Institution
Manipal University
Education•Manipal, Karnataka, India•
About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Health care. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.
Topics: Population, Health care, Cancer, Medicine, Drug delivery
Papers published on a yearly basis
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TL;DR: There were no significant differences between the self-reported oral hygiene knowledge and practices among medical and engineering university students, but the knowledge levels of the students were considerably lower than expected.
Abstract: AIM This study was conducted to test the null hypothesis that no difference exists in the oral hygiene knowledge and practices of university students in different courses when they have equal opportunity to access health-promotive dental care METHODS AND MATERIALS The study was conducted using 120 students each from the medical and engineering colleges at the University of Manipal Academy of Higher Education who had easy access to the dental college within the campus which provides health-promotive dental care to all its patients A self-administered structured questionnaire consisting of questions on demographic data, oral hygiene knowledge and practices, and dental service utilization patterns was distributed among the students The data collected was analyzed using SPSS 10 version RESULTS Statistically significant differences were found between the two groups with respect to the knowledge of fluoridated toothpastes, frequency of toothbrush renewal, use of dental floss, and a tongue cleaner (p < 0001) The groups were similar in all other practices including the utilization of dental services There were no significant differences between the self-reported oral hygiene knowledge and practices among medical and engineering university students, but the knowledge levels of the students were considerably lower than expected
41 citations
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TL;DR: In this article, a new criterion has been formulated to delineate the cation-π interactions based on the distribution of atoms in the π system (5 and 6-member rings) of DNA bases around the positive charged atoms of Lys and Arg and the energetic contribution of contacting atoms from electrostatic and van der Waals interactions.
41 citations
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TL;DR: In this article, a review of heavy element research with SHIP at GSI is reviewed including the discovery of the chemical elements bohrium to copernicium, experimental developments, cold fusion of heavy ions, and discovery of a shell region around hassium.
41 citations
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TL;DR: There was an overall increase in the production of virulence factors among non-albicans Candida, and identification of clinical isolates of Candida up to species level either by chromogenic agar or by Vitek 2 Compact system should be routinely done to choose appropriate therapy.
Abstract: Candida spp. have emerged as successful pathogens in both invasive and mucosal infections. Varied virulence factors and growing resistance to antifungal agents have contributed to their pathogenicity. We studied diagnostic accuracy of HiCrome Candida Differential Agar and Vitek 2 Compact system for identification of Candida spp. in comparison with species-specific PCR on 110 clinical isolates of Candida from blood stream infections (54, 49%) and vulvovaginal candidiasis (56, 51%). C. albicans (61%) was the leading pathogen in VVC, while C. tropicalis (46%) was prominent among BSIs. HiCrome Agar and Vitek 2 Compact had good measures of agreement (κ) 0.826 and 0.895, respectively, in comparison with PCR. We also tested these isolates for in vitro production of proteinase, esterase, phospholipases, and biofilms. Proteinase production was more among invasive isolates (), while phospholipase production was more among noninvasive isolates (). There was an overall increase in the production of virulence factors among non-albicans Candida. Identification of clinical isolates of Candida up to species level either by chromogenic agar or by Vitek 2 Compact system should be routinely done to choose appropriate therapy.
41 citations
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TL;DR: The results suggest that induction of PRDM2 in G0 ensures that two antagonistic programs—myogenesis and the cell cycle—while stalled, are poised for reactivation, with implications for stem cell self-renewal.
Abstract: Adult stem cell quiescence is critical to ensure regeneration while minimizing tumorigenesis. Epigenetic regulation contributes to cell cycle control and differentiation, but few regulators of the chromatin state in quiescent cells are known. Here we report that the tumor suppressor PRDM2/RIZ, an H3K9 methyltransferase, is enriched in quiescent muscle stem cells in vivo and controls reversible quiescence in cultured myoblasts. We find that PRDM2 associates with >4400 promoters in G0 myoblasts, 55% of which are also marked with H3K9me2 and enriched for myogenic, cell cycle and developmental regulators. Knockdown of PRDM2 alters histone methylation at key promoters such as Myogenin and CyclinA2 (CCNA2), and subverts the quiescence program via global de-repression of myogenesis, and hyper-repression of the cell cycle. Further, PRDM2 acts upstream of the repressive PRC2 complex in G0. We identify a novel G0-specific bivalent chromatin domain in the CCNA2 locus. PRDM2 protein interacts with the PRC2 protein EZH2 and regulates its association with the bivalent domain in the CCNA2 gene. Our results suggest that induction of PRDM2 in G0 ensures that two antagonistic programs—myogenesis and the cell cycle—while stalled, are poised for reactivation. Together, these results indicate that epigenetic regulation by PRDM2 preserves key functions of the quiescent state, with implications for stem cell self-renewal.
41 citations
Authors
Showing all 9740 results
Name | H-index | Papers | Citations |
---|---|---|---|
John J.V. McMurray | 178 | 1389 | 184502 |
Ashok Kumar | 151 | 5654 | 164086 |
Zhanhu Guo | 128 | 886 | 53378 |
Vijay P. Singh | 106 | 1699 | 55831 |
Michael Walsh | 102 | 963 | 42231 |
Akhilesh Pandey | 100 | 529 | 53741 |
Vivekanand Jha | 94 | 958 | 85734 |
Manuel Hidalgo | 92 | 538 | 41330 |
Madhukar Pai | 89 | 522 | 33349 |
Ravi Kumar | 82 | 571 | 37722 |
Vijay V. Kakkar | 60 | 470 | 17731 |
G. Münzenberg | 58 | 336 | 9837 |
Abhishek Sharma | 52 | 426 | 9715 |
Ramesh R. Bhonde | 49 | 223 | 8397 |
Chandra P. Sharma | 48 | 325 | 12100 |