Showing papers by "Marche Polytechnic University published in 1997"
TL;DR: In patients with paroxysmal AF not controlled by pharmacological therapy, Abl+Pm treatment is highly effective and superior to drug therapy in controlling symptoms and improving quality of life.
Abstract: Background The purpose of the study was to evaluate the effect of AV junction ablation and pacemaker implantation on quality of life and specific symptoms in patients with paroxysmal atrial fibrillation (AF) not controlled by drugs. Methods and Results We performed a multicenter, randomized, 6-month evaluation of the clinical effects of AV junction ablation and DDDR mode-switching pacemaker (Abl+Pm) versus pharmacological treatment in 43 patients with intolerable, recurrent paroxysmal AF of three or more episodes in the previous 6 months not controlled with three or more antiarrhythmic drugs. Before completion of the study, 3 patients in the drug group withdrew because of the severity of their symptoms and 1 patient assigned to the Abl+Pm group in whom the ablation procedure failed. At the end of the 6 months, the 21 patients of the Abl+Pm group who completed the study showed, in comparison with the 18 of the drug group, lower scores in the Living with Heart Failure Questionnaire (−51%, P=.0006), palpitat...
254 citations
TL;DR: It is suggested that in obese hypertensives compared to obese normotensives, the lower NPr-A-NPr-C ratio might determine decreased biological activity and/or an increased clearance of natriuretic peptide in adipose tissue, suggesting that the natriUREtic peptides and its receptor system may be important in obesity-related hypertension where ANP levels are lower.
Abstract: Objective Human and rat adipose tissue contain very high levels of natriuretic peptides clearance receptor messenger (m)RNA, and fasting inhibits its gene expression in adipose tissue. In this study we evaluated plasma atrial natriuretic peptide (ANP) and gene expression of biologically active type A natriuretic peptide receptor (NPr-A) and clearance natriuretic peptide receptor (NPr-C) in adipose tissue of obese hypertensive and obese normotensive patients. Design and methods We studied 27 untreated obese hypertensives, 26 obese normotensives (body mass index ≥ 30 kg/m 2 ), 24 non-obese essential hypertensives and 23 lean healthy subjects (body mass index ≤ 25 kg/m 2 ). Blood samples were withdrawn for ANP, plasma renin activity and aldosterone radioimmunoassays. Subcutaneous peri-umbilical adipose tissue samples were obtained, by needle aspiration, in 13 obese hypertensives and in 12 obese normotensives and used for RNA extraction. Then, complementary synthesis and semiquantitative polymerase chain reaction (PCR) with primers complementary to sequences of different exons of the genes encoding for NPr-A, NPr-C and β-actin, were performed. 32 P-labeled PCR products were separated by electrophoresis, blotted onto nylon membranes, and the exposed autoradiographic films were analysed by densitometry. NPr signals were normalized by the β-actin expression level. Results Plasma ANP was lower in obese hypertensives than in obese normotensives (37.5 ± 7 versus 43.2 ± 6 pg/ml, P< 0.05), but was higher in non-obese hypertensives than in non-obese normotensives. In contrast, plasma renin activity and aldosterone were higher in the obese hypertensives. Although NPr-A and NPr-C expression were not statistically different between the two obese groups, the NPr-A: NPr-C mRNA ratios were significantly lower in obese hypertensives (P < 0.03). Conclusions Our data suggest that in obese hypertensives compared to obese normotensives, the lower NPr-A: NPr-C ratio might determine decreased biological activity and/or an increased clearance of natriuretic peptide in adipose tissue, suggesting that the natriuretic peptide and its receptor system may be important in obesity-related hypertension where ANP levels are lower.
197 citations
Journal Article•
TL;DR: The hypothesis that MKP-1 inhibits apoptosis in human prostate tumors, perhaps through the JNK pathway, is supported and is associated with the early phases of neoplastic transformation in prostate tissue.
