Makerere University

About: Makerere University is a education organization based out in Kampala, Uganda. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 7220 authors who have published 12405 publications receiving 366520 citations. The organization is also known as: Makerere University Kampala & MUK.

Soybean bioactive components and their implications to health--A review

Abstract: Foods containing bioactive components are receiving increasing attention due to their functionality in disease prevention and treatment. Soybean products contain a plethora of bioactive phytochemicals such as isoflavones, saponins, phytic acids, phytosterols, trypsin inhibitors, and peptides. Research has implicated soybean phytochemicals as functioning in cholesterol reduction, cardiovascular disease prevention, diabetic symptoms prevention, bone loss prevention, and cancer prevention. However, some bioactive compounds in soybean are reported to have some adverse effects to health also. Nevertheless, the benefits of soybean bioactive components exceed by far their potential adverse effects. The main objective of this article is to discuss the different soybean bioactive components and their implications to human health.

The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data

Abstract: Background:Dihydroartemisinin-piperaquine (DP) is increasingly recommended for antimalarial treatment in many endemic countries; however, concerns have been raised over its potential under dosing in young children. We investigated the influence of different dosing schedules on DP's clinical efficacy.Methods and Findings:A systematic search of the literature was conducted to identify all studies published between 1960 and February 2013, in which patients were enrolled and treated with DP. Principal investigators were approached and invited to share individual patient data with the WorldWide Antimalarial Resistance Network (WWARN). Data were pooled using a standardised methodology. Univariable and multivariable risk factors for parasite recrudescence were identified using a Cox's regression model with shared frailty across the study sites. Twenty-four published and two unpublished studies (n = 7,072 patients) were included in the analysis. After correcting for reinfection by parasite genotyping, Kaplan-Meier survival estimates were 97.7% (95% CI 97.3%-98.1%) at day 42 and 97.2% (95% CI 96.7%-97.7%) at day 63. Overall 28.6% (979/3,429) of children aged 1 to 5 years received a total dose of piperaquine below 48 mg/kg (the lower limit recommended by WHO); this risk was 2.3-2.9-fold greater compared to that in the other age groups and was associated with reduced efficacy at day 63 (94.4% [95% CI 92.6%-96.2%], p<0.001). After adjusting for confounding factors, the mg/kg dose of piperaquine was found to be a significant predictor for recrudescence, the risk increasing by 13% (95% CI 5.0%-21%) for every 5 mg/kg decrease in dose; p = 0.002. In a multivariable model increasing the target minimum total dose of piperaquine in children aged 1 to 5 years old from 48 mg/kg to 59 mg/kg would halve the risk of treatment failure and cure at least 95% of patients; such an increment was not associated with gastrointestinal toxicity in the ten studies in which this could be assessed.Conclusions:DP demonstrates excellent efficacy in a wide range of transmission settings; however, treatment failure is associated with a lower dose of piperaquine, particularly in young children, suggesting potential for further dose optimisation.Please see later in the article for the Editors' Summary.

Studies on mixtures of dwarf sorghum and beans ( Phaseolus vulgaris ) with particular reference to plant population

Abstract: An experiment is described in which the possible yield benefits of mixing dwarf sorghum and beans were examined under intensive farming conditions. A ‘replacement series’ of pure sorghum, two-thirds sorghum/one-third beans, one-third sorghum/twothirds beans and pure beans was used at four plant populations. A high level of nitrogen was applied to the sorghum to eliminate the effects of nitrogen transfer from the beans. Yields of the mixtures were up to 55% higher than could be achieved by growing the crops separately. As with some earlier maize/beans experiments (Willey & Osiru, 1972), it is concluded that these yield increases must have been due to a greater utilization of environmental resources. It is suggested that the main factors which made this possible were probably the different rooting depths of the two crops and their different growth cycles. In agreement with the earlier experiments, mixtures which consisted of two-thirds sorghum/one -third beans gave greatest yield increases at high populations and also had a higher optimum population than the pure stands. However, no such trends were apparent in the mixtures which consisted of one-third sorghum/two-thirds beans. For both species intra-specific competition was greater than inter-specific competition. In contrast to the earlier maize/beans experiments, the relative interspecific competitive abilities of the species changed with change in the initial proportions of species in the mixtures. In the two-thirds sorghum/one-third beans mixtures the sorghum was the more competitive species, whilst in the one-third sorghum/two-thirds beans mixtures the bean was the more competitive species. Also in contrast to the maize/beans experiments, these relative competitive abilities were not affected by change in theoverall plant population pressure.

Unravelling the genetic diversity of the three main viruses involved in Sweet Potato Virus Disease (SPVD), and its practical implications.

Abstract: SUMMARY Sweetpotato (Ipomoea batatas) is a widely grown food crop, in which the most important diseases are caused by viruses. Genetic variability of three widely distributed sweetpotato viruses was analysed using data from 46 isolates of Sweet potato feathery mottle virus (SPFMV), 16 isolates of Sweet potato mild mottle virus (SPMMV) and 25 isolates of Sweet potato chlorotic stunt virus (SPCSV), of which 19, seven and six isolates, respectively, are newly characterized. Division of SPFMV into four genetic groups (strains) according to phylogenetic analysis of coat protein (CP) encoding sequences revealed that strain EA contained the East African isolates of SPFMV but none from elsewhere. In contrast, strain RC contained ten isolates from Australia, Africa, Asia and North America. Strain O contained six heterogeneous isolates from Africa, Asia and South America. The seven strain C isolates from Australia, Africa, Asia, and North and South America formed a group that was genetically distant from the other SPFMV strains. SPMMV isolates showed a high level of variability with no discrete strain groupings. SPCSV isolates from East Africa were phylogenetically distant to SPCSV isolates from elsewhere. Only from East Africa were adequate data available for different isolates of the three viruses to estimate the genetic variability of their local populations. The implications of the current sequence information and the need for more such information from most sweetpotato-growing regions of the world are discussed in relation to virus diagnostics and breeding for virus resistance.