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Institution

Marche Polytechnic University

EducationAncona, Italy
About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Prostate cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.


Papers
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Journal ArticleDOI
TL;DR: In an analysis of data from individual patients with PSC worldwide, significant variation in clinical course associated with age at diagnosis, sex, and ductal and IBD subtypes is found.

334 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigated the performance of green roofs in terms of their expected benefits for the building and the urban environment, due to their recognised energy and water management potential scores.

333 citations

Journal ArticleDOI
TL;DR: In a methotrexate-naive population with early RA and poor prognostic factors, the combination of abatacept and methotRexate provided significantly better clinical and radiographic efficacy compared with methot Rexate alone and had a comparable, favourable safety profile.
Abstract: Objectives: To assess the efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis (RA) and poor prognostic factors. Methods: In this double-blind, phase IIIb study, patients with RA for 2 years or less were randomly assigned 1 : 1 to receive abatacept (similar to 10 mg/kg) plus methotrexate, or placebo plus methotrexate. Patients were methotrexate-naive and seropositive for rheumatoid factor (RF), anti-cyclic citrullinated protein (CCP) type 2 or both and had radiographic evidence of joint erosions. The co-primary endpoints were the proportion of patients achieving disease activity score in 28 joints (DAS28)-defined remission (C-reactive protein) and joint damage progression (Genant-modified Sharp total score; TS) at year 1. Safety was monitored throughout. Results: At baseline, patients had a mean DAS28 of 6.3, a mean TS of 7.1 and mean disease duration of 6.5 months; 96.5% and 89.0% of patients were RF or anti-CCP2 seropositive, respectively. At year 1, a significantly greater proportion of abatacept plus methotrexate-treated patients achieved remission (41.4% vs 23.3%; p<0.001) and there was significantly less radiographic progression (mean change in TS 0.63 vs 1.06; p = 0.040) versus methotrexate alone. Over 1 year, the frequency of adverse events (84.8% vs 83.4%), serious adverse events (7.8% vs 7.9%), serious infections (2.0% vs 2.0%), autoimmune disorders (2.3% vs 2.0%) and malignancies (0.4% vs 0%) was comparable for abatacept plus methotrexate versus methotrexate alone. Conclusions: In a methotrexate-naive population with early RA and poor prognostic factors, the combination of abatacept and methotrexate provided significantly better clinical and radiographic efficacy compared with methotrexate alone and had a comparable, favourable safety profile.

331 citations

Journal ArticleDOI
TL;DR: In this article, the authors analyzed heat pumps with radiators or underfloor heating distribution systems coupled with thermal energy storage (TES) with a view to showing how a heat pump system behaves and how it influences the building occupants' thermal comfort under a DSM strategy designed to flatten the shape of the electricity load curve by switching off the heat pump during peak hours.

329 citations

Journal ArticleDOI
TL;DR: GATs may play a role in the complex processes regulating cortical maturation and contribute to the dysregulation of neuronal excitability that accompanies at least two major human diseases: epilepsy and ischemia.

328 citations


Authors

Showing all 6013 results

NameH-indexPapersCitations
Jonathan I. Epstein138112180975
Antoni Ribas13266099227
Francesco Fiori128103276699
Claudio Franceschi12085659868
Robert E. Coleman10372449796
Carmine Zoccali9981336774
Massimo Falconi9466741966
Mario Plebani91132943055
Roberto Danovaro8441523735
Rodolfo Montironi8395830957
Diego Centonze8146322857
Saverio Cinti7825632760
Michele Brignole7639926758
Jürgen P. Rabe7639120174
Jean-Jacques Body7038419608
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202376
2022181
20211,353
20201,390
20191,289
20181,148