Institution
Mahidol University
Education•Bangkok, Nakhon Pathom, Thailand•
About: Mahidol University is a education organization based out in Bangkok, Nakhon Pathom, Thailand. It is known for research contribution in the topics: Population & Malaria. The organization has 23758 authors who have published 39761 publications receiving 878781 citations.
Topics: Population, Malaria, Plasmodium falciparum, Medicine, Plasmodium vivax
Papers published on a yearly basis
Papers
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TL;DR: In this paper, structural analysis of the ACE2 binding sites of the SARS-CoV-2 pandemic strain has been carried out and the authors show that the 222 light chain is able to largely restore neutralization potency to a major class of public antibodies.
439 citations
TL;DR: The study showed that gill lamellae and kidney tubules were the primary target organs for the acute toxic effect of cadmium while in the subchronic exposure, the toxic effect to gills was less than that of kidney and liver.
439 citations
Medical Research Council1, Wellcome Trust Centre for Human Genetics2, Wellcome Trust Sanger Institute3, National Institutes of Health4, University for Development Studies5, University of Oxford6, Mahidol University7, University of Maryland, Baltimore8, World Health Organization9, Pasteur Institute10, University of London11, Charles Darwin University12
TL;DR: An analysis of genome variation in 825 P. falciparum samples from Asia and Africa is described that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia, and a catalog of SNPs that show high levels of differentiation in the art Artemisinin-resistant subpopulations are provided.
Abstract: We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination.
438 citations
TL;DR: Quantification of CSF cultures provides a powerful new means to accurately assess the fungicidal activity of new treatment regimens for cryptococcal meningitis.
433 citations
TL;DR: Total production of cultivated penaeid shrimp from Asia will probably continue to rise as transient disease problems are solved and use of post larvae originating from domesticated SPF shrimp stocks in more biosecure settings expands.
433 citations
Authors
Showing all 23819 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nicholas J. White | 161 | 1352 | 104539 |
| Pete Smith | 156 | 2464 | 138819 |
| Randal J. Kaufman | 140 | 491 | 79527 |
| Kevin Marsh | 128 | 567 | 55356 |
| Barry M. Trost | 124 | 1635 | 79501 |
| John R. Perfect | 119 | 573 | 52325 |
| Jon Clardy | 116 | 983 | 56617 |
| François Nosten | 114 | 777 | 50823 |
| Paul Turner | 114 | 1099 | 61390 |
| Paul Kubes | 109 | 393 | 41022 |
| Ian M. Adcock | 107 | 660 | 42380 |
| Peter H. Verburg | 107 | 464 | 34254 |
| Guozhong Cao | 104 | 694 | 41625 |
| Carol L. Shields | 102 | 1424 | 46800 |
| Nicholas P. J. Day | 102 | 708 | 50588 |