Institution
Manipal University
Education•Manipal, Karnataka, India•
About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Health care. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.
Topics: Population, Health care, Cancer, Medicine, Drug delivery
Papers published on a yearly basis
Papers
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TL;DR: Transdermal delivery has all the necessities that are required for delivery of classical antihypertensive agents, but the different approaches to enhance the transport of atenolol through intact skin have not resulted in a remarkable improvement.
Abstract: Background/purpose: Oral therapy with antihypertensive agents is generally associated with severe GI side effects and low patient compliance. Therefore, development of a method of drug delivery that maintains the proper drug level for a prolonged period without adverse effects is required. Thus, transdermal delivery has all the necessities that are required for delivery of classical antihypertensive agents. However, the different approaches to enhance the transport of atenolol through intact skin have not resulted in a remarkable improvement.
Methods: The effect of the drug concentration and a binary system (water–ethanol) on the atenolol flux was investigated. Further, the effects of chemical enhancers (menthol, oleic acid, polyethylene glycol 400, sodium lauryl sulphate, di methyl formamide and N-methyl-2-pyrrolidone) at different concentrations and their combined effects with iontophoresis were examined.
Results: Among the binary systems, the highest flux was obtained when 75% v/v ethanol in water was used. Atenolol flux enhanced significantly (P<0.001) at the 5% w/v concentration among all the enhancers studied. It was also observed that the combination of iontophoresis with oleic acid (5% w/v) showed the maximum benefit with a steady-state flux of 2.66 μmol/cm2/h.
Conclusion: The combination of iontophoresis with permeation enhancers was found to be promising in delivering atenolol across the skin, and the highest permeation was attained when oleic acid was combined with iontophoresis. The in vitro flux value obtained (when oleic acid combined with iontophoresis) was 0.71 mg/cm2/h, which points to the fact that a therapeutically effective concentration can be attained with 1.2 cm2 of skin contact area.
43 citations
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TL;DR: Three flight-activated central dopaminergic interneurons in the ventral ganglion connect to and activate motoneurons that innervate a pair of direct-steering flight muscles that control the motor circuit for Drosophila wing movement.
43 citations
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43 citations
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TL;DR: In this paper, a review of different feedstock suitable for hydrothermal carbonization (HTC) that are experimentally investigated and classifies them into five categories like woody biomass, plant biomass, agricultural biomass, algae, and municipal solid waste (MSW).
43 citations
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TL;DR: In this article, the authors provide evidence for epigenetic mechanisms utilized by several potential drugs for non-alcoholic fatty liver disease (NAFLD) and discuss the high plasticity of epigenetic modifications in response to environmental cues.
43 citations
Authors
Showing all 9740 results
Name | H-index | Papers | Citations |
---|---|---|---|
John J.V. McMurray | 178 | 1389 | 184502 |
Ashok Kumar | 151 | 5654 | 164086 |
Zhanhu Guo | 128 | 886 | 53378 |
Vijay P. Singh | 106 | 1699 | 55831 |
Michael Walsh | 102 | 963 | 42231 |
Akhilesh Pandey | 100 | 529 | 53741 |
Vivekanand Jha | 94 | 958 | 85734 |
Manuel Hidalgo | 92 | 538 | 41330 |
Madhukar Pai | 89 | 522 | 33349 |
Ravi Kumar | 82 | 571 | 37722 |
Vijay V. Kakkar | 60 | 470 | 17731 |
G. Münzenberg | 58 | 336 | 9837 |
Abhishek Sharma | 52 | 426 | 9715 |
Ramesh R. Bhonde | 49 | 223 | 8397 |
Chandra P. Sharma | 48 | 325 | 12100 |