173 citations
TL;DR: In patients with symptomatic SSS, therapy with theophylline or dual-chamber pacemaker is associated with a lower incidence of heart failure; pacemaker therapy is also associated with the occurrence of syncope.
Abstract: Background Pacemakers and theophylline are currently being used to relieve symptoms in patients with sick sinus syndrome (SSS). However, the impact of either therapy on the natural course of the disease is unknown. We conducted a randomized controlled trial to prospectively assess the effects of pacemakers and theophylline in patients with SSS. Methods and Results One hundred seven patients with symptomatic SSS (age, 73±11 years) were randomized to no treatment (control group, n=35), oral theophylline (n=36), or dual-chamber rate-responsive pacemaker therapy (n=36). They were followed for up to 48 months (mean, 19±14 months). During follow-up, the occurrence of syncope was lower in the pacemaker group than in the control group (P=.02) and tended to be lower than in the theophylline group (P=.07). Heart failure occurred less often in patients assigned to pacemaker therapy and theophylline than in control patients (both, P=.05), whereas the incidence of sustained paroxysmal tachyarrhythmias, permanent atria...
140 citations
TL;DR: Since secretin targets cholangiocytes during parasympathetic predominance, coordinated regulation of Cl-/HCO3- exchanger by secretin (cAMP) and ACh (Ca2+) could play a major role in the regulation of ductal bicarbonate excretion in bile just when the bICarbonate requirement in the intestine is maximal.
Abstract: We investigated, in isolated bile duct units (IBDU) and chol- angiocytes isolated from normal rat liver, the occurrence of acetylcholine (ACh) receptors, and the role and mecha- nisms of ACh in the regulation of the Cl 2 /HCO 3 2 exchanger activity. The Cl 2 /HCO 3 2 exchanger activity was evaluated measuring changes in intracellular pH induced by acute Cl 2 removal/readmission. M3 subtype ACh receptors were detected in IBDU and isolated cholangiocytes by immuno- fluorescence, immunoelectron microscopy, and reverse tran- scriptase PCR. M1 subtype ACh receptor mRNA was not detected by reverse transcriptase PCR and M2 subtype was negative by immunofluorescence. ACh (10 m M) showed no effect on the basal activity of the Cl 2 /HCO 3 2 exchanger. When IBDU were exposed to ACh plus secretin, ACh sig- nificantly ( P , 0.03) increased the maximal rate of alkalin- ization after Cl 2 removal and the maximal rate of recovery after Cl 2 readmission compared with secretin alone (50 nM), indicating that ACh potentiates the stimulatory effect of se- cretin on the Cl 2 /HCO 3 2 exchanger activity. This effect of ACh was blocked by the M3 ACh receptor antagonist, 4-diphenyl-acetoxy- N- (2-chloroethyl)-piperidine (40 nM), by the intracellular Ca 2 1 chelator, 1,2-bis (2-Aminophenoxy)- ethane-N,N,N 9 ,N 9 -tetraacetic acid acetoxymethylester (50 m M), but not by the protein kinase C antagonist, staurosporine (0.1 m M). Intracellular cAMP levels, in isolated rat cholan- giocytes, were unaffected by ACh alone, but were markedly higher after exposure to secretin plus ACh compared with secretin alone ( P , 0.01). The ACh-induced potentiation of the secretin effect on both intracellular cAMP levels and the Cl 2 /HCO 3 2 exchanger activity was individually abolished by two calcineurin inhibitors, FK-506 and cyclosporin A (100 nM). Conclusions: M3 ACh receptors are markedly and diffu- sively represented in rat cholangiocytes. ACh did not influ- ence the basal activity of the Cl 2 /HCO 3 2 exchanger, but en- hanced the stimulation by secretin of this anion exchanger by a Ca 2 1 -dependent, protein kinase C-insensitive pathway that potentiates the secretin stimulation of adenylyl cyclase. Calcineurin most likely mediates the cross-talk between the calcium and adenylyl cyclase pathways. Since secretin tar- gets cholangiocytes during parasympathetic predomi- nance, coordinated regulation of Cl 2 /HCO 3 2 exchanger by secretin (cAMP) and ACh (Ca 2 1 ) could play a major role in the regulation of ductal bicarbonate excretion in bile just when the bicarbonate requirement in the intestine is maxi- mal. ( J. Clin. Invest. 1997. 100:1349-1362.) Key words: ace- tylcholinesecretincAMPCa 2 1 • calcineurinadenylyl cyclase
130 citations
TL;DR: The results of a multicentric retrospective evaluation of patients with adrenal incidentalomas suggest that the best parameter for evaluating subclinical hypercortisolism seems to be the overnight dexamethasone suppression test.
