Institution
Manipal University
Education•Manipal, Karnataka, India•
About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Health care. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.
Topics: Population, Health care, Cancer, Medicine, Drug delivery
Papers published on a yearly basis
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TL;DR: A novel series of heterocyclic o/m/p substituted diphenyl ether derivatives appear to have a novel mechanism of action against M. tuberculosis, and their structural features should be studied further for their potential use as new antitubercular drugs.
94 citations
TL;DR: This work uncovers a critical function of DDX3 and provides a new role in m6 demethylation of RNA and a combination regimen of ketorolac salt with cisplatin deserves further clinical investigation in advanced OSCC.
Abstract: Platinum based drugs alone or in combination with 5FU and docetaxel are common regimen chemotherapeutics for the treatment of advanced OSCC. Chemoresistance is one of the major factors of treatment failure in OSCC. Human RNA helicase DDX3 plays an important role in cell proliferation, invasion, and metastasis in several neoplasms. The potential role of DDX3 in chemoresistance is yet to be explored. Enhanced cancer stem cells (CSCs) population significantly contributes to chemoresistance and recurrence. A recent study showed that m6A RNA regulates self-renewal and tumorigenesis property in cancer. In this study we found genetic (shRNA) or pharmacological (ketorolac salt) inhibition of DDX3 reduced CSC population by suppressing the expression of FOXM1 and NANOG. We also found that m6A demethylase ALKBH5 is directly regulated by DDX3 which leads to decreased m6A methylation in FOXM1 and NANOG nascent transcript that contribute to chemoresistance. Here, we found DDX3 expression was upregulated in both cisplatin-resistant OSCC lines and chemoresistant tumors when compared with their respective sensitive counterparts. In a patient-derived cell xenograft model of chemoresistant OSCC, ketorolac salt restores cisplatin-mediated cell death and facilitates a significant reduction of tumor burdens. Our work uncovers a critical function of DDX3 and provides a new role in m6 demethylation of RNA. A combination regimen of ketorolac salt with cisplatin deserves further clinical investigation in advanced OSCC.
94 citations
Mayo Clinic1, Hospital General Universitario Gregorio Marañón2, Qatar University3, Keele University4, Universidade Federal de Minas Gerais5, German Sport University Cologne6, International Olympic Committee7, Manipal University8, National University of Singapore9, University of the West Indies10, University of Iceland11, University of Banja Luka12, Betsi Cadwaladr University Health Board13, Aristotle University of Thessaloniki14, Marmara University15, Inje University16, Fu Jen Catholic University17, University of Auckland18, Tbilisi State Medical University19, Isfahan University of Medical Sciences20, Palacký University, Olomouc21, Oulu University Hospital22, Lithuanian University of Health Sciences23, Edinburgh Napier University24, Shaare Zedek Medical Center25, Norfolk and Norwich University Hospital26, Frederiksberg Hospital27, Cardiovascular Institute of the South28, Karolinska Institutet29, University of British Columbia30, Moncton Hospital31, Beijing United Family Hospital32, University Health Network33
TL;DR: This first-ever survey of CR around the globe suggests CR quality is high, however, there is significant regional variation, which could impact patient outcomes.
94 citations
TL;DR: It is concluded that, ECM proteins indeed modified the growth patterns and induced the osteoblast differentiation of hMSCs and have significant implication for bone tissue engineering applications.
93 citations
TL;DR: Several products derived from natural sources modulate the expression and activity of multiple transcription factors in various tumor models as evident from studies conducted in cell lines, pre‐clinical models and clinical samples.
93 citations
Authors
Showing all 9740 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John J.V. McMurray | 178 | 1389 | 184502 |
| Ashok Kumar | 151 | 5654 | 164086 |
| Zhanhu Guo | 128 | 886 | 53378 |
| Vijay P. Singh | 106 | 1699 | 55831 |
| Michael Walsh | 102 | 963 | 42231 |
| Akhilesh Pandey | 100 | 529 | 53741 |
| Vivekanand Jha | 94 | 958 | 85734 |
| Manuel Hidalgo | 92 | 538 | 41330 |
| Madhukar Pai | 89 | 522 | 33349 |
| Ravi Kumar | 82 | 571 | 37722 |
| Vijay V. Kakkar | 60 | 470 | 17731 |
| G. Münzenberg | 58 | 336 | 9837 |
| Abhishek Sharma | 52 | 426 | 9715 |
| Ramesh R. Bhonde | 49 | 223 | 8397 |
| Chandra P. Sharma | 48 | 325 | 12100 |