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Institution

Marche Polytechnic University

EducationAncona, Italy
About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Prostate cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.


Papers
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Journal ArticleDOI
TL;DR: The data suggest that the occurrence of VTE may be associated with a reduced response rate and a shorter PFS and OS among patients with irresectable pancreatic cancer.

123 citations

Journal ArticleDOI
TL;DR: In this paper, the authors compared two building heat consumption models for urban scale applications: a statistical model based on 2D-GIS and multiple linear regression, and an engineering model making use of 3D city models and monthly energy balance of standard EN ISO 13790.

123 citations

Journal ArticleDOI
16 Nov 2010-PLOS ONE
TL;DR: Robust expression of α-SMA and type-I collagen, high and uniformly-distributed ROS levels, resistance to oxidative-stress induced cell death and constitutive activation of tyrosine kinase(s) signalling are distinctive features of the IPF phenotype.
Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal illness whose pathogenesis remains poorly understood. Recent evidence suggests oxidative stress as a key player in the establishment/progression of lung fibrosis in animal models and possibly in human IPF. The aim of the present study was to characterize the cellular phenotype of fibroblasts derived from IPF patients and identify underlying molecular mechanisms. Methodology/Principal Findings: We first analyzed the baseline differentiation features and growth ability of primary lung fibroblasts derived from 7 histology proven IPF patients and 4 control subjects at different culture passages. Then, we focused on the redox state and related molecular pathways of IPF fibroblasts and investigated the impact of oxidative stress in the establishment of the IPF phenotype. IPF fibroblasts were differentiated into alpha-smooth muscle actin (SMA)-positive myofibroblasts, displayed a pro-fibrotic phenotype as expressing type-I collagen, and proliferated lower than controls cells. The IPF phenotype was inducible upon oxidative stress in control cells and was sensitive to ROS scavenging. IPF fibroblasts also contained large excess of reactive oxygen species (ROS) due to the activation of an NADPH oxidase-like system, displayed higher levels of tyrosine phosphorylated proteins and were more resistant to oxidative-stress induced cell death. Interestingly, the IPF traits disappeared with time in culture, indicating a transient effect of the initial trigger. Conclusions/Significance: Robust expression of a-SMA and type-I collagen, high and uniformly-distributed ROS levels, resistance to oxidative-stress induced cell death and constitutive activation of tyrosine kinase(s) signalling are distinctive features of the IPF phenotype. We suggest that this phenotype can be used as a model to identify the initial trigger of IPF.

123 citations

Journal ArticleDOI
TL;DR: A research strategy based on descriptive statistics, kernel density estimation, concentration and Markov stationarity methods is proposed in order to analyze the dynamics of overall specialization.
Abstract: It is customary in the empirical trade literature to analyze specialization patterns of countries using Revealed Comparative Advantage (RCA) measures. This paper explores the informational content of the most commonly used RCA index: the Balassa (1965) Index of RCA. After describing the properties of the Balassa Index, we propose a research strategy based on descriptive statistics, kernel density estimation, concentration and Markov stationarity methods in order to analyze the dynamics of overall specialization.

123 citations

Journal ArticleDOI
01 Aug 1997-AIDS
TL;DR: In this paper, the polymorphism of CCR-5 gene in HIV-1-infected and uninfected subjects was analyzed and the delta 32/delta 32 deletion was detected by PCR and sequencing confirmed in a patient with progressive infection harboring a clade B virus with SI phenotype.
Abstract: Background Recent research has found that entry of non-syncytium-inducing (NSI), monocyte-macrophage-tropic HIV-1 isolates requires binding to both CD4 and CCR5 receptors, and that delta 32/delta 32 homozygous individuals are protected against infection. Objective To analyse the polymorphism of CCR-5 gene in HIV-1-infected and uninfected subjects. Design and methods CCR-5 sequences were amplified by polymerase chain reaction (PCR) from DNA of peripheral blood mononuclear cells. Samples from 152 HIV-1-infected subjects and 122 uninfected controls were tested for the detection of the 32 base-pair deletion. HIV-1 phenotype was determined by viral isolation and MT-2 evaluation. Results The wild-type/delta 32 heterozygous and delta 32/delta 32 homozygous conditions were represented in 10.7 and 0.8% of healthy controls and in 9.8 and 0.7% of HIV-1-infected subjects, respectively. Of note, the delta 32/delta 32 deletion of the CCR-5 gene was detected by PCR and sequencing confirmed in a patient with progressive infection harbouring a clade B virus with SI phenotype. Conclusions delta 32/delta 32 homozygosity for the CCR-5 gene does not confer absolute protection against HIV-1 infection, suggesting that either macrophage-tropic viral strains could use coreceptors other than CCR-5 or infect independently of the presence of a functional CCR-5 coreceptor. Alternatively, primary infection sustained by T-cell-tropic isolates, although exceptional, may occur.

123 citations


Authors

Showing all 6013 results

NameH-indexPapersCitations
Jonathan I. Epstein138112180975
Antoni Ribas13266099227
Francesco Fiori128103276699
Claudio Franceschi12085659868
Robert E. Coleman10372449796
Carmine Zoccali9981336774
Massimo Falconi9466741966
Mario Plebani91132943055
Roberto Danovaro8441523735
Rodolfo Montironi8395830957
Diego Centonze8146322857
Saverio Cinti7825632760
Michele Brignole7639926758
Jürgen P. Rabe7639120174
Jean-Jacques Body7038419608
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202376
2022181
20211,353
20201,390
20191,289
20181,148