Manchester Metropolitan University

About: Manchester Metropolitan University is a education organization based out in Manchester, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 5435 authors who have published 16202 publications receiving 442561 citations. The organization is also known as: Manchester Polytechnic & MMU.

Learning with digital games : a practical guide to engaging students in higher education

Abstract: Written for Higher Education teaching and learning professionals, Learning with Digital Games provides an accessible, straightforward introduction to the field of computer game-based learning. Up to date with current trends and the changing learning needs of today’s students, this text offers friendly guidance, and is unique in its focus on post-school education and its pragmatic view of the use of computer games with adults.

NF-kB and Inflammatory Cytokine Signalling: Role in Skeletal Muscle Atrophy.

Abstract: Atrophy is a classical hallmark of an array of disorders that affect skeletal muscle, ranging from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and critical illness (sepsis). The loss of muscle mass and function in these instances is associated with disability, poor quality of life and in some cases mortality. The mechanisms which underpin muscle atrophy are complex; however, significant research has demonstrated an important role for inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α), mediated by the generation of reactive oxygen species (ROS) in muscle wasting. Moreover, activation of the transcription factor nuclear factor kappa B (NF-κB) is a key lynchpin in the overall processes that mediate muscle atrophy. The significance of NF-κB as a key regulator of muscle atrophy has been emphasised by several in vivo studies, which have demonstrated that NF-κB-targeted therapies can abrogate muscle atrophy. In this chapter, we will summarise current knowledge on the role of cytokines (TNF-α) and NF-κB in the loss of muscle mass and function and highlight perspectives towards future research and potential therapies to combat muscle atrophy.

Knowledge diffusion dynamics and network properties of face-to-face interactions

Abstract: This paper aims to understand some of the mechanisms which dominate the phenomenon of knowledge diffusion in the process that is called ‘interactive learning’. We examine how knowledge spreads in a network in which agents interact by word of mouth. The social network is structured as a network graph consisting of agents (vertices) and connections (edges) and is situated on a wrapped cellular automata grid forming a torus. The target of this simulation is to test whether knowledge diffuses in a homogeneous way or whether it follows some biased path towards convergence or divergence.

Networks, Communication and Learning during Business Start-up The Creation of Cognitive Social Capital

Abstract: This comparative research examines the characteristics of nascent entrepreneurs' cognitive social capital created via face-to-face and electronic communication.The nascent entrepreneurs had trained...