Abstract: Adrenal masses are more and more frequently detected by adrenal ultrasound, computed tomography or nuclear magnetic resonance carried out for a reason other than the suspicion of adrenal disease (inci
125 citations
TL;DR: In this paper, the polymorphism of CCR-5 gene in HIV-1-infected and uninfected subjects was analyzed and the delta 32/delta 32 deletion was detected by PCR and sequencing confirmed in a patient with progressive infection harboring a clade B virus with SI phenotype.
Abstract: Background Recent research has found that entry of non-syncytium-inducing (NSI), monocyte-macrophage-tropic HIV-1 isolates requires binding to both CD4 and CCR5 receptors, and that delta 32/delta 32 homozygous individuals are protected against infection. Objective To analyse the polymorphism of CCR-5 gene in HIV-1-infected and uninfected subjects. Design and methods CCR-5 sequences were amplified by polymerase chain reaction (PCR) from DNA of peripheral blood mononuclear cells. Samples from 152 HIV-1-infected subjects and 122 uninfected controls were tested for the detection of the 32 base-pair deletion. HIV-1 phenotype was determined by viral isolation and MT-2 evaluation. Results The wild-type/delta 32 heterozygous and delta 32/delta 32 homozygous conditions were represented in 10.7 and 0.8% of healthy controls and in 9.8 and 0.7% of HIV-1-infected subjects, respectively. Of note, the delta 32/delta 32 deletion of the CCR-5 gene was detected by PCR and sequencing confirmed in a patient with progressive infection harbouring a clade B virus with SI phenotype. Conclusions delta 32/delta 32 homozygosity for the CCR-5 gene does not confer absolute protection against HIV-1 infection, suggesting that either macrophage-tropic viral strains could use coreceptors other than CCR-5 or infect independently of the presence of a functional CCR-5 coreceptor. Alternatively, primary infection sustained by T-cell-tropic isolates, although exceptional, may occur.
123 citations
TL;DR: The results suggest the usefulness of antiplatelet agents in the treatment of acute phase TTP patients and one-year ticlopidine maintenance therapy appears to be beneficial in preventing TTP relapses; however, only the completion of an adequate follow-up for all patients will definitively confirm this observation.
Abstract: BACKGROUND AND OBJECTIVE: Antiplatelet agents are often included in plasma exchange-based regimens for thrombotic thrombocytopenic purpura (TTP) patients; however, the opportuneness of their use in TTP is still controversial. The italian Cooperative Group for TTP carried out a randomized trial to investigate their actual effectiveness, both in acute TTP and as maintenance treatment. METHODS: Seventy-two TTP patients were randomized to receive plasma exchange and steroids with (group B) or without (group A) aspirin and dipyridamole. Treatment efficacy was evaluated after 15 days and salvage treatments were also considered for non-responders. Upon disease remission, the patients already treated with antiplatelet agents received ticlopidine for one year. RESULTS: Regarding the treatment of acute phase TTP, similar overall response rates were observed in the two groups (91.4% in group B vs. 75.6% in group A), but lower mortality rates were observed at 15 days in the patients treated with antiplatelet agents; as a matter of fact, 5 patients from arm A died in the first 15 days (13.5%) versus only one in arm B (2.8%). These figures, while not statistically significant, seem to suggest that antiplatelet agents might be useful in preventing deaths in acute TTP; moreover, bleeding did not worsen in antiplatelet agent-treated patients. As for the role of maintenance treatment, our results support the efficacy and safety of one-year ticlopidine therapy since the current relapse rate is significantly higher in non-treated patients; as a matter of fact, 6 patients (21.4%) in the non-ticlopidine group and only 2 (6.25%) in the ticlopidine group relapsed (P = .0182 in favor of maintenance treatment). INTERPRETATION AND CONCLUSIONS: Our results suggest the usefulness of antiplatelet agents in the treatment of acute phase TTP patients. Moreover, one-year ticlopidine maintenance therapy appears to be beneficial in preventing TTP relapses; however, only the completion of an adequate follow-up for all patients will definitively confirm this observation.
