Manipal University

About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Health care. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.

Biometrics-Based Privacy-Preserving User Authentication Scheme for Cloud-Based Industrial Internet of Things Deployment

Abstract: Due to the widespread popularity of Internet-enabled devices, Industrial Internet of Things (IIoT) becomes popular in recent years. However, as the smart devices share the information with each other using an open channel, i.e., Internet, so security and privacy of the shared information remains a paramount concern. There exist some solutions in the literature for preserving security and privacy in IIoT environment. However, due to their heavy computation and communication overheads, these solutions may not be applicable to wide category of applications in IIoT environment. Hence, in this paper, we propose a new biometric-based privacy preserving user authentication (BP2UA) scheme for cloud-based IIoT deployment. BP2UA consists of strong authentication between users and smart devices using preestablished key agreement between smart devices and the gateway node. The formal security analysis of BP2UA using the well-known real-or-random model is provided to prove its session key security. Moreover, an informal security analysis of BP2UA is also given to show its robustness against various types of known attacks. The computation and communication costs of BP2UA in comparison to the other existing schemes of its category demonstrate its effectiveness in the IIoT environment. Finally, the practical demonstration of BP2UA is also done using the NS2 simulation.

Review of even element super-heavy nuclei and search for element 120

Abstract: The reaction 54Cr$ + $248Cm was investigated at the velocity filter SHIP at GSI, Darmstadt, with the intention to study production and decay properties of isotopes of element 120. Three correlated signals were measured, which occurred within a period of 279ms. The heights of the signals correspond with the expectations for a decay sequence starting with an isotope of element 120. However, a complete decay chain cannot be established, since a signal from the implantation of the evaporation residue cannot be identified unambiguously. Measured properties of the event chain are discussed in detail. The result is compared with theoretical predictions. Previously measured decay properties of even element super-heavy nuclei were compiled in order to find arguments for an assignment from the systematics of experimental data. In the course of this review, a few tentatively assigned data could be corrected. New interpretations are given for results which could not be assigned definitely in previous studies. The discussion revealed that the cross-section for production of element 120 could be high enough so that a successful experiment seems possible with presently available techniques. However, a continuation of the experiment at SHIP for a necessary confirmation of the results obtained in a relatively short irradiation of five weeks is not possible at GSI presently. Therefore, we decided to publish the results of the measurement and of the review as they exist now. In the summary and outlook section we also present concepts for the continuation of research in the field of super-heavy nuclei.

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.

Abstract: BACKGROUND: Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption in this process can lead to the development of various chronic diseases, including cancer. In cancer, aberrant angiogenesis plays a prominent role in maintaining sustained tumor growth to malignant phenotypes and promoting metastasis. The leakiness in the tumor microvasculature is attributed to the tumor cells migrating to distal site organs and forming colonies. METHODS: In this article, we briefly review the various mediators involved in the angiogenic process and the anti-angiogenic potential of selected natural compounds against various malignancies. RESULTS: Several growth factors and their receptors such as vascular endothelial growth factor and receptor (VEGF/VEGFR), basic fibroblast growth factor and receptor (bFGF/FGFR), angiopoietins, and hypoxia inducible factors facilitate the development of angiogenesis and are attractive anti-cancer targets. Natural products represent a rich diversity of compounds for drug discovery and are currently being actively exploited to target tumor angiogenesis. CONCLUSION: Agents such as curcumin, artemisinin and its semi-synthetic derivatives, EGCG, pentacyclic triterpenoids, resveratrol, emodin, celastrol, thymoquinone and tocotrienols all have shown prominent anti-angiogenic effects in the preclinical models of tumor angiogenesis. Several semi-synthetic derivatives and novel nano-formulations of natural compounds have also exhibited excellent anti-angiogenic activity by increasing bioavailability and delivering the drugs to the sites of tumor angiogenesis.