Marche Polytechnic University

About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.

Influence of cooking conditions on cooking loss and tenderness of raw and marinated chicken breast meat

Abstract: The influence of different cooking treatments on tenderness and cooking loss, as main quality characteristics of chicken breast meat, was investigated Industrial skinless chicken breast meat samples were designated as raw and marinated and cooked in the oven by hot air and hot air-steam mixture at 130, 150 and 170 °C, for 4, 8 and 12 min Cooking losses were evaluated by weight changes before and after cooking, and tenderness changes were determined on cooked samples by measuring shear force using instrumental texture analysis Results showed that marination, followed by air-steam cooking is the best combination to obtain the most tender chicken breast slices The time and temperature of cooking showed similar effects on cooking loss and tenderness: short cooking time (4 min) and temperatures of 130–150 °C resulted in lower cooking losses and best meat tenderness, in both not marinated and marinated meat Statistically significant correlations between tenderness and cooking loss indicated that the cooking loss correlated better with cooking time than with cooking temperature An opposite phenomenon was observed for meat tenderness

Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions

Abstract: We investigated, in isolated bile duct units (IBDU) and chol- angiocytes isolated from normal rat liver, the occurrence of acetylcholine (ACh) receptors, and the role and mecha- nisms of ACh in the regulation of the Cl 2 /HCO 3 2 exchanger activity. The Cl 2 /HCO 3 2 exchanger activity was evaluated measuring changes in intracellular pH induced by acute Cl 2 removal/readmission. M3 subtype ACh receptors were detected in IBDU and isolated cholangiocytes by immuno- fluorescence, immunoelectron microscopy, and reverse tran- scriptase PCR. M1 subtype ACh receptor mRNA was not detected by reverse transcriptase PCR and M2 subtype was negative by immunofluorescence. ACh (10 m M) showed no effect on the basal activity of the Cl 2 /HCO 3 2 exchanger. When IBDU were exposed to ACh plus secretin, ACh sig- nificantly ( P , 0.03) increased the maximal rate of alkalin- ization after Cl 2 removal and the maximal rate of recovery after Cl 2 readmission compared with secretin alone (50 nM), indicating that ACh potentiates the stimulatory effect of se- cretin on the Cl 2 /HCO 3 2 exchanger activity. This effect of ACh was blocked by the M3 ACh receptor antagonist, 4-diphenyl-acetoxy- N- (2-chloroethyl)-piperidine (40 nM), by the intracellular Ca 2 1 chelator, 1,2-bis (2-Aminophenoxy)- ethane-N,N,N 9 ,N 9 -tetraacetic acid acetoxymethylester (50 m M), but not by the protein kinase C antagonist, staurosporine (0.1 m M). Intracellular cAMP levels, in isolated rat cholan- giocytes, were unaffected by ACh alone, but were markedly higher after exposure to secretin plus ACh compared with secretin alone ( P , 0.01). The ACh-induced potentiation of the secretin effect on both intracellular cAMP levels and the Cl 2 /HCO 3 2 exchanger activity was individually abolished by two calcineurin inhibitors, FK-506 and cyclosporin A (100 nM). Conclusions: M3 ACh receptors are markedly and diffu- sively represented in rat cholangiocytes. ACh did not influ- ence the basal activity of the Cl 2 /HCO 3 2 exchanger, but en- hanced the stimulation by secretin of this anion exchanger by a Ca 2 1 -dependent, protein kinase C-insensitive pathway that potentiates the secretin stimulation of adenylyl cyclase. Calcineurin most likely mediates the cross-talk between the calcium and adenylyl cyclase pathways. Since secretin tar- gets cholangiocytes during parasympathetic predomi- nance, coordinated regulation of Cl 2 /HCO 3 2 exchanger by secretin (cAMP) and ACh (Ca 2 1 ) could play a major role in the regulation of ductal bicarbonate excretion in bile just when the bicarbonate requirement in the intestine is maxi- mal. ( J. Clin. Invest. 1997. 100:1349-1362.) Key words: ace- tylcholinesecretincAMPCa 2 1 • calcineurinadenylyl cyclase

The US Wage Phillips Curve across Frequencies and over Time

Abstract: Although widely used in many areas of applied sciences, wavelet analysis has not fully entered the economic discipline yet. In this article we apply wavelet analysis to one of the most investigated relationships is in empirical macroeconomics: the relationship between wage inflation and unemployment. Using US postwar data we find a frequency-dependent relationship of a sort that is consistent with Phillips’ original insights. It also turns out that this relationship is remarkably stable over the 1948–93 period, but not in the aftermath, as a consequence of a process of adaption of the wage formation process to a low inflation environment.

A novel formulation for blood trauma prediction by a modified power-law mathematical model

Abstract: With the increasing use of artificial organs, blood damage has been raising ever more clinical concern. Blood trauma is in fact a major complication resulting from the implantation of medical devices and the use of life support apparatuses. Red blood cells damage predictive models furnish critical information on both the design and the evaluation of artificial organs, because their correct usage and implementation are thought to provide clear and rational guidance for the improvement of safety and efficacy. The currently adopted power-law shear-induced haemolysis prediction model lacks sensitivity with respect to the cumulative effect of previously applied stress magnitudes. An alternative model is proposed where a mechanical quantity was defined, able to describe the blood damage sustained by red cells under unsteady stress conditions, taking into account the load history. The proposed formulation predicted the same trend as the available experimental data. The obtained results have to be considered a preliminary validation of the basic hypothesis of this modified red blood cell damage prediction model. To date, the necessity to design further experiments to validate the proposed damage function clashes with the limitations inherent to current systems to get the time-varying shear stress completely under control.