Manipal University

About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Medicine. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.

Mechanical properties and sliding wear behavior of jatropha seed cake waste/epoxy composites

Abstract: Jatropha seed cake particulate (JSCP)-reinforced epoxy composites were prepared by open mold resin casting method. The influence of JSCP on mechanical and dry sliding wear properties of epoxy was experimentally investigated as per the ASTM standards. Dry sliding wear test was conducted for these composites at a constant sliding distance of 500 m with different sliding velocities and applied loads by a pin-on-disc wear test machine. The results revealed that incorporation of JSCP decreased the specific wear rate and coefficient of friction while improving the mechanical properties. The composite reinforced with 40 wt% of JSCP exhibited better mechanical properties and wear behavior compared to the neat epoxy and other compositions of JSCP/epoxy composites. The results of this study indicate that jatropha seed cake powder can be used as biosolid lubricant filler for epoxy.

Advances in self-assembled injectable hydrogels for cancer therapy.

Abstract: Non-specific toxicity of chemotherapeutics and evolution of malignant tumors against them are major challenges for existing cancer chemotherapeutic regimens. Engineering of nanomaterials has attempted to minimize the toxicity of anticancer drugs, but systemic delivery of these nanomaterials still imposes many hurdles in their clinical use like burst release of chemotherapeutics and toxicity and immunogenicity associated with excipients of nanomaterials. However, there has been a surge in the development of natural and synthetic nanomaterials to deliver anticancer agents to the diseased (tumor) site as it can minimize the systemic circulation of anticancer drugs and reduce the toxicity-related challenges. Therefore, localized drug delivery is considered as the most effective way to deliver therapeutics but is further challenged by poor biodegradability, high immunogenicity, poor drug entrapment efficacy and inability to maintain sustained release of anticancer agents at the tumor site. This review maps out recent advancements in engineering of low molecular weight hydrogels derived from amino acid, fatty acyl, steroidal lipid and drug conjugated amphiphilic scaffolds. We have summarized the efforts for the development of molecular hydrogels in terms of biocompatibility, therapeutic potential and challenges associated with existing molecular hydrogels for cancer therapy.

Action-embedded pedagogy in entrepreneurship education: an experimental enquiry

Abstract: Scholarly community has raised concerns over the effectiveness of traditional classroom pedagogy in entrepreneurship education (EE), highlighting the need for alternative pedagogic approach. Our st...