Institution
Marche Polytechnic University
Education•Ancona, Italy•
About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Prostate cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.
Topics: Population, Prostate cancer, Cancer, Mediterranean sea, Electromagnetic reverberation chamber
Papers published on a yearly basis
Papers
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Baylor College of Medicine1, Ljubljana University Medical Centre2, Necker-Enfants Malades Hospital3, University of Amsterdam4, Shanghai Jiao Tong University5, Ludwig Maximilian University of Munich6, University of Zurich7, Charles University in Prague8, University of Granada9, Marche Polytechnic University10, University of Nantes11, University of Pécs12, Umeå University13, Newcastle University14, University College London15, University of Tübingen16, University of Zagreb17, Boston Children's Hospital18, Katholieke Universiteit Leuven19, University of Ulm20, Shaare Zedek Medical Center21, University of Copenhagen22, University of Oslo23, Claude Bernard University Lyon 124, Leeds Teaching Hospitals NHS Trust25, Technion – Israel Institute of Technology26, Autonomous University of Madrid27, University of Liège28
TL;DR: ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids Alexandre Lapillonne a, b, , Nata sa Fidler Mis, Olivier Goulet, Chris H.P. van den Akker, Jennifer Wu, Berthold Koletzko.
147 citations
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TL;DR: It is suggested that miRNAs may have an important role in regulating the evolution of atherosclerotic plaque toward instability and rupture and by identifying the specific miRNA signature for stroke now, the authors are able to use computer algorithms to identify previously unrecognized molecular targets.
Abstract: Background and Purpose—Atherosclerotic plaque rupture is considered the most important mechanism that underlies the onset of stroke, myocardial infarction, and sudden death. Several evidences demonstrated the pivotal role of inflammatory processes in plaque destabilization. MicroRNAs (miRNAs) are small endogenous RNAs and represent a new important class of gene regulators. Nevertheless, no data exist about the expression profile of miRNAs in atherosclerotic plaques. Thus, the aim of this study was to investigate the expression level of miRNAs in human plaques and to correlate it with clinical features of plaque destabilization. Methods—Two separate groups of plaques were collected from patients who underwent carotid endarterectomy in Chieti (n=15) and Ancona (n=38) Hospitals. All the plaques were subdivided in symptomatic (n=22) and asymptomatic (n=31) according to the presence/absence of stroke. Results—First, on the plaques collected at Chieti Hospital, we performed large-scale analysis of miRNA express...
147 citations
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TL;DR: The aim of this study was to analyse some virulence factors of K. pneumoniae isolates, and to evaluate possible correlations between their antibiotic resistance profile and ability to form biofilm.
Abstract: Aims
Multi-drug resistant Klebsiella pneumoniae has become a relevant healthcare-associated pathogen. Capsule, type 1 and 3 fimbriae (mrkA gene), type 2 quorum-sensing system (luxS), synthesis of D-galactan I (wbbM), LPS transport (wzm) and poly-beta-1,6-N-acetyl-D-glucosamine (pgaA) seem involved in K. pneumoniae biofilm. Non-enzymatic antibiotic resistance is related to non-expression or mutation of porins (OmpK35 and OmpK36), and efflux pump (acrB) over-expression. The aim of this study was to analyse some virulence factors of K. pneumoniae isolates, and to evaluate possible correlations between their antibiotic resistance profile and ability to form biofilm.
Methods and Results
Quantitative biofilm production assay, congo red agar test and string test were performed on 120 isolates clustered in 56 extensively drug resistant (XDR, 40 MDR and 24 susceptible (S)). Nine representative strains were analyzed by real-time RT-PCR for the expression of antibiotic resistance (OmpK35, OmpK36, acrB) and biofilm production genes (mrkA, luxS,, pga, wbbM, wzm) during planktonic and sessile growth. XDR isolates showed a higher ability to form biofilm (91.07%) and to produce polysaccharides (78.57%) when compared to MDR and S strains. In biofilm-growing XDR strains, 7 out of 8 genes were upregulated, with the only exception of OmpK36.
Conclusions
XDR strains exhibited phenotypic and genotypic features supporting a significant growth as biofilm.
Significance and Impact of Study
this study produces new findings that highlight a positive correlation between antibiotic resistance profile and biofilm-forming ability in XDR K. pneumoniae strains. These new evidences might contribute to the progress in selection of therapeutic treatments of infections caused by Klebsiella pneumoniae resistant also to the “last line of defense” antibiotics, i.e. carbapenems.
This article is protected by copyright. All rights reserved.
146 citations
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TL;DR: A Mixed Integer Linear Programming formulation of the problem is proposed assuming that the battery recharging level reached at each station is a decision variable in order to guarantee more flexible routes and a Variable Neighborhood Search Branching is designed for solving the problem at hand in reasonable computational times.
146 citations
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TL;DR: In this paper, an examination of the state of the art on biomimetic robotic fishes is presented, underlining the reasons why bio-inspiration can be a winning move and discussing how fish swimming can be the line of sight of the future locomotion technology.
146 citations
Authors
Showing all 6013 results
Name | H-index | Papers | Citations |
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Jonathan I. Epstein | 138 | 1121 | 80975 |
Antoni Ribas | 132 | 660 | 99227 |
Francesco Fiori | 128 | 1032 | 76699 |
Claudio Franceschi | 120 | 856 | 59868 |
Robert E. Coleman | 103 | 724 | 49796 |
Carmine Zoccali | 99 | 813 | 36774 |
Massimo Falconi | 94 | 667 | 41966 |
Mario Plebani | 91 | 1329 | 43055 |
Roberto Danovaro | 84 | 415 | 23735 |
Rodolfo Montironi | 83 | 958 | 30957 |
Diego Centonze | 81 | 463 | 22857 |
Saverio Cinti | 78 | 256 | 32760 |
Michele Brignole | 76 | 399 | 26758 |
Jürgen P. Rabe | 76 | 391 | 20174 |
Jean-Jacques Body | 70 | 384 | 19608 |