Martin Luther University of Halle-Wittenberg

About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.

Validierung einer deutschen Version des “Multifactor Leadership Questionnaire“ (MLQ Form 5 x Short) von Bass und Avolio (1995)

Abstract: Zusammenfassung. Vor dem Hintergrund des organisationalen Wandels und veranderter Anforderungen an Fuhrungskrafte werden in der Fuhrungsforschung seit Mitte der 80er Jahre verstarkt Ansatze der charismatischen beziehungsweise transformationalen Fuhrung diskutiert und untersucht. Die meisten empirischen Befunde hierzu basieren auf Erhebungen, bei denen unterschiedliche Versionen des Multifactor Leadership Questionnaire (MLQ) eingesetzt wurden. In diesem Beitrag werden die Ergebnisse von Validierungsuntersuchungen zu einer deutschen, adaptierten Fassung der aktuellen Version 5 x Short des MLQ (Bass & Avolio, 1995) berichtet. Uberpruft wurden die psychometrischen Qualitaten sowie Fragen der Validitat auf der Grundlage unterschiedlicher betrieblicher Stichproben mit uber N = 3500 Befragten. Die gefundene Faktorenstruktur lasst sich im Rahmen des Gesamtmodells interpretieren, wobei die Anzahl der Faktoren etwas von der theoretisch postulierten Vorgabe abweicht. Insgesamt zeigt sich eine gute Konstruktvaliditat...

Collagen Degradation in the Abdominal Aneurysm : A Conspiracy of Matrix Metalloproteinase and Cysteine Collagenases

Abstract: Growth and rupture of abdominal aortic aneurysms (AAAs) result from increased collagen turnover. Collagen turnover critically depends on specific collagenases that cleave the triple helical region of fibrillar collagen. As yet, the collagenases responsible for collagen degradation in AAAs have not been identified. Increased type I collagen degradation products confirmed collagen turnover in AAAs (median values: 80%). We found indications that this secondary deficiency relates to cystatin C degradation by (neutrophil-derived) proteases.

The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severely truncated derivatives of AvrBs4 and overexpressed AvrBs3.

Abstract: The Lycopersicon esculentum Bs4 resistance (R) gene specifies recognition of Xanthomonas campestris pv. vesicatoria (Xcv) strains that express the cognate AvrBs4 avirulence protein. Bs4 was isolated by positional cloning and is predicted to encode a nucleotide-binding leucine-rich repeat (NB-LRR) protein that is homologous to tobacco N and potato Y-1 resistance proteins. Xcv infection tests demonstrate that Bs4 confers perception of AvrBs4 but not the 97% identical AvrBs3 protein. However, when delivered via Agrobacterium T-DNA transfer, both, avrBs4 and avrBs3 trigger a Bs4-dependent hypersensitive response, indicating that naturally occurring AvrBs3-homologues provide a unique experimental platform for molecular dissection of recognition specificity. Transcript studies revealed intron retention in Bs4 transcripts. Yet, an intron-deprived Bs4 derivative still mediates AvrBs4 detection, suggesting that the identified splice variants are not crucial to resistance. The L. pennellii bs4 allele, which is >98% identical to L. esculentum Bs4, has a Bs4-like exon-intron structure with exception of a splice polymorphism in intron 2 that causes truncation of the predicted bs4 protein. To test if the receptor-ligand model is a valid molecular description of Bs4-mediated AvrBs4 perception, we conducted yeast two-hybrid studies. However, a direct interaction was not observed. Defense signaling of the Bs4-governed reaction was studied in Nicotiana benthamiana by virus-induced gene silencing and showed that Bs4-mediated resistance is EDS1- and SGT1-dependent.

Presentation of Hypoparathyroidism: Etiologies and Clinical Features.

Abstract: Context: Understanding the etiology, diagnosis, and symptoms of hypoparathyroidism may help to improve quality of life and long-term disease outcomes. This paper summarizes the results of the findings and recommendations of the Working Group on Presentation of Hypoparathyroidism. Evidence Acquisition: Experts convened in Florence, Italy, in May 2015 and evaluated the literature and recent data on the presentation and long-term outcomes of patients with hypoparathyroidism. Evidence Synthesis: The most frequent etiology is surgical removal or loss of viability of parathyroid glands. Despite precautions and expertise, about 20–30% of patients develop transient and 1–7% develop permanent postsurgical hypoparathyroidism after total thyroidectomy. Autoimmune destruction is the main reason for nonsurgical hypoparathyroidism. Severe magnesium deficiency is an uncommon but correctable cause of hypoparathyroidism. Several genetic etiologies can result in the loss of parathyroid function or action causing isolated h...