Institution
Makerere University
Education•Kampala, Uganda•
About: Makerere University is a education organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 7220 authors who have published 12405 publications receiving 366520 citations. The organization is also known as: Makerere University Kampala & MUK.
Papers published on a yearly basis
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University of Toronto1, National Health and Medical Research Council2, Medicines and Healthcare Products Regulatory Agency3, Johns Hopkins University4, King's College London5, University of Paris6, University of Western Ontario7, University of Sydney8, Technical University of Berlin9, University of Nottingham10, National Institute for Health Research11, University of Ottawa12, Food and Drug Administration13, Tufts University14, University of Oxford15, Sichuan University16, FHI 36017, University of North Carolina at Chapel Hill18, Yale University19, American Medical Association20, Canadian Institutes of Health Research21, University of Texas at San Antonio22, South African Medical Research Council23, Lawrence Berkeley National Laboratory24, National Institutes of Health25, Makerere University26, University of Southern Denmark27
TL;DR: The CONSERVE (ConSORT and SpiritIT Extension for RCTs Revised in Extenuating Circumstances) guideline as mentioned in this paper aims to improve reporting of trial protocols and completed trials that undergo important modifications in response to extenuating circumstances.
Abstract: Importance Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, and analytical challenges that can potentially compromise the validity of findings. Numerous randomized trials have required changes in response to the COVID-19 pandemic, but guidance for reporting such modifications is incomplete. Objective As a joint extension for the CONSORT and SPIRIT reporting guidelines, CONSERVE (CONSORT and SPIRIT Extension for RCTs Revised in Extenuating Circumstances) aims to improve reporting of trial protocols and completed trials that undergo important modifications in response to extenuating circumstances. Evidence A panel of 37 international trial investigators, patient representatives, methodologists and statisticians, ethicists, funders, regulators, and journal editors convened to develop the guideline. The panel developed CONSERVE following an accelerated, iterative process between June 2020 and February 2021 involving (1) a rapid literature review of multiple databases (OVID Medline, OVID EMBASE, and EBSCO CINAHL) and gray literature sources from 2003 to March 2021; (2) consensus-based panelist meetings using a modified Delphi process and surveys; and (3) a global survey of trial stakeholders. Findings The rapid review yielded 41 673 citations, of which 38 titles were relevant, including emerging guidance from regulatory and funding agencies for managing the effects of the COVID-19 pandemic on trials. However, no generalizable guidance for all circumstances in which trials and trial protocols might face unanticipated modifications were identified. The CONSERVE panel used these findings to develop a consensus reporting guidelines following 4 rounds of meetings and surveys. Responses were received from 198 professionals from 34 countries, of whom 90% (n = 178) indicated that they understood the concept definitions and 85.4% (n = 169) indicated that they understood and could use the implementation tool. Feedback from survey respondents was used to finalize the guideline and confirm that the guideline’s core concepts were applicable and had utility for the trial community. CONSERVE incorporates an implementation tool and checklists tailored to trial reports and trial protocols for which extenuating circumstances have resulted in important modifications to the intended study procedures. The checklists include 4 sections capturing extenuating circumstances, important modifications, responsible parties, and interim data analyses. Conclusions and Relevance CONSERVE offers an extension to CONSORT and SPIRIT that could improve the transparency, quality, and completeness of reporting important modifications to trials in extenuating circumstances such as COVID-19.
123 citations
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TL;DR: The 17-day SSG & PM combination treatment had a good safety profile and was similar in efficacy to the standard 30 day SSG treatment, suggesting suitability for VL treatment in East Africa.
Abstract: Background: Alternative treatments for visceral leishmaniasis (VL) are required in East Africa. Paromomycin sulphate (PM) has been shown to be efficacious for VL treatment in India. Methods: A multi-centre randomized-controlled trial (RCT) to compare efficacy and safety of PM (20 mg/kg/day for 21 days) and PM plus sodium stibogluconate (SSG) combination (PM, 15 mg/kg/day and SSG, 20 mg/kg/day for 17 days) with SSG (20 mg/kg/day for 30 days) for treatment of VL in East Africa. Patients aged 4–60 years with parasitologically confirmed VL were enrolled, excluding patients with contraindications. Primary and secondary efficacy outcomes were parasite clearance at 6-months follow-up and end of treatment, respectively. Safety was assessed mainly using adverse event (AE) data. Findings: The PM versus SSG comparison enrolled 205 patients per arm with primary efficacy data available for 198 and 200 patients respectively. The SSG & PM versus SSG comparison enrolled 381 and 386 patients per arm respectively, with primary efficacy data available for 359 patients per arm. In Intention-to-Treat complete-case analyses, the efficacy of PM was significantly lower than SSG (84.3% versus 94.1%, difference=9.7%, 95% confidence interval, CI: 3.6 to 15.7%, p=0.002). The efficacy of SSG & PM was comparable to SSG (91.4% versus 93.9%, difference=2.5%, 95% CI: 21.3 to 6.3%, p=0.198). End of treatment efficacy results were very similar. There were no apparent differences in the safety profile of the three treatment regimens. Conclusion: The 17 day SSG & PM combination treatment had a good safety profile and was similar in efficacy to the standard 30 day SSG treatment, suggesting suitability for VL treatment in East Africa.
