Institution
Manipal University
Education•Manipal, Karnataka, India•
About: Manipal University is a education organization based out in Manipal, Karnataka, India. It is known for research contribution in the topics: Population & Health care. The organization has 9525 authors who have published 11207 publications receiving 110687 citations.
Topics: Population, Health care, Cancer, Medicine, Drug delivery
Papers published on a yearly basis
Papers
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TL;DR: It is shown that by this method all the four tissue types could be discriminated and diagnosed correctly and the biochemical differences between normal and pathological conditions of oral tissue are discussed from spectral differences of the different classes of spectra.
Abstract: Optical spectroscopy methods are fast emerging as potential alternatives for early diagnosis of cancer. A Raman spectroscopy method for discrimination of normal and malignant oral tissues has been developed by us earlier. It is necessary to evaluate and establish the validity of the approach before it can be routinely used. In the present study, our Raman spectroscopy investigations are extended further to evaluate the efficacy of the technique to discriminate between normal, inflammatory, premalignant, and malignant conditions in oral tissue. Spectral profiles of normal, malignant, premalignant, and inflammatory conditions show pronounced differences between one another. Spectra of normal tissues can be attributed mainly to lipids whereas pathological tissue spectra are dominated by proteins. Principal components analysis (PCA) of the spectral data sets belonging to the four different categories showed that scores of factors differentiated between normal and all pathological conditions but gave only poor discrimination among the three pathological states. PCA combined with multiparameter limit tests allow match/mismatch criteria to be applied to test samples when pathologically certified calibration sets are available in each class. It is shown that by this method all the four tissue types could be discriminated and diagnosed correctly. The biochemical differences between normal and pathological conditions of oral tissue are also discussed from spectral differences of the different classes of spectra.
284 citations
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TL;DR: A novel role is proposed for MSC secreted factors induced at the MSC-macrophage interface in re-educating macrophage by manipulating metabolic programs in differentially polarized macrophages.
Abstract: Mesenchymal stem cells (MSCs) are speculated to act at macrophage-injury interfaces to mediate efficient repair. To explore this facet in-depth this study evaluates the influence of MSCs on human macrophages existing in distinct functional states. MSCs promoted macrophage differentiation, enhanced respiratory burst and potentiated microbicidal responses in naive macrophages (Mφ). Functional attenuation of inflammatory M1 macrophages was associated with a concomitant shift towards alternatively activated M2 state in MSC-M1 co-cultures. In contrast, alternate macrophage (M2) activation was enhanced in MSC-M2 co-cultures. Elucidation of key macrophage metabolic programs in Mo/MSC, M1/MSC and M2/MSC co-cultures indicated changes in Glucose transporter1 (GLUT1 expression/glucose uptake, IDO1 protein/activity, SIRTUIN1 and alterations in AMPK and mTOR activity, reflecting MSC-instructed metabolic shifts. Inability of Cox2 knockdown MSCs to attenuate M1 macrophages and their inefficiency in instructing metabolic shifts in polarized macrophages establishes a key role for MSC-secreted PGE2 in manipulating macrophage metabolic status and plasticity. Functional significance of MSC-mediated macrophage activation shifts was further validated on human endothelial cells prone to M1 mediated injury. In conclusion, we propose a novel role for MSC secreted factors induced at the MSC-macrophage interface in re-educating macrophages by manipulating metabolic programs in differentially polarized macrophages.
282 citations
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TL;DR: A compendium of potential biomarkers that can be systematically validated by the pancreatic cancer community is described.
Abstract: Akhilesh Pandey and colleagues describe a compendium of potential biomarkers that can be systematically validated by the pancreatic cancer community.
281 citations
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Tulane University1, Kurume University2, Manipal University3, Okayama University4, New Generation University College5, Yonsei University6, Gdańsk Medical University7, All India Institute of Medical Sciences8, University of Bari9, Stowers Institute for Medical Research10, University of Kansas11, Complutense University of Madrid12, Ankara University13, Ege University14, University of Utah15, Jagiellonian University Medical College16, St. George's University17, University of Rouen18, University of Erlangen-Nuremberg19, University of La Frontera20, St George's, University of London21, Northern Borders University22
TL;DR: Twenty editors‐in‐chiefs from 17 anatomical journals joined together to put together official recommendations that can be used by authors when acknowledging the donor cadavers used in their studies to standardize the writing approach by which donors are acknowledged in anatomical studies that use human cadaveric tissues.
Abstract: Research within the anatomical sciences often relies on human cadaveric tissues. Without the good will of these donors who allow us to use their bodies to push forward our anatomical knowledge, most human anatomical research would come to a standstill. However, many research papers omit an acknowledgement to the donor cadavers or, as no current standardized versions exist, use language that is extremely varied. To remedy this problem, 20 editors-in-chiefs from 17 anatomical journals joined together to put together official recommendations that can be used by authors when acknowledging the donor cadavers used in their studies. The goal of these recommendations is to standardize the writing approach by which donors are acknowledged in anatomical studies that use human cadaveric tissues. Such sections in anatomical papers will not only rightfully thank those who made the donation but might also encourage, motivate, and inspire future individuals to make such gifts for the betterment of the anatomical sciences and patient care.
266 citations
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TL;DR: In this paper, a review of recent achievements for carbon materials with different microstructures as electromagnetic interference shielding materials (ESMs) and microwave absorption materials (MAMs) during the past five years is presented.
265 citations
Authors
Showing all 9740 results
Name | H-index | Papers | Citations |
---|---|---|---|
John J.V. McMurray | 178 | 1389 | 184502 |
Ashok Kumar | 151 | 5654 | 164086 |
Zhanhu Guo | 128 | 886 | 53378 |
Vijay P. Singh | 106 | 1699 | 55831 |
Michael Walsh | 102 | 963 | 42231 |
Akhilesh Pandey | 100 | 529 | 53741 |
Vivekanand Jha | 94 | 958 | 85734 |
Manuel Hidalgo | 92 | 538 | 41330 |
Madhukar Pai | 89 | 522 | 33349 |
Ravi Kumar | 82 | 571 | 37722 |
Vijay V. Kakkar | 60 | 470 | 17731 |
G. Münzenberg | 58 | 336 | 9837 |
Abhishek Sharma | 52 | 426 | 9715 |
Ramesh R. Bhonde | 49 | 223 | 8397 |
Chandra P. Sharma | 48 | 325 | 12100 |