Manarom Hospital

About: Manarom Hospital is a healthcare organization based out in Bangkok, Thailand. It is known for research contribution in the topics: Population & Infant mortality. The organization has 3 authors who have published 4 publications receiving 99 citations.

Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population.

Abstract: Background: Lamotrigine (LTG) is commonly used for treatment of epilepsy and bipolar disorder. It is one of the common cause of cutaneous adverse drug reactions (CADR). Clinical symptoms of LTG-induced CADR range from maculopapular exanthema (MPE) to severe cutaneous adverse reactions (SCAR). This study aimed to determine the association of the LTG-induced CADR with human leukocyte antigen (HLA) alleles in Thai patients. Methods: Fifteen patients with LTG-induced CADR [10 MPE; 4 Stevens-Johnson syndrome; and 1 drug reaction with eosinophilia and systemic symptoms] and 50 LTG-tolerant controls were included in the study. HLA-A and HLA-B genotyping was performed using polymerase chain reaction-sequence-specific oligonucleotides probes. Results: The proportion of HLA-A∗02:07 and HLA-B∗15:02 allele carriers were significantly higher in the LTG-induced CADR group than in the tolerant controls [odds ratio (OR): 7.83; 95% confidence interval (CI): 1.60-38.25; P = 0.013, and OR: 4.89; 95% CI: 1.28-18.67; P = 0.014]. In addition, subjects with HLA-A∗33:03, HLA-B∗15:02, and HLA-B∗44:03 were significantly higher in the LTG-induced MPE group than in the tolerant controls (OR: 8.27; 95% CI: 1.83-37.41; P = 0.005, OR: 7.33; 95% CI: 1.63-33.02; P = 0.005; and OR: 10.29; 95% CI: 1.45-72.81; P = 0.029). In contrast to the LTG-induced MPE group, there were no significant differences between HLA alleles and LTG-induced SCAR group. Conclusion:HLA-A∗02:07 and HLA-B∗15:02 were associated with LTG-induced CADR in Thai patients. We also identified an association between HLA-A∗33:03, HLA-B∗15:02, and HLA-B∗44:03 and LTG-induced MPE in this population. These results suggest that these alleles could be useful screening markers for preventing CADR before LTG treatment in Thai patients, but further replication studies with larger sample sizes are needed.

Factors associated with bed sharing and sleep position in Thai neonates.

Abstract: Sleep in a supine position and in a bed separate from but proximate to adults is recommended in several Western countries to prevent Sudden Infant Death Syndrome (SIDS). Cultural differences and a lower rate of SIDS in Asian populations may affect concern with this problem and thus infant sleeping arrangements. The objective was to study bed sharing and sleep position in Thai neonates and the relationship to infant and maternal characteristics. Methods A cross-sectional survey based on interviews with parents of infants aged 21 days old was conducted under the Prospective Cohort Study of Thai Children. Of the total sample 2236/3692 (60.6%) infants shared a bed with their parents. Sixty per cent of the parents placed their infants to sleep in a supine position 32.2% on their side and 4.9% in a prone position. Bed sharing was associated with older maternal age higher education Muslim mother and with work status of professional career or unemployed. Placing the infants to sleep in a prone position was associated with infant birth weight of greater than 2500 g older maternal age higher education Buddhist mother mother with professional career and middle-class household economic status. Infant bed sharing is a common practice in the Thai culture as in other Asian countries. The prone sleep position is less common than in Western populations. The main factor associated with both bed sharing and putting infants to sleep in the prone position was a higher maternal socioeconomic status (SES) in contrast to previous studies in some Western countries in which both practices were associated with low maternal SES. Cultural differences may play an important role in these different findings. (authors)

