;DR: In this article, the influence of concentration of microfibrillated cellulose (MFC) extracted from mangosteen ( Garcinia mangostana L.) rind on the properties and stability of 10% w/w soybean oil-in-water (o/w) Pickering emulsions (pH ≤ 7.0) was examined.

153 citations

Journal ArticleDOI
Massimo Sartelli, Gian L. Baiocchi1, Salomone Di Saverio, Francesco Ferrara, Francesco M. Labricciosa, Luca Ansaloni, Federico Coccolini, Deepak Vijayan2, Ashraf Abbas3, Hariscine K. Abongwa, John Agboola, Adamu Ahmed4, Lali Akhmeteli, Nezih Akkapulu5, Seckin Akkucuk6, Fatih Altintoprak7, Aurelia L. Andreiev2, Dimitrios Anyfantakis, Boiko Atanasov8, Miklosh Bala9, Dimitrios Balalis, Oussama Baraket, Giovanni Bellanova, Marcelo A. Beltrán, Renato Bessa Melo, Roberto Bini, Konstantinos Bouliaris, Daniele Brunelli, Adrian Castillo10, Marco Catani11, Asri Che Jusoh, Alain Chichom-Mefire, Gianfranco Cocorullo, Raul Coimbra12, Elif Colak, Silvia Figueiredo Costa, Koray Das, Samir Delibegovic, Zaza Demetrashvili13, Isidoro Di Carlo14, Nadezda Kiseleva, Tamer El Zalabany, Mario Paulo Faro, Margarida Ferreira, Gustavo Pereira Fraga15, Mahir Gachabayov, Wagih Ghnnam3, Teresa Giménez Maurel, Georgios Gkiokas16, Carlos Augusto Gomes, Ewen A. Griffiths2, Ali Guner17, Sanjay Gupta18, Andreas Hecker, Elcio S. Hirano15, Adrien Hodonou, Martin Hutan, Orestis Ioannidis19, Arda Isik20, G B Ivakhov, Sumita A Jain, Mantas Jokubauskas21, Aleksandar Karamarkovic22, Saila Kauhanen23, Robin Kaushik18, Alfie J. Kavalakat24, Jakub Kenig25, Vladimir Khokha, Desmond Khor26, Dennis Y. Kim10, Jae I. Kim27, Victor Y. Kong28, Konstantinos Lasithiotakis, Pedro Leão, Miguel Leon, Andrey Litvin, Varut Lohsiriwat29, Eudaldo López-Tomassetti Fernandez, Eftychios Lostoridis, James D. Maciel10, Piotr Major25, Ana Dimova30, Dimitrios K. Manatakis, Athanasio Marinis, Aleix Martínez-Pérez, Sanjay Marwah, Michael McFarlane31, Cristian Mesina, Michał Pędziwiatr, N. Michalopoulos32, Evangelos P. Misiakos16, Ali Yasen Y. Mohamedahmed, Radu Moldovanu, Giulia Montori, Raghuveer Mysore Narayana, Ionut Negoi, Ioannis Nikolopoulos, Giuseppe Novelli, Viktors Novikovs, Iyiade Olaoye33, Abdelkarim H. Omari34, Carlos A. Ordoñez35, Mouaqit Ouadii36, Zeynep Özkan, Ajay Kumar Pal37, Gian Marco Palini, Lars Ivo Partecke, Francesco Pata, Gerson Alves Pereira Júnior, Tadeja Pintar, Magdalena Pisarska, Cesar F. Ploneda-Valencia, Konstantinos Pouggouras, Vinod V. Prabhu38, Padmakumar Ramakrishnapillai, Jean-Marc Regimbeau, Marianne Marchini Reitz, Daniel Rios-Cruz, Sten Saar, Boris Sakakushev, Charalampos Seretis39, Alexander Sazhin, Vishal G Shelat40, Matej Skrovina, Dmitry Smirnov41, Charalampos Spyropoulos, Marcin Strzałka42, Peep Talving, Ricardo Alessandro Teixeira Gonsaga, George Theobald2, G. Tomadze43, Myftar Torba, Cristian Tranà, Jan Ulrych, Mustafa Yener Uzunoglu6, Alin Vasilescu, Savino Occhionorelli, Aurélien Venara, András Vereczkei44, Nereo Vettoretto, Nutu Vlad, Maciej Walędziak, Tonguç Utku Yılmaz45, Kuo-Ching Yuan46, Cui Yun-feng47, Justas Zilinskas21, Gérard Grelpois, Fausto Catena3 
TL;DR: The results of the present study confirm the clinical value of imaging techniques and prognostic scores and confirm that appendectomy remains the most effective treatment of acute appendicitis.
Abstract: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments. This prospective multicenter observational study was performed in 116 worldwide surgical departments from 44 countries over a 6-month period (April 1, 2016–September 30, 2016). All consecutive patients admitted to surgical departments with a clinical diagnosis of AA were included in the study. A total of 4282 patients were enrolled in the POSAW study, 1928 (45%) women and 2354 (55%) men, with a median age of 29 years. Nine hundred and seven (21.2%) patients underwent an abdominal CT scan, 1856 (43.3%) patients an US, and 285 (6.7%) patients both CT scan and US. A total of 4097 (95.7%) patients underwent surgery; 1809 (42.2%) underwent open appendectomy and 2215 (51.7%) had laparoscopic appendectomy. One hundred eighty-five (4.3%) patients were managed conservatively. Major complications occurred in 199 patients (4.6%). The overall mortality rate was 0.28%. The results of the present study confirm the clinical value of imaging techniques and prognostic scores. Appendectomy remains the most effective treatment of acute appendicitis. Mortality rate is low.

153 citations

Journal ArticleDOI
TL;DR: These findings are the first evidence that RNAi-mediated gene silencing is operative in shrimp cells, and could be a powerful tool for studying gene function and to develop effective control of viral infection in shrimp.

152 citations

Journal ArticleDOI
EE Calle1, CW Heath1, H. L. Miracle-McMahill1, R. J. Coates2  +183 moreInstitutions (39)

152 citations


Authors

Showing all 23819 results

NameH-indexPapersCitations
Nicholas J. White1611352104539
Pete Smith1562464138819
Randal J. Kaufman14049179527
Kevin Marsh12856755356
Barry M. Trost124163579501
John R. Perfect11957352325
Jon Clardy11698356617
François Nosten11477750823
Paul Turner114109961390
Paul Kubes10939341022
Ian M. Adcock10766042380
Peter H. Verburg10746434254
Guozhong Cao10469441625
Carol L. Shields102142446800
Nicholas P. J. Day10270850588
Network Information
Related Institutions (5)
University of Hong Kong
99.1K papers, 3.2M citations

86% related

University of Maryland, Baltimore
64.7K papers, 2.9M citations

86% related

University of Alabama at Birmingham
86.7K papers, 3.9M citations

86% related

Case Western Reserve University
106.5K papers, 5M citations

86% related

University of Pittsburgh
201K papers, 9.6M citations

85% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202329
2022187
20213,386
20203,028
20192,630
20182,531