121 citations
TL;DR: The risk of sexual transmission of hepatitis C and the value of prophylaxis with periodic intramuscular immune serum globulin administration are estimated and hyperimmune anti-HCV immune serum Globulin should be prepared from blood testing positive for antibodies to HCV, which is currently discarded.
Abstract: Objectives: To estimate the risk of sexual transmission of hepatitis C and to assess the value of prophylaxis with periodic intramuscular immune serum globulin administration. Methods: Of 1102 steady heterosexual partners of patients with antibodies to the hepatitis C virus (HCV), 899 were enrolled in a single-blind, randomized, controlled trial. All the partners tested negative for antibodies to HCV and had normal baseline serum aminotransferase concentrations. The partners were assigned to receive 4 mL of 16% polyvalent immune serum globulin prepared from unscreened donors every 2 months (n=450) or a placebo (n=449). Tests for HCV infection were performed every 4 months. Results: Eight hundred eighty-four partners completed the study. Seven partners became infected with HCV: 6 in the control group (incidence density, 12.00 per 1000 person-years; 95% confidence interval, 3.0-21.61) and 1 in the immune serum globulin group (incidence density, 1.98 per 1000 person-years; 95% confidence interval, 0-5.86). The risk of infection was significantly higher for partners in the control group ( P =.03): for each year approximately 1% of the partners became infected. Sequence homology studies strongly suggest the sexual transmission of HCV. All immune serum globulin lots used had high enzyme-linked immunosorbent assay titers of neutralizing antibodies to HCV envelope glycoproteins and high neutralization titers in the neutralization of binding assay. Conclusions: Hepatitis C can be sexually transmitted. Immune serum globulin prepared from unscreened donors significantly reduced the risk. The treatment was safe and well tolerated. Because only immune serum globulin from unscreened donors (and not from those screened for HCV) contain anti-HCV neutralizing antibodies, hyperimmune anti-HCV immune serum globulin should be prepared from blood testing positive for antibodies to HCV, which is currently discarded. Arch Intern Med. 1997;157:1537-1544
118 citations
Journal Article•
TL;DR: Italian patients with primary SS have increased risk of developing NHL and the absence of a significant difference between the north and the centre-south of Italy contrasts with the higher incidence of NHL in the general population of northern regions and strengthens the direct connection between primary SS and NHL.
Abstract: Objective. To assess the incidence of non-Hodgkin's lymphoma (NHL) and estimate the relative risk (RR) of developing lymphoproliterative complications in a large population of Italian patients with Sjogren's syndrome (SS) and to ascertain if any difference exists between the north and centre-south of Italy. Methods. Differential relative risks of NHL were obtained by comparing the number of observed cases with cases identified on the basis of age-sex-time specific incidence rates extracted from regional cancer registries. Results. Among the 331 patients with SS studied, 9 cases of NHL occurred, while no lymphoid malignancy appeared in patients with overlapping connective tissue disease (secondary SS) or in males with primary SS. As the number of NHL cases identified on the basis of the rate in the cancer registries would have been 0.27, the RR is 33.3 (p < 0.001). The incidence rate of NHL in Italian patients with SS is about 5.1/1000 person-years. 5.4/1000 per year in the north of the country and 4.8/1000 per year in the centre-south. The relative risks are, respectively, 34.7 and 32.5. Conclusion. Italian patients with primary SS have increased risk of developing NHL. In this group, the absence of a significant difference between the north and the centre-south of Italy contrasts with the higher incidence of NHL in the general population of northern regions and strengthens the direct connection between primary SS and NHL.
