Institution
Martin Luther University of Halle-Wittenberg
Education•Halle, Germany•
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.
Papers published on a yearly basis
Papers
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TL;DR: This study supports the early use of TIPS in patients with cirrhosis and a high-risk variceal bleeding by confirming results in clinical practice in the same centers of the RCT study.
228 citations
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TL;DR: It is concluded that mutations in EFNB1 cause CFNS, a X-linked craniofacial disorder with an unusual manifestation pattern, in which affected females show multiple skeletal malformations whereas the genetic defect causes no or only mild abnormalities in male carriers.
Abstract: Craniofrontonasal syndrome (CFNS) is an X-linked craniofacial disorder with an unusual manifestation pattern, in which affected females show multiple skeletal malformations, whereas the genetic defect causes no or only mild abnormalities in male carriers. Recently, we have mapped a gene for CFNS in the pericentromeric region of the X chromosome that contains the EFNB1 gene, which encodes the ephrin-B1 ligand for Eph receptors. Since Efnb1 mutant mice display a spectrum of malformations and an unusual inheritance reminiscent of CFNS, we analyzed the EFNB1 gene in three families with CFNS. In one family, a deletion of exons 2–5 was identified in an obligate carrier male, his mildly affected brother, and in the affected females. In the two other families, missense mutations in EFNB1 were detected that lead to amino acid exchanges P54L and T111I. Both mutations are located in multimerization and receptor-interaction motifs found within the ephrin-B1 extracellular domain. In all cases, mutations were found consistently in obligate male carriers, clinically affected males, and affected heterozygous females. We conclude that mutations in EFNB1 cause CFNS.
228 citations
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TL;DR: The authors found that striving for perfection in adolescent school students is associated with positive characteristics and adaptive outcomes and thus may form part of a healthy pursuit of excellence, however, negative reactions to imperfection and perceived parental pressure to be perfect are associated with negative characteristics and maladaptive outcomes, thus may undermine adolescents' motivation and well-being.
228 citations
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TL;DR: In this paper, a large scale benchmark of machine learning methods for the prediction of the thermodynamic stability of solids is presented, which includes all possible perovskite and anti-perovskiite crystals that can be generated with elements from hydrogen to bismuth, excluding rare gases and lanthanides.
Abstract: We perform a large scale benchmark of machine learning methods for the prediction of the thermodynamic stability of solids We start by constructing a data set that comprises density functional theory calculations of around 250000 cubic perovskite systems This includes all possible perovskite and antiperovskite crystals that can be generated with elements from hydrogen to bismuth, excluding rare gases and lanthanides Incidentally, these calculations already reveal a large number of systems (around 500) that are thermodynamically stable but that are not present in crystal structure databases Moreover, some of these phases have unconventional compositions and define completely new families of perovskites This data set is then used to train and test a series of machine learning algorithms to predict the energy distance to the convex hull of stability In particular, we study the performance of ridge regression, random forests, extremely randomized trees (including adaptive boosting), and neural networks
227 citations
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TL;DR: Surface modification of the fungal cell walls by chitin de- N -acetylation is discussed as a fungal strategy to protect cell walls of pathogenic hyphae from enzymatic hydrolysis by host chit inases, and to avoid generation of an auto-catalytic defense response system in the invaded host tissue.
Abstract: Summary
• Conversion of surface-exposed chitin to chitosan in cell walls of in vitro - and in vivo -differentiated infection structures of two rust fungi, the wheat stem rust fungus Puccinia graminis f. sp. tritici and the broad bean rust fungus Uromyces fabae , and of the causal agent of maize anthracnose, Colletotrichum graminicola , were studied.
• Epi-fluorescence microscopy with the fluorescence-labeled lectin wheat germ agglutinin (WGA) revealed that surfaces of infection structures formed on the plant cuticle expose chitin, whereas surfaces of structures formed after invading the host do not.
• To identify chitin modification by de- N -acetylation, we raised polyclonal antibodies specifically recognizing de- N -acetylated chitosan. These antibodies labeled only those infection structures that differentiate inside the plant, indicating that chitosan is exposed on cell wall surfaces post penetration.
• Surface modification of the fungal cell walls by chitin de- N -acetylation is discussed as a fungal strategy to protect cell walls of pathogenic hyphae from enzymatic hydrolysis by host chitinases, and to avoid generation of an auto-catalytic defense response system in the invaded host tissue.
227 citations
Authors
Showing all 20466 results
Name | H-index | Papers | Citations |
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Niels Birbaumer | 142 | 835 | 77853 |
Michael Schmitt | 134 | 2007 | 114667 |
Niels E. Skakkebæk | 127 | 596 | 59925 |
Stefan D. Anker | 117 | 415 | 104945 |
Pedro W. Crous | 115 | 809 | 51925 |
Eric Verdin | 115 | 370 | 47971 |
Bernd Nilius | 112 | 496 | 44812 |
Josep Tabernero | 111 | 803 | 68982 |
Hans-Dieter Volk | 107 | 784 | 46622 |
Dan Rujescu | 106 | 552 | 60406 |
John I. Nurnberger | 105 | 522 | 51402 |
Ulrich Gösele | 102 | 603 | 46223 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Martin F. Bachmann | 100 | 415 | 34124 |
Munir Pirmohamed | 97 | 675 | 39822 |