Institution
Martin Luther University of Halle-Wittenberg
Education•Halle, Germany•
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that metals can be intentionally infiltrated into inner protein structures of biomaterials through multiple pulsed vapor-phase infiltration performed with equipment conventionally used for atomic layer deposition (ALD).
Abstract: In nature, tiny amounts of inorganic impurities, such as metals, are incorporated in the protein structures of some biomaterials and lead to unusual mechanical properties of those materials. A desire to produce these biomimicking new materials has stimulated materials scientists, and diverse approaches have been attempted. In contrast, research to improve the mechanical properties of biomaterials themselves by direct metal incorporation into inner protein structures has rarely been tried because of the difficulty of developing a method that can infiltrate metals into biomaterials, resulting in a metal-incorporated protein matrix. We demonstrated that metals can be intentionally infiltrated into inner protein structures of biomaterials through multiple pulsed vapor-phase infiltration performed with equipment conventionally used for atomic layer deposition (ALD). We infiltrated zinc (Zn), titanium (Ti), or aluminum (Al), combined with water from corresponding ALD precursors, into spider dragline silks and observed greatly improved toughness of the resulting silks. The presence of the infiltrated metals such as Al or Ti was verified by energy-dispersive x-ray (EDX) and nuclear magnetic resonance spectra measured inside the treated silks. This result of enhanced toughness of spider silk could potentially serve as a model for a more general approach to enhance the strength and toughness of other biomaterials.
359 citations
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TL;DR: In this article, the authors compared the performance of different high-pressure homogenization systems with respect to their attainable mean droplet diameter and showed that homogenizers with a relatively simple geometry like the "combined orifice valve" (Kombi-Blende) attain the smallest droplet diameters.
Abstract: Emulsions find a wide range of application in industry and daily life. In the pharmaceutical industry lipophilic active ingredients are often formulated in the disperse phase of oil-in-water emulsions. Milk, butter, and margarine are examples of emulsions in daily life. In the metal processing industry emulsions are used in the form of coolants. Emulsions can be produced with different systems. In the following, the process of high-pressure homogenization is briefly compared to other common mechanical emulsification systems. To facilitate the selection of an emulsification system, the influence of the most important parameters of the emulsion formulation on the resulting mean droplet diameter in the most prevalent continuous emulsification systems is outlined. Subsequently, the most common high-pressure homogenization systems are discussed in detail. On the basis of data from the literature and own experimental results the described high-pressure homogenization systems will be compared regarding their attainable mean droplet diameter. It shows that homogenizers with a relatively simple geometry like the patented “combined orifice valve” (Kombi-Blende) attain the smallest mean droplet diameters. The advantage of the “combined orifice valve” compared to other high-pressure homogenization systems is not more efficient droplet disruption but rather more efficient droplet stabilization against coalescence immediately after the droplet breakup. The greatest research potential concerning the development of new high-pressure homogenization systems is still to be seen in improvements of droplet stabilization, i.e., the reduction of coalescence.
359 citations
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University of Zurich1, Alexander von Humboldt Biological Resources Research Institute2, Lüneburg University3, Dresden University of Technology4, Chinese Academy of Sciences5, Martin Luther University of Halle-Wittenberg6, Leipzig University7, University of Freiburg8, University of Tübingen9, Helmholtz Centre for Environmental Research - UFZ10, East China Normal University11, Wenzhou University12, University of Kiel13, Peking University14, University of Bern15, University of Minnesota16, University of Oxford17, Central South University Forestry and Technology18, Zhejiang University19, Zhejiang Normal University20
TL;DR: The first results from a large biodiversity experiment in a subtropical forest in China suggest strong positive effects of tree diversity on forest productivity and carbon accumulation, and encourage multispecies afforestation strategies to restore biodiversity and mitigate climate change.
Abstract: Biodiversity experiments have shown that species loss reduces ecosystem functioning in grassland. To test whether this result can be extrapolated to forests, the main contributors to terrestrial primary productivity, requires large-scale experiments. We manipulated tree species richness by planting more than 150,000 trees in plots with 1 to 16 species. Simulating multiple extinction scenarios, we found that richness strongly increased stand-level productivity. After 8 years, 16-species mixtures had accumulated over twice the amount of carbon found in average monocultures and similar amounts as those of two commercial monocultures. Species richness effects were strongly associated with functional and phylogenetic diversity. A shrub addition treatment reduced tree productivity, but this reduction was smaller at high shrub species richness. Our results encourage multispecies afforestation strategies to restore biodiversity and mitigate climate change.
359 citations
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TL;DR: The studies demonstrate that human platelets use Clk1-dependent splicing pathways to generate TF protein in response to cellular activation and propose that platelet-derived TF contributes to the propagation and stabilization of a thrombus.
Abstract: Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We now report that quiescent human platelets express TF pre-mRNA and, in response to activation, splice this intronic-rich message into mature mRNA. Splicing of TF pre-mRNA is associated with increased TF protein expression, procoagulant activity, and accelerated formation of clots. Pre-mRNA splicing is controlled by Cdc2-like kinase (Clk)1, and interruption of Clk1 signaling prevents TF from accumulating in activated platelets. Elevated intravascular TF has been reported in a variety of prothrombotic diseases, but there is debate as to whether anucleate platelets—the key cellular effector of thrombosis—express TF. Our studies demonstrate that human platelets use Clk1-dependent splicing pathways to generate TF protein in response to cellular activation. We propose that platelet-derived TF contributes to the propagation and stabilization of a thrombus.
357 citations
Authors
Showing all 20466 results
Name | H-index | Papers | Citations |
---|---|---|---|
Niels Birbaumer | 142 | 835 | 77853 |
Michael Schmitt | 134 | 2007 | 114667 |
Niels E. Skakkebæk | 127 | 596 | 59925 |
Stefan D. Anker | 117 | 415 | 104945 |
Pedro W. Crous | 115 | 809 | 51925 |
Eric Verdin | 115 | 370 | 47971 |
Bernd Nilius | 112 | 496 | 44812 |
Josep Tabernero | 111 | 803 | 68982 |
Hans-Dieter Volk | 107 | 784 | 46622 |
Dan Rujescu | 106 | 552 | 60406 |
John I. Nurnberger | 105 | 522 | 51402 |
Ulrich Gösele | 102 | 603 | 46223 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Martin F. Bachmann | 100 | 415 | 34124 |
Munir Pirmohamed | 97 | 675 | 39822 |