Manipal University

About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Health care. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.

Mental Health Literacy Among Late Adolescents in South India: What They Know and What Attitudes Drive Them:

Abstract: Background: Early recognition of mental health problems gives an individual the opportunity for better long-term outcomes if intervention is initiated early. Mental health literacy is a related concept which is increasingly seen as an important measure of the awareness and knowledge of mental health disorders. Aim and Objectives: This study aimed at assessing the mental health literacy, help-seeking behavior and beliefs and attitudes related to mental illnesses among adolescents attending preuniversity colleges. Materials and Methods: A cross-sectional study was conducted among randomly selected preuniversity college students (n = 916). Data were collected through self-administered questionnaires. Data were computed using STATA. Analysis and interpretation were carried out using descriptives and Chi-square test. Results: Of the 916 respondents, 54.15% were male while 45.85% were female. The majority (78.60%) of the respondents ascribed to the Hindu religion, hailed largely from rural areas (57.21%) and were mostly studying in the 11th standard (72.49%).The percentage of mental health literacy among the respondents was very low, i.e., depression was identified by 29.04% and schizophrenia/psychosis was recognized by 1.31%. The study findings indicate that adolescents preferred reaching out more to informal sources including family members such as mothers than formal sources for self than for others indicating deeply prevalent stigmatizing attitudes toward mental health conditions. Conclusions: There is a need for immediate improvement in the knowledge of adolescents on mental health literacy which suggests that programs need to be developed such that adolescents can seek help from valid resources if the need were to arise and have appropriate knowledge on whom to approach for help.

Vibration based condition monitoring of rotating machinery

Abstract: This project looks at the different maintenance philosophies and the importance of vibration analysis in predictive maintenance. Since most industries and plants make use of rotational equipment, vibration analysis plays a major role in detecting machine defects and developing flaws before the equipment fails and potentially damages other related equipment and to avoid unwanted breakdowns and downtime. Vibration analysis can help increase the lifetime of equipment when the faults are diagnosed at the right time. Vibration analysis of a rotating table top model is also done to show that some faults might exist even though they are not visible to the naked eye.

Expansion and characterization of bone marrow derived human mesenchymal stromal cells in serum-free conditions.

Abstract: Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are gaining increasing importance in the field of regenerative medicine Although therapeutic value of MSCs is now being established through many clinical trials, issues have been raised regarding their expansion as per regulatory guidelines Fetal bovine serum usage in cell therapy poses difficulties due to its less-defined, highly variable composition and safety issues Hence, there is a need for transition from serum-based to serum-free media (SFM) Since SFM are cell type-specific, a precise analysis of the properties of MSCs cultured in SFM is required to determine the most suitable one Six different commercially available low serum/SFM with two different seeding densities were evaluated to explore their ability to support the growth and expansion of BM-MSCs and assess the characteristics of BM-MSCs cultured in these media Except for one of the SFM, all other media tested supported the growth of BM-MSCs at a low seeding density No significant differences were observed in the expression of MSC specific markers among the various media tested In contrary, the population doubling time, cell yield, potency, colony-forming ability, differentiation potential, and immunosuppressive properties of MSCs varied with one another We show that SFM tested supports the growth and expansion of BM-MSCs even at low seeding density and may serve as possible replacement for animal-derived serum

Knowledge and practices of postnatal mothers on newborn care in tertiary care hospital of Udupi district

Abstract: A descriptive correlational survey to assess knowledge and practice of postnatal mothers on newborn care was carried out among 30 mothers using valid, reliable, structured knowledge and practice questionnaire. The collected data was analyzed using SPSS version 16. The findings of the study showed that most of the sample 24(80%) were in the age group 21-30 years, most of them 16(53.3%) were primipara, 15(50%) had normal vaginal delivery and 15 (50%) had LSCS. Majority of the sample 25 (83.3%) belonged to Hindu religion, most of them 19 (63.3%) belonged to joint family, most the samples 17 (56.7%) lived in a rural area, majority of the mothers 17 (56.7%) were housewives. Majority of the new- borns, 24 (80%) were above 37 weeks of gestation, most of the new born 21(70%) were below 6 days of age, majority of the new born 19(63.3%) were male, majority of newborn 16(53.3%) were above 3000 grams of birth weight. Majority 23 (76.7%) of mothers had good knowledge on new-born care. Most of 16 (53.33%) of mothers had excellent practice on newborn care. Relationship between knowledge and practice score of the mother was not statistically significant at 0.05 level (r=0.276, p=0.140). The education of the mothers (x2(df) =11.642(3), p=0.009) had significant association with the knowledge of the mother regarding new-born care. Keeping in mind the findings of the study it is recommended that an educational programme regarding newborn care can be organized to the antenatal and postnatal mothers

Effect of age, comorbidity and remission status on outcome of COVID-19 in patients with hematological malignancies.

Abstract: Background There is scarcity of data on outcome of COVID-19 in patients with hematological malignancies. Primary objective of study was to analyse the 14-day and 28-day mortality. Secondary objectives were to correlate age, comorbidities and remission status with outcome. Methods Retrospective multicentre observational study conducted in 11 centres across India. Total 130 patients with hematological malignancies and COVID-19 were enrolled. Results Fever and cough were commonest presentation. Eleven percent patients were incidentally detected. Median age of our cohort was 49.5 years. Most of our patients had a lymphoid malignancy (n = 91). One-half patients (52%) had mild infection, while moderate and severe infections contributed to one-fourth each. Sixty seven patients (52%) needed oxygen For treatment of COVID-19 infection, half(n = 66) received antivirals. Median time to RT-PCR COVID-19 negativity was 17 days (7–49 days). Nearly three-fourth (n = 95) of our patients were on anticancer treatment at time of infection, of which nearly two-third (n = 59;64%) had a delay in chemotherapy. Overall, 20% (n = 26) patients succumbed. 14-day survival and 28-day survival for whole cohort was 85.4% and 80%, respectively. One patient succumbed outside the study period on day 39. Importantly, death rate at 1 month was 50% and 60% in relapse/refractory and severe disease cohorts, respectively. Elderly patients(age ≥ 60) (p = 0.009), and severe COVID-19 infection (p = 0.000) had a poor 14-day survival. The 28-day survival was significantly better for patients in remission (p = 0.04), non-severe infection (p = 0.00), and age Conclusions Elderly patients with hematological malignancy and severe covid-19 have worst outcomes specially when disease is not in remission.