102 citations
TL;DR: The findings indicate that M. celatum may cause serious disease in patients with advanced human immunodeficiency virus-related immunosuppression and appears to be responsive to antimycobacterial chemotherapy; however, further studies are needed to establish the optimal drug combination for this indication.
Abstract: Mycobacterium celatum is a recently described, slowly growing mycobacterium of still undefined clinical relevance A retrospective study of seven patients was conducted to further elucidate the clinical presentation and prognosis of infection due to M celatum in patients with AIDS Three patients had an exclusively pulmonary infection and 3 had disseminated infection (including 2 patients with pulmonary and extrapulmonary involvement), and 1 patient had an exclusively extrapulmonary disease Fever, weight loss, and productive cough lasting for >2 weeks were the most common symptoms Chest radiographs showed diffuse or focal interstitial infiltrates without cavitation The recovery of M celatum from one patient was definitively determined to be clinically irrelevant Our findings indicate that M celatum may cause serious disease in patients with advanced human immunodeficiency virus-related immunosuppression M celatum infection appears to be responsive to antimycobacterial chemotherapy; however, further studies are needed to establish the optimal drug combination for this indication
TL;DR: In type 1 diabetic patients, the platelet membrane responds to activation with a molecular remodeling different from the response of healthy subjects, and acute exposure to high glucose levels does not seem able to modify the Platelet membrane in the way observed in type 1 diabetes.
Abstract: A modified platelet response to aggregating stimuli is supposed to play a role in the pathogenesis of diabetic macroangiopathy. We studied the fluidity and microheterogeneity of the external surface of the platelet membrane and the activities of the plasma membrane Na+-K+-ATPase and Ca2+-ATPase in 21 men with type 1 diabetes and in 20 control subjects before and after in vitro thrombin addition. In the resting state, platelets from type 1 diabetic patients showed an increased fluidity and microheterogeneity of the platelet membrane, a higher Ca2+-ATPase activity, and a reduced Na+-K+-ATPase activity in comparison with platelets from healthy subjects. The fatty acid composition was also modified, with increased C 16:1 and decreased C 18:0 content. Control cells incubated with thrombin showed a modification of the membrane parameters opposite to the response observed in type 1 cells after the stimulation. The incubation of control platelets in the resting state with high concentrations of glucose modified the fluidity of the plasma membrane Na+-K+-ATPase and Ca2+-ATPase activities in an opposite way in comparison with the alterations observed in type 1 platelets. This study suggests that in type 1 diabetic patients, the platelet membrane responds to activation with a molecular remodeling different from the response of healthy subjects. The abnormal organization of the membrane might contribute to the altered platelet functions in type 1 diabetic patients, but acute exposure to high glucose levels does not seem able to modify the platelet membrane in the way observed in type 1 diabetes.
TL;DR: The cytogenetic data indicate that heterochromatin in these taxa is highly differentiated, exhibiting heterogeneity in staining characteristics, and presumably in underlying DNA sequences, and a different capability for promoting Robertsonian fusions.
Abstract: A karyological study of four species of gobiid fishes, Gobius niger, G. paganellus, G. cobitis, and Zosterisessor ophiocephalus (Perciformes, Gobiidae), was conducted by standard, fluorochrome staining (using chromomycin A3, mithramycin, and DAPI), Alu-I digestion, and CBG- and RBG-banding methods. Our cytogenetic data indicate that heterochromatin in these taxa is highly differentiated, exhibiting heterogeneity in staining characteristics, and presumably in underlying DNA sequences, and a different capability for promoting Robertsonian fusions.
TL;DR: Close biological and molecular similarities between RIs and LTNPs on the one hand, and LPs and TPs onThe other are demonstrated.
