Institution
Manipal University
Education•Manipal, Karnataka, India•
About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Medicine. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.
Topics: Population, Medicine, Computer science, Health care, Cancer
Papers published on a yearly basis
Papers
More filters
TL;DR: This study investigates co-amorphous formulations from the viewpoint of solid dispersions, describes their formation and mechanism of stabilization, study their impact on dissolution and in vivo performance and briefly outline the future potentials.
327 citations
TL;DR: An eighteen layer CNN framework is proposed for glaucoma diagnosis with the highest accuracy of 98.13% using 1426 fundus images, which demonstrates the robustness of the system, which can be used as a supplementary tool for the clinicians to validate their decisions.
325 citations
TL;DR: An automated detection system for Parkinson’s disease employing the convolutional neural network (CNN) employing the thirteen-layer CNN architecture which can overcome the need for the conventional feature representation stages is proposed.
Abstract: An automated detection system for Parkinson’s disease (PD) employing the convolutional neural network (CNN) is proposed in this study. PD is characterized by the gradual degradation of motor function in the brain. Since it is related to the brain abnormality, electroencephalogram (EEG) signals are usually considered for the early diagnosis. In this work, we have used the EEG signals of twenty PD and twenty normal subjects in this study. A thirteen-layer CNN architecture which can overcome the need for the conventional feature representation stages is implemented. The developed model has achieved a promising performance of 88.25% accuracy, 84.71% sensitivity, and 91.77% specificity. The developed classification model is ready to be used on large population before installation of clinical usage.
317 citations
TL;DR: In all the models tested, berberine showed its ability to scavenge the free radicals in a concentration dependent manner, which justifies the therapeutic potential of berberines.
Abstract: Berberine is a benzyl tetra isoquinoline alkaloid which is widely used as an antimicrobial and an antidiarrhoeal. As berberine containing plants are virtually used in all forms of traditional medicine, our study aimed to examine the antioxidant activity of berberine using 2,2-diphenyl 1-picrylhydrazyl (DPPH) radical scavenging, nitric oxide scavenging, lipid peroxidation, superoxide scavenging, iron chelating activity and 2,2-azino bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical scavenging methods. The IC(50) values for all the models were calculated by regression analysis. In all the models tested, berberine showed its ability to scavenge the free radicals in a concentration dependent manner. The present study thereby justifies the therapeutic potential of berberine.
309 citations
TL;DR: It is shown that transbilayer interactions are necessary for the generation of cholesterol-dependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dynamic actin filaments, and it is found that long saturated acyl-chains are required for forming G PI-anchor Nanoclusters.
308 citations
Authors
Showing all 9740 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John J.V. McMurray | 178 | 1389 | 184502 |
| Ashok Kumar | 151 | 5654 | 164086 |
| Zhanhu Guo | 128 | 886 | 53378 |
| Vijay P. Singh | 106 | 1699 | 55831 |
| Michael Walsh | 102 | 963 | 42231 |
| Akhilesh Pandey | 100 | 529 | 53741 |
| Vivekanand Jha | 94 | 958 | 85734 |
| Manuel Hidalgo | 92 | 538 | 41330 |
| Madhukar Pai | 89 | 522 | 33349 |
| Ravi Kumar | 82 | 571 | 37722 |
| Vijay V. Kakkar | 60 | 470 | 17731 |
| G. Münzenberg | 58 | 336 | 9837 |
| Abhishek Sharma | 52 | 426 | 9715 |
| Ramesh R. Bhonde | 49 | 223 | 8397 |
| Chandra P. Sharma | 48 | 325 | 12100 |