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Institution

Martin Luther University of Halle-Wittenberg

EducationHalle, Germany
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.


Papers
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Journal ArticleDOI
TL;DR: Using hen egg white lysozyme as a model protein, data is presented that clearly demonstrate the suppression of the aggregation of denatured protein by l‐Arg.
Abstract: l-Arginine (l-Arg) has been widely used as an enhancer of protein renaturation. The mechanism behind its action is still not fully understood. Using hen egg white lysozyme as a model protein, we present data that clearly demonstrate the suppression of the aggregation of denatured protein by l-Arg. By chemical modification of free cysteines, a series of unfolded lysozyme species were obtained that served as models for unfolded and intermediate states during the process of oxidative refolding. An increased equilibrium solubility of unfolded species and intermediates in the presence of l-Arg seems to be its major mechanism of action.

173 citations

Journal ArticleDOI
TL;DR: The Escherichia coli zitB gene encodes a Zn(II) transporter belonging to the cation diffusion facilitator family and is specifically induced by zinc, suggesting ZitB-mediated efflux of zinc.
Abstract: The Escherichia coli zitB gene encodes a Zn(II) transporter belonging to the cation diffusion facilitator family. ZitB is specifically induced by zinc. ZitB expression on a plasmid rendered zntA-disrupted E. coli cells more resistant to zinc, and the cells exhibited reduced accumulation of 65Zn, suggesting ZitB-mediated efflux of zinc.

172 citations

Journal ArticleDOI
TL;DR: It is shown that Hsp33 harbors two interdependent stress-sensing regions located in the C-terminal redox-switch domain of HSp33: a zinc center sensing peroxide stress conditions and an adjacent linker region responding to unfolding conditions.
Abstract: The redox-regulated chaperone Hsp33 is specifically activated upon exposure of cells to peroxide stress at elevated temperatures. Here we show that Hsp33 harbors two interdependent stress-sensing regions located in the C-terminal redox-switch domain of Hsp33: a zinc center sensing peroxide stress conditions and an adjacent linker region responding to unfolding conditions. Neither of these sensors works sufficiently in the absence of the other, making the simultaneous presence of both stress conditions a necessary requirement for Hsp33's full activation. Upon activation, Hsp33's redox-switch domain adopts a natively unfolded conformation, thereby exposing hydrophobic surfaces in its N-terminal substrate-binding domain. The specific activation of Hsp33 by the oxidative unfolding of its redox-switch domain makes this chaperone optimally suited to quickly respond to oxidative stress conditions that lead to protein unfolding.

172 citations

Journal ArticleDOI
TL;DR: Although the declining trend was remarkably similar across countries, prevalence rates still differed considerably across countries.
Abstract: Background: This study examined trends in adolescent weekly alcohol use between 2002 and 2010 in 28 European and North American countries. Methods: Analyses were based on data from 11-, 13- and 15-year-old adolescents who participated in the Health Behaviour in School-Aged Children (HBSC) study in 2002, 2006 and 2010. Results: Weekly alcohol use declined in 20 of 28 countries and in all geographic regions, from 12.1 to 6.1% in Anglo-Saxon countries, 11.4 to 7.8% in Western Europe, 9.3 to 4.1% in Northern Europe and 16.3 to 9.9% in Southern Europe. Even in Eastern Europe, where a stable trend was observed between 2002 and 2006, weekly alcohol use declined between 2006 and 2010 from 12.3 to 10.1%. The decline was evident in all gender and age subgroups. Conclusions: These consistent trends may be attributable to increased awareness of the harmful effects of alcohol for adolescent development and the implementation of associated prevention efforts, or changes in social norms and conditions. Although the declining trend was remarkably similar across countries, prevalence rates still differed considerably across countries.

172 citations

Book
01 Jan 1999
TL;DR: In this article, the authors develop the theme of estimating dimensions of joins and sets of tangencies, often under assumptions of connectedness, using results from Chapter 3.1 and show as an application of the connectedness theorem that it has no gaps, and this is interpreted in terms of normal cones.
Abstract: In this chapter, we develop the theme of estimating dimensions of joins and sets of tangencies, often under assumptions of connectedness, using results from Chapter 3. In Section 4.1 we study the v-cycle again and show as an application of the connectedness theorem that it has no gaps, and this is interpreted in terms of normal cones. We apply this to linear projections and describe in some cases the structure of such a projection if its image has minimal dimension.

172 citations


Authors

Showing all 20466 results

NameH-indexPapersCitations
Niels Birbaumer14283577853
Michael Schmitt1342007114667
Niels E. Skakkebæk12759659925
Stefan D. Anker117415104945
Pedro W. Crous11580951925
Eric Verdin11537047971
Bernd Nilius11249644812
Josep Tabernero11180368982
Hans-Dieter Volk10778446622
Dan Rujescu10655260406
John I. Nurnberger10552251402
Ulrich Gösele10260346223
Wolfgang J. Parak10246943307
Martin F. Bachmann10041534124
Munir Pirmohamed9767539822
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202397
2022331
20212,038
20202,007
20191,617
20181,604