7th Drug hypersensitivity meeting: part two

Abstract: Table of contentsPoster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)P92 16 years of experience with proton pump inhibitors (PPIs)Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna MartinezP93 Allergy evaluation of quinolone induced adverse reactionsJaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De RojasP94 Bupropion-induced acute urticaria and angioedema, a case reportEmre Ali Acar, Ayse Aktas, Aylin Türel Ermertcan, Peyker TemizP96 Delayed type hypersensitivity and study of cross-reactivity between proton-pump inhibitorsChien-Yio Lin, Chung-Yee Rosaline Hui, Ya-Ching Chang, Chih-Hsun Yang, Wen-Hung ChungP97 Diagnostic work-up in suspected hypersensitivity to proton-pump inhibitors: looking at cross-reactivityFabrícia Carolino, Diana Silva, Eunice Dias De Castro, Josefina R. CernadasP98 Management of infusion-related hypersensitivity reactions to enzyme replacement therapy for lysosomal diseasesLuis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Alex Lacerda, Ana Maria Martins, Ekaterini Goudouris, Marcia Ribeiro, José Francisco Da Silva Franco, Leandra Queiroz, Dirceu SoléP99 Management of insulin allergy with continuous subcutaneous insulin infusionCeyda Tunakan Dalgiç, Aytül Zerrin Sin, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Ali KokuludagP100 Off-label use of icatibant for management of serious angioedema associated with angiotensin inhibitorsAna M. Montoro De Francisco, Talía Mª De Vicente Jiménez, Adriana M. Mendoza Parra, Angella M. Burgos Pimentel, Amelia García LuqueP101 Thiocolchicoside anaphylaxis: an unusual suspect?Luis Amaral, Fabricia Carolino, Leonor Carneiro Leão, Eunice Castro, Josefina CernadasPoster walk 12: betalactam hypersensitivity (P102–P111)P102 A curious delayed reading: a case report of a β-lactam allergy in a childNicole Pinto, Joana Belo, João Marques, Pedro Carreiro-Martins, Paula Leiria-PintoP103 Betalactam-induced hypersensitivity: a 10-years’ experienceAmel Chaabane, Haifa Ben Romdhane, Nadia Ben Fredj, Zohra Chadly, Naceur A. Boughattas, Karim AouamP104 Cefazolin hypersensitivity: towards optimized diagnosisAstrid P. Uyttebroek, Chris H. Bridts, Antonino Romano, Didier G. Ebo, Vito SabatoP105 Clavulanic acid allergy: two cases reportAnabela Lopes, Joana Cosme, Rita Aguiar, Tatiana Lourenço, Maria-João Paes, Amélia Spínola-Santos, Manuel Pereira-BarbosaP106 Diagnosis of betalactam allergy in an allergy departmentCíntia Rito Cruz, Rute Pereira Dos Reis, Elza Tomaz, Ana Paula Pires, Filipe InácioP107 Diagnostic work-up of 410 patients with suspicion of betalactam antibiotic hypersensitivityFilipe Benito-Garcia, Inês Mota, Magna Correia, Ângela Gaspar, Marta Chambel, Susana Piedade, Mário Morais-AlmeidaP108 Immediate selective hypersensitivity reactions to clavulanic acidAlla Nakonechna, Yurij Antipkin, Tetiana Umanets, Fernando Pineda, Francisca Arribas, Volodymyr LapshynP109 Prevalence and incidence of penicillin hypersensitivity reactions in ColombiaPablo Andrés Miranda, Bautista De La Cruz HoyosP110 Selective sensitization to amoxicilin and clavulanic acidJose Julio Laguna Martinez, Aranzazu Jimenez Blanco, Javier Dionicio Elera, Cosmin Boteanu, Rosario Gonzalez-Mendiola, Marta Del PozoP111 Infliximab-specific T cells are detectable also in treated patients who have not developed anti-drug antibodiesAlessandra Vultaggio, Francesca Nencini, Sara Pratesi, Andrea Matucci, Enrico MaggiPoster walk 13: biologicals, local anesthetics, others (P112–P118)P112 A case report of allergic immediate systemic reaction to adalimumab and certolizumabCeyda Tunakan Dalgiç, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Aytül Zerrin Sin, Ali KokuludagP113 Allergy to local anesthetics: negative predictive value of skin testsIvana Cegec, Danica Juricic Nahal, Viktorija Erdeljic Turk, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iva Kraljickovic, Iveta SimicP114 Cutaneous adverse reactions of molecular targeted agents: a retrospective analysis in 150 patients in our departmentYukie Yamaguchi, Tomoya Watanabe, Megumi Satoh, Tomohiko Tanegashima, Kayoko Oda, Hidefumi Wada, Michiko AiharaP115 Generalized paralysis induced by local lidocaine injectionJaechun Jason Lee, Jay Chol Choi, Hwa Young LeeP116 Hypersensitivity to local anaesthetics: a 10 year reviewRosa-Anita Rodrigues Fernandes, Emília Faria, Joana Pita, Nuno Sousa, Carmelita Ribeiro, Isabel Carrapatoso, Ana Todo BomP117 Local anaesthetics: a rare culprit in hypersensitivity reactionsAna Rodolfo, Eunice Dias-Castro, Josefina CernadasP118 Stevens–Johnson syndrome in clinical practice: a variant of clinical courseMarina VoronovaPoster walk 14: RCM (P119–P128)P119 13 cases of severe anaphylactic reactions due to radiocontrast mediaJaume Martí Garrido, Ramon Lopez Salgueiro, Diana Kury Valle, Verónica Pacheco