Marche Polytechnic University

About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Prostate cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.

Effects of Permanent Pacemaker and Oral Theophylline in Sick Sinus Syndrome The THEOPACE Study: A Randomized Controlled Trial

Abstract: Background Pacemakers and theophylline are currently being used to relieve symptoms in patients with sick sinus syndrome (SSS). However, the impact of either therapy on the natural course of the disease is unknown. We conducted a randomized controlled trial to prospectively assess the effects of pacemakers and theophylline in patients with SSS. Methods and Results One hundred seven patients with symptomatic SSS (age, 73±11 years) were randomized to no treatment (control group, n=35), oral theophylline (n=36), or dual-chamber rate-responsive pacemaker therapy (n=36). They were followed for up to 48 months (mean, 19±14 months). During follow-up, the occurrence of syncope was lower in the pacemaker group than in the control group (P=.02) and tended to be lower than in the theophylline group (P=.07). Heart failure occurred less often in patients assigned to pacemaker therapy and theophylline than in control patients (both, P=.05), whereas the incidence of sustained paroxysmal tachyarrhythmias, permanent atria...

Bread enriched with cricket powder (Acheta domesticus): A technological, microbiological and nutritional evaluation

Abstract: Recently, the high nutritional value of edible insects attracted the attention of researchers and food industry for their potential use in foods with enhanced nutritional characteristics. In this study cricket (Acheta domesticus) powder was added to wheat flour to obtain bread with enhanced nutritional value. Bread loaves were obtained from doughs produced using different blends of wheat flour and cricket powder added in amounts of 10 or 30% (based on wheat flour) and baker's yeast and/or sourdough. Raw materials, doughs and breads were subjected to technological, microbiological, chemical and sensory analyses. Overall, a negative linear correlation between the amount of added cricket powder and the dough technological parameters was seen. However, compared to control breads produced with the sole wheat flour, breads containing cricket powder showed a higher nutritional profile in terms of fatty acid composition, high protein content and occurrence of essential amino acids. Finally, bread enriched with 10% cricket powder showed a discrete global liking by untrained panelists. Data overall collected highlighted a good suitability of cricket powder for the production of enriched bread. Of note, the presence of spore-forming bacteria in cricket-based bread loaves, thus highlighting potential safety issues to be deepened. Industrial relevance The present study demonstrated that edible insects powder can successfully be included in leavened baked goods to enhance their protein content. The present research also responds to the growing awareness of consumers towards innovative and wholesome leavened goods, proving that edible insects can constitute a novel source of innovative ingredients to be used in bread making.

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Abstract: Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a Pten loss-driven mouse model of prostate cancer through the induction of apoptosis and proliferation block. Conversely, this response is bypassed with deletion of either Trp53 or Zbtb7a together with Pten, leading to the development of castration-resistant prostate cancer (CRPC). Mechanistically, the integrated acquisition of data from mouse models and patients identifies the expression patterns of XAF1, XIAP and SRD5A1 as a predictive and actionable signature for CRPC. Notably, we show that combined inhibition of XIAP, SRD5A1 and AR pathways overcomes castration resistance. Thus, our co-clinical approach facilitates the stratification of patients and the development of tailored and innovative therapeutic treatments.

Evidence for Common Clonal Origin of Multifocal Lung Cancers

Abstract: Methods We analyzed 70 lung tumors from 30 patients (23 females and seven males) who underwent surgical resection for lung epithelial tumors, of whom 26 had non – small cell carcinomas and four had carcinoid/ atypical carcinoid tumors. All patients had multiple tumors (two to five) involving one or both lungs. Genomic DNA was extracted from paraffin-embedded tissue sections using laser capture microdissection and analyzed for loss of heterozygosity, TP53 mutations, and X-chromosome inactivation status. The percentage (95% confidence interval [CI]) of patients in whom there were concordant patterns of genetic alteration was calculated. Results All 30 case subjects showed loss of heterozygosity (LOH) in at least one and at most four of the six polymorphic microsatellite markers. Completely concordant LOH patterns between synchronous and metachronous cancers in individual patients were seen in 26 (87%) of 30 informative patients (95% CI = 75% to 99%). Identical point mutations were present in eight of 10 patients who exhibited TP53 mutation by sequencing. Tumors in 18 (78%) of 23 female patients (95% CI = 67% to 98%) showed identical X-chromosome inactivation patterns. Combining the results of LOH studies, TP53 mutation screening analyses, and X-chromosome inactivation data, we demonstrated that the multiple separate tumors in 23 (77%) of 30 patients (95% CI = 62% to 92%) had identical genetic changes, consistent with monoclonal origin of the separate tumors. Conclusions Our data indicate that the great majority of multifocal lung cancers have a common clonal origin and that multifocality in lung cancer represents local and regional intrapulmonary metastasis.