Marche Polytechnic University

About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Prostate cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.

Clinical aspects of coenzyme Q10: an update.

Abstract: Purpose of review Coenzyme Q 1 0 is administered for an ever-widening range of disorders, therefore it is timely to illustrate the latest findings with special emphasis on areas in which this therapeutic approach is completely new. These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q 1 0 . Rencent findings Cardiovascular properties of coensyme Q 1 0 have been further addressed, namely regarding myocardial protection during cardiac surgery, end-stage heart failure, pediatric cardiomyopathy and in cardiopulmonary resuscitation. The vascular aspects of coenzyme Q 1 0 addressing the importance field on endothelial function are briefly examined. The controversial issue of the statin/coenzyme Q 1 0 relationship has been investigated in preliminary studies in which the two substances were adminstered simultaneously. Work on different neurological diseases, involving mitochondrial dysfunction and oxidative stress, highlights some of the neuroprotective mechanisms of coenzyme Q 1 0 . A 4-year follow-up on 10 Friedriech's Ataxia patients treated with coenzyme Q 1 0 and vitamin E showed a substantial improvement in cardiac and skeletal muscle bioenergetics and heart function. Mitochondrial dysfunction likely plays a role in the pathophysiology of migraine as well as age-related macular degeneration and a therapy including coenzyme Q 1 0 produced significant improvement. Finally, the effect of coenzyme Q 1 0 was evaluated in the treatment of asthenozoospermia. Summary The latest findings highlight the beneficial role of coenzyme Q 1 0 as coadjuvant in the treatment of syndromes, characterized by impaired mitochondrial bioenergetics and increased oxidative stress, which have a high social impact. Besides their clinical significance, these data give futher insight into the biochemical mechanisms of coenzyme Q 1 0 activity.