Institution
Martin Luther University of Halle-Wittenberg
Education•Halle, Germany•
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.
Papers published on a yearly basis
Papers
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TL;DR: Cryo-EM is used to structurally characterise brain derived Aβ amyloid fibrils and it is found that they are polymorphic and right-hand twisted, which differs from in vitro generated Aβ fibril.
Abstract: The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer's disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid fibrils from meningeal Alzheimer's brain tissue and their structural analysis with cryo-electron microscopy. We show that these fibrils are polymorphic but consist of similarly structured protofilaments. Brain derived Aβ amyloid fibrils are right-hand twisted and their peptide fold differs sharply from previously analyzed Aβ fibrils that were formed in vitro. These data underscore the importance to use patient-derived amyloid fibrils when investigating the structural basis of the disease.
347 citations
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Université catholique de Louvain1, Université du Québec à Trois-Rivières2, Université Paris-Saclay3, University of Paris4, University of Liège5, Université de Montréal6, Ghent University7, Rutgers University8, Wake Forest University9, Martin Luther University of Halle-Wittenberg10, University of California, Berkeley11, Lawrence Berkeley National Laboratory12, University of Cantabria13, West Virginia University14, Katholieke Universiteit Leuven15, Dalhousie University16
TL;DR: An analysis of the impact that Abinit has had, through for example the bibliometric indicators of the 2009 publication, and the new capabilities of abinit that have been implemented during the last three years are covered, complementing a recent update of the2009 article published in 2016.
347 citations
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TL;DR: DIANA-microT 3.0 was found to achieve the highest precision among the most widely used microRNA target prediction programs reaching approximately 66%.
Abstract: MicroRNAs are small endogenously expressed non-coding RNA molecules that regulate target gene expression through translation repression or messenger RNA degradation. MicroRNA regulation is performed through pairing of the microRNA to sites in the messenger RNA of protein coding genes. Since experimental identification of miRNA target genes poses difficulties, computational microRNA target prediction is one of the key means in deciphering the role of microRNAs in development and disease. DIANA-microT 3.0 is an algorithm for microRNA target prediction which is based on several parameters calculated individually for each microRNA and combines conserved and non-conserved microRNA recognition elements into a final prediction score, which correlates with protein production fold change. Specifically, for each predicted interaction the program reports a signal to noise ratio and a precision score which can be used as an indication of the false positive rate of the prediction. Recently, several computational target prediction programs were benchmarked based on a set of microRNA target genes identified by the pSILAC method. In this assessment DIANA-microT 3.0 was found to achieve the highest precision among the most widely used microRNA target prediction programs reaching approximately 66%. The DIANA-microT 3.0 prediction results are available online in a user friendly web server at http://www.microrna.gr/microT
347 citations
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346 citations
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TL;DR: In this article, the Cosserat-type theories of plates and shells are discussed as a special application of this model, and the authors show that they can explain additional effects in solid and fluid mechanics in a more satisfying manner.
Abstract: One of the research direction of Horst Lippmann during his whole scientific career was devoted to the possibilities to explain complex material behavior by generalized continua models. A representative of such models is the Cosserat continuum. The basic idea of this model is the independence of translations and rotations (and by analogy, the independence of forces and moments). With the help of this model some additional effects in solid and fluid mechanics can be explained in a more satisfying manner. They are established in experiments, but not presented by the classical equations. In this paper the Cosserat-type theories of plates and shells are debated as a special application of the Cosserat theory.
346 citations
Authors
Showing all 20466 results
Name | H-index | Papers | Citations |
---|---|---|---|
Niels Birbaumer | 142 | 835 | 77853 |
Michael Schmitt | 134 | 2007 | 114667 |
Niels E. Skakkebæk | 127 | 596 | 59925 |
Stefan D. Anker | 117 | 415 | 104945 |
Pedro W. Crous | 115 | 809 | 51925 |
Eric Verdin | 115 | 370 | 47971 |
Bernd Nilius | 112 | 496 | 44812 |
Josep Tabernero | 111 | 803 | 68982 |
Hans-Dieter Volk | 107 | 784 | 46622 |
Dan Rujescu | 106 | 552 | 60406 |
John I. Nurnberger | 105 | 522 | 51402 |
Ulrich Gösele | 102 | 603 | 46223 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Martin F. Bachmann | 100 | 415 | 34124 |
Munir Pirmohamed | 97 | 675 | 39822 |