Abstract: Human immunodeficiency virus type 1 (HIV-1) isolability, rate of replication, phenotype, plasma viremia, and specific intracellular transcripts were cross-sectionally analyzed in 61 HIV-1-seroposit...
TL;DR: A newborn girl is described with an association of spondylo-acrodysplasia, mild short limbed dwarfism without significant metaphyseal changes, joint dislocations, and severe immune system dysfunction.
Abstract: A newborn girl is described with an association of spondylo-acrodysplasia, mild short limbed dwarfism without significant metaphyseal changes, joint dislocations, and severe immune system dysfunction. This association is distinct from other known immuno-osseous dysplasias, including Schimke dysplasia, ADA deficiency with osseous changes, and Omenn phenotype with short limbed dwarfism.
TL;DR: In this paper, the role of uncertainty on investment in the Italian economy was analyzed and it was shown that, theoretically, and in the presence of irreversibility, demand and interest rate uncertainty both reduce demand for capital.
Abstract: This paper aims at analyzing the role of uncertainty on investment. In our analysis we will follow recent economic literature concerning stochastic models of irreversible investment and restrict our attention to the Italian economy. We show that theoretically, and in the presence of irreversibility, demand and interest rate uncertainty both reduce demand for capital. Our empirical results support the traditional interpretation according to which expected demand growth rates positively affect investment, while the interest rate level is negatively correlated to the accumulation rate. As for uncertainty, investment decisions in Italy are negatively affected by demand volatility, while interest rate volatility seems to play no significant role.
TL;DR: Evaluated toxicity and response of the combined administration of recombinant interferon α (IFNα) and low-dose subcutaneous (s.c.) recombinant IL-2 in patients with advanced renal cell carcinoma seem to indicate an effectiveness comparable to, and a toxicity lower than, that of regimens employing higher doses ofIL-2.
Abstract: The activity of the drugs employed in the treatment of metastatic renal cell carcinoma, including biological response modifiers, is limited; one of the aims of clinical research in this area is to maintain the benefits of treatment whilst reducing its toxicity to a minimum level. We have evaluated toxicity and response of the combined administration of recombinant interferon α (IFNα) and low-dose subcutaneous (s.c.) recombinant interleukin-2 (IL-2) in patients with advanced renal cell carcinoma. A group of 20 previously untreated patients with advanced renal cell carcinoma were included in the study. Treatment consisted of 3 MU/m2 recombinant IFNα daily i.m. continuously, and 0.5 MU/m2 recombinant IL-2 twice a day s.c. on days 1–5 for the first week, followed by 1 MU/m2 twice a day for 5 days in the following weeks. For IL-2, a 1-week rest was allowed after 4 weeks of treatment. Response was assessed after 3 months of therapy. Three objective responses were seen, one complete and two partial. Eight patients had stable disease. The median time to progression was 6 months; the median survival for all patients was 14 months. Side-effects were low, limited to grades 1 and 2 in the majority of patients, and included fever, anemia, leukopenia, dyspnea, and abnormalities of liver and renal function tests. Any flu-like syndrome was judged moderate in most patients; however, one-third of the patients refused treatment mostly because of the flu-like syndrome. One of these was the patient experiencing a complete response, who virtually received IFNα alone. This regimen, similar to others employed in the treatment of advanced renal cell carcinoma, produced a 15% response rate (95% confidence interval, 0–31%) with 14 months median survival, moderate toxicity and low cost, and required no hospitalization. These data seem to indicate an effectiveness comparable to, and a toxicity lower than, that of regimens employing higher doses of IL-2.
TL;DR: In the experimental model, VP-16 did not show improved efficacy over ASTA-Z in killing leukemic cells and in sparing normal progenitors, and the efficacy of etoposide with that of mafosfamide, which has been used mainly for purging in acute leukemias.