123 citations
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Lea Berrang-Ford1, A. R. Siders2, Alexandra Lesnikowski3, Alexandra Paige Fischer4 +147 more•Institutions (87)
TL;DR: In this article, the authors present a systematic and comprehensive global stocktake of implemented human adaptation to climate change and identify eight priorities for global adaptation research: assess the effectiveness of adaptation responses, enhance the understanding of limits to adaptation, enable individuals and civil society to adapt, include missing places, scholars and scholarship, understand private sector responses, improve methods for synthesizing different forms of evidence, assess the adaptation at different temperature thresholds, and improve the inclusion of timescale and the dynamics of responses.
Abstract: Assessing global progress on human adaptation to climate change is an urgent priority. Although the literature on adaptation to climate change is rapidly expanding, little is known about the actual extent of implementation. We systematically screened >48,000 articles using machine learning methods and a global network of 126 researchers. Our synthesis of the resulting 1,682 articles presents a systematic and comprehensive global stocktake of implemented human adaptation to climate change. Documented adaptations were largely fragmented, local and incremental, with limited evidence of transformational adaptation and negligible evidence of risk reduction outcomes. We identify eight priorities for global adaptation research: assess the effectiveness of adaptation responses, enhance the understanding of limits to adaptation, enable individuals and civil society to adapt, include missing places, scholars and scholarship, understand private sector responses, improve methods for synthesizing different forms of evidence, assess the adaptation at different temperature thresholds, and improve the inclusion of timescale and the dynamics of responses. Determining progress in adaptation to climate change is challenging, yet critical as climate change impacts increase. A stocktake of the scientific literature on implemented adaptation now shows that adaptation is mostly fragmented and incremental, with evidence lacking for its impact on reducing risk.
123 citations
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TL;DR: Pregnant adolescents lack basic needs like shelter, food and security and face relational problems with families, partners and the community, and there is a need to sensitize the community and school personnel about adolescent reproductive health issues.
Abstract: Background: In Uganda, morbidity and mortality among adolescent mothers and their children are high. Social factors behind this problem need to be better understood.
Objective: To explore problems that pregnant adolescents face in order to design appropriate policies and interventions.
Methods: This was a descriptive study that utilized qualitative methods for data collection. The study population comprised of pregnant adolescents, adolescent mothers, opinion leaders, In-charge of health unit, and Traditional Birth Attendants (TBAs) in Wakiso district, Uganda. Six Focus Group Discussions (FGDs) with adolescent mothers and pregnant adolescents, and six key informant interviews were conducted with leaders in-charge of health units and TBAs. A moderator and a note taker facilitated the FGDs, which were tape recorded with consent from participants. Qualitative content analysis was done.
Results: Discussions revealed that pregnant adolescents faced domestic physical violence. Furthermore, they were psychologically violated by parents and partners, and the community within which they lived. Pregnant adolescents were treated inhumanely and overworked with household chores and had inadequate food to eat. Adolescents experienced stigma and as a result some had carried out unsafe abortions. Key informant interviews and FGDs revealed that health workers were rude and unsympathetic to pregnant adolescents. This significantly contributed to delayed health care seeking when adolescents were ill.
Conclusion: Pregnant adolescents lack basic needs like shelter, food and security. They also face relational problems with families, partners and the community. There is, therefore, a need to sensitize the community and school personnel about adolescent reproductive health issues. In addition, adolescent friendly services need to be established/strengthened. Continuous in-service training for health workers with emphasis on counseling skills for young people is urgently needed. African Health Sciences Vol. 5 (4) 2005: pp. 304-309
123 citations
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TL;DR: High HIV testing coverage was achieved in rural Ugandan and Kenyan communities using a hybrid, mobile approach of multi-disease CHCs followed by HBT, which allowed for flexibility at the community and individual level in reaching testing coverage goals.
123 citations
Authors
Showing all 7286 results
Name | H-index | Papers | Citations |
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Pete Smith | 156 | 2464 | 138819 |
Joy E Lawn | 108 | 330 | 55168 |
Philip J. Rosenthal | 104 | 824 | 39175 |
William M. Lee | 101 | 464 | 46052 |
David R. Bangsberg | 97 | 463 | 39251 |
Daniel O. Stram | 95 | 445 | 35983 |
Richard W. Wrangham | 93 | 288 | 29564 |
Colin A. Chapman | 92 | 491 | 28217 |
Ronald H. Gray | 92 | 529 | 34982 |
Donald Maxwell Parkin | 87 | 259 | 71469 |
Larry B. Goldstein | 85 | 434 | 36840 |
Paul Gepts | 78 | 263 | 19745 |
Maria J. Wawer | 77 | 357 | 27375 |
Robert M. Grant | 76 | 437 | 26835 |
Jerrold J. Ellner | 76 | 347 | 17893 |