Coronel, Carolina Perales Chordá, Dolores Hernandez Fernandez De RojasP120 Anaphylactic shock after administration of iodinated contrast medium during cardiac catheterizationRoselle Catherine Yu Madamba, Marta Ferrer, Maria Jose Goikoetxea, Carmen D’Amelio, Amalia Bernad, Olga Vega, Gabriel GastaminzaP121 Anaphylactic shock and cardiac arrest induced by gadolinium-based contrast agentsBeatriz Pola Bibián, Marina Lluncor Salazar, Gemma Vilà Nadal, Ana María Fiandor Roman, Javier Dominguez Ortega, Miguel Gonzalez Muñoz, Santiago Quirce Gancedo, Maria Rosario Cabañas MorenoP122 Anaphylaxis to gadobenate and cross-reactivity to other gadolinium-based contrast agents in two patientsKathrin Scherer HofmeierP123 Anaphylaxis to glatiramer acetate in a patient with multiple sclerosisFabrícia Carolino, Vladyslava Barzylovych, Josefina R. CernadasP124 Delayed hypersensitivity reaction to radiocontrast mediaFabrícia Carolino, Diana Silva, Leonor Leão, Josefina R. CernadasP125 Drug reaction with eosinophilia and systemic symptoms induced by iodixanolGemma Vilà-Nadal, Beatriz Pola, Marina Lluncor, Ana Fiandor, Teresa Bellón, Javier Domínguez, Santiago QuirceP126 Electronic consultation support system for radiocontrast media hypersensitivity changes clinician’s behaviorMin-Suk Yang, Sun-Sin Kim, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Yoon-Seok ChangP127 Hypersensitivity reactions to iodinated contrast media: skin testing and follow-upDanica Juricic Nahal, Ivana Cegec, Viktorija Erdeljic Turk, Iva Kraljickovic, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iveta SimicP128 Would iodine allergy exist?Clémence Delahaye, Jenny Flabbee, Julie Waton, Olivia Bauvin, Annick BarbaudPoster walk 15: MPE/type 4 (P129–P137)P129 Delayed hypersensitivity cutaneous reactions: a case/control study from a tunisian databaseKarim Aouam, Najah Ben Fadhel, Zohra Chadly, Nadia Ben Fredj, Naceur A. Boughattas, Amel ChaabaneP130 Delayed hypersensitivity reactions to cephalosporins: a review of seven casesJoana Cosme, Anabela Lopes, Amélia Spínola-Santos, Manuel Pereira-BarbosaP131 Diclofenac induced allergic contact dermatitis: case series of four patientsSandra Jerkovic Gulin, Anca ChiriacP132 Late-onset maculopapular rash to irbesartanBárbara Kong Cardoso, Elza Tomaz, Regina Viseu, Filipe InácioP133 Nonimmediate hypersensitivity reactions to betalactams: a retrospective analysisAna Moreira, Susana Cadinha, Ana Castro Neves, Patricia Barreira, Daniela Malheiro, J. P. Moreira Da SilvaP134 Occupational airborne contact dermatitis to omeprazoleRužica Jurakic-Toncic, Suzana Ljubojevic, Petra TurcicP135 Ornidazole-induced fixed drug eruption confirmed by positive patch test on a residual pigmented lesionLiesbeth Gilissen, Sara Huygens, An GoossensP136 Repeated delayed reaction induced by amoxicillin and amoxicillin clavulanateInmaculada Andreu, Ramon Lopez-Salgueiro, Alicia Martinez Romero, Pau Gomez CabezasP137 Systemic photosensitivity from fenofibrate in a patient photo-sensitized to ketoprofenLiesbeth Gilissen, An GoossensPoster walk 16: HLA genetics (P138–P146)P138 A copy number variation in ALOX5 and PTGER1 is associated with nonsteroidal anti-inflammatory drugs induced urticaria and/or angioedemaPedro Ayuso Parejo, Maria Del Carmen Plaza-Serón, Inmaculada Doña, Natalia Blanca López, Carlos Flores, Luisa Galindo, Ana Molina, James Richard Perkins, Jose Antonio Cornejo-García, José Augusto García-Agúndez, Elena García-Martín, Paloma Campo, María Gabriela Canto, Miguel BlancaP139 Association of galectin-3 (LGALS3) single nucleotide polymorphisms with non-steroidal anti-inflammatory drugs-induced urticaria/angioedemaJosé Antonio Cornejo-Garcia, Inmaculada Doña, Rosa María Guéant-Rodríguez, Natalia Blanca-López, María Carmen Plaza-Serón, Raquel Jurado-Escobar, Esther Barrionuevo, María Salas, María Luisa Galindo, Gabriela Canto, Miguel Blanca, Jean-Louis GuéantP140 Detection of T cell responses to ticlopidine using peripheral blood mononuclear cells from HLA-A*33:03+ healthy donorsToru Usui, Arun Tailor, Lee Faulkner, John Farrell, Ana Alfirevic, B. Kevin Park, Dean J. NaisbittP141 Epistasis approaches to identify novel genes potentially involved in NSAIDs hypersensitivityJames Richard Perkins, Jose Antonio Cornejo García, Oswaldo Trelles, Inmaculada Doña, Esther Barrionuevo, María Salas, María Auxiliadora Guerrero, Miguel Blanca, Alex UptonP142 Genetic predisposition of cold medicine related SJS/TEN with severe ocular complicationsMayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru KinoshitaP143 HLA-B*13:01 and dapsone induced hypersensitivity in Thai populationChonlaphat Chonlaphat Sukasem, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Kulprapat Pairayayutakul, Jettanong KlaewsongkramP144 HLA-B*15:02 alleles and lamotrigine-induced cutaneous adverse drug reactions in ThaiChonlaphat Sukasem