Abstract: Residual leukemic cells in a bone marrow graft may increase the risk of relapse after autotransplantation. We have compared the efficacy of etoposide with that of mafosfamide, which has been used mainly for purging in acute leukemias. First, we examined the effects of VP-16 and ASTA-Z on the normal hematopoietic progenitors and on the erythroleukemic cell K562. Subsequently, we evaluated purging activity in cocultures using two different ratios of leukemic contamination. The most effective drug concentrations in inhibiting 100% of K562 growth were 50 micrograms/ml of ASTA-Z and 70 micrograms of VP-16. Residual growth of normal colony-forming units-granulocyte-macrophage (CFU-GM) was 4.8% with VP-16 and 32.5% with ASTA-Z. In treated cocultures, ASTA-Z produced a higher inhibition of the K562 line than VP-16 at both levels of leukemic cell contamination. At 0.5% contamination, VP-16 showed higher toxicity toward normal hematopoietic progenitors than ASTA-Z. At the 5% contamination level, VP-16 completely inhibited colony formation, whereas ASTA-Z spared some normal progenitor cells (21.2%). In conclusion, in our experimental model, VP-16 did not show improved efficacy over ASTA-Z in killing leukemic cells and in sparing normal progenitors.
TL;DR: The technique seems to be suitable for routine determination of the three analytes, especially for mass screening purposes, and in comparisons with Radjaipur's extraction method the slopes for the three analyzetes were nearly 1, and the confidence region of the intercepts was close to 0.
Abstract: Summary: A new isocratic HPLC method, employing electrochemical detection, is described for the determination of urinary vanillylmandelic acid, 5-hydroxyindoleacetic acid and homovanillic acid. The main advantages of this technique are: simplicity, simultaneous determination of all analytes, the absence of an extraction procedure, isocratic elution and low cost. The diluted urine is injected onto a CIS reversed phase column. The mobile phase is potassium dihydrogenphosphate buffer containing 1heptanesulphonic acid, methanol and acetonitrile. The calibration curves are linear from 0.1 to 50 mg/1; the precision data show CV less than 2.36% for within-day assay and less than 2.72% for day-to-day assays. The mean recoveries for supplemented samples are 98.2 to 102.0% for vanillylmandelic acid, 99.6 to 103.9% for 5-hydroxyindoleacetic acid and 98.7 to 102.0% for homovanillic acid. In comparisons of the present method with Radjaipur's extraction method (Radjaipur M. et al., Eur J Clin Chem Clin Biochem 1994; 32:609-13) the slopes for the three analytes were nearly 1, and the confidence region of the intercepts was close to 0. In conclusion the technique seems to be suitable for routine determination of the three analytes, especially for mass screening purposes.
27 Aug 1997
TL;DR: In this paper, numerical simulations are performed aimed at checking the effectiveness of a previously developed theoretical procedure for control of transient chaos in reducing also the steady-state chaotic dynamics of an impact mechanical system.
Abstract: Numerical simulations are performed aimed at checking the effectiveness of a previously developed theoretical procedure for control of transient chaos in reducing also the steady-state chaotic dynamics of an impact mechanical system. Attractor-basin phase portraits and bifurcation diagrams are built to show good agreement between the theoretical predictions and the actual response of the system.
Journal Article•
Journal Article•
Journal Article•
TL;DR: 1 U.R.CA Ancona ltaly 2 Istituto di Istologia ed Embriologia Generale Università degli Studi di Bologna lTaly 3 U.N.O. di Dermatologia e Chirurgia Plastica and 4 U.M.C.A.
Abstract: M.G. Tucci', C. Zucchini>, G. Ricotti', A. Fionda', L MorresP, S. Serresi', A. De Benedittis', G. Biagini' ' Dipartimento Ricerche, l.N.R.CA Ancona ltaly 2 Istituto di Istologia ed Embriologia Generale Università degli Studi di Bologna ltaly 3 U.O. di Dermatologia e Chirurgia Plastica, l.N.R.CA Ancona ltaly • Research and development MAVI sud Aprilia Latina ltaly ' Istituto di Morfologia Umana Normale, Università degli Studi di Ancona ltaly