Institution
Martin Luther University of Halle-Wittenberg
Education•Halle, Germany•
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.
Papers published on a yearly basis
Papers
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TL;DR: Threshold tumor diameters for extrathyroidal growth, lymph node spread, and distant metastasis in papillary (PTC) and follicular thyroid carcinoma (FTC) remain to be defined.
Abstract: BACKGROUND
A delay in the diagnosis of differentiated thyroid carcinoma often leads to larger tumors, higher prevalence rates of distant metastasis, and earlier cause-specific deaths. Threshold tumor diameters for extrathyroidal growth, lymph node spread, and distant metastasis in papillary (PTC) and follicular thyroid carcinoma (FTC) remain to be defined.
METHODS
A comparative correlation of primary tumor size and extrathyroidal growth, lymph node spread, and distant metastasis was performed for 500 institutional patients who received surgery for PTC or FTC.
RESULTS
There were 366 patients with PTC (73.2%) and 134 patients with FTC (26.8%). Multifocality (23.5% vs. 9.0%; P 20 mm. Pulmonary metastasis was an earlier event than bone metastasis.
CONCLUSIONS
The data suggested that earlier intervention is warranted to keep suspicious thyroid nodules from growing > 20 mm (or greater than T1) and spreading to distant organs. Cancer 2005. © 2005 American Cancer Society.
318 citations
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Budapest University of Technology and Economics1, ETH Zurich2, Bristol-Myers Squibb3, University College Dublin4, University of Applied Sciences and Arts Northwestern Switzerland FHNW5, Delft University of Technology6, GlaxoSmithKline7, Hunan University8, Newcastle University9, Siemens10, Lappeenranta University of Technology11, Hoffmann-La Roche12, Åbo Akademi University13, University of Helsinki14, Martin Luther University of Halle-Wittenberg15, Massachusetts Institute of Technology16, Université catholique de Louvain17, Nova Southeastern University18, National University of Singapore19, Food and Drug Administration20, FMC Technologies21, University of Tulsa22, Purdue University23
TL;DR: In this paper, a multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and control methods) and presenting applications both in industrial laboratories and in manufacture.
318 citations
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Martin Luther University of Halle-Wittenberg1, Denison University2, University of Helsinki3, University of Aveiro4, University of St Andrews5, Memorial University of Newfoundland6, University of Maine7, University of Edinburgh8, University of Massachusetts Boston9, McGill University10, Leipzig University11, University of Minnesota12, Northern Illinois University13, University of British Columbia14, Université de Sherbrooke15, National Oceanography Centre16
TL;DR: Examining spatial variation in species richness and composition change using more than 50,000 biodiversity time series from 239 studies found clear geographic variation in biodiversity change, suggesting that biodiversity change may be spatially structured.
Abstract: Human activities are fundamentally altering biodiversity. Projections of declines at the global scale are contrasted by highly variable trends at local scales, suggesting that biodiversity change may be spatially structured. Here, we examined spatial variation in species richness and composition change using more than 50,000 biodiversity time series from 239 studies and found clear geographic variation in biodiversity change. Rapid compositional change is prevalent, with marine biomes exceeding and terrestrial biomes trailing the overall trend. Assemblage richness is not changing on average, although locations exhibiting increasing and decreasing trends of up to about 20% per year were found in some marine studies. At local scales, widespread compositional reorganization is most often decoupled from richness change, and biodiversity change is strongest and most variable in the oceans.
318 citations
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TL;DR: In this article, a stochastic interparticle collision model for particle-laden flows to be applied in the frame of the Euler/Lagrange approach is introduced, relying on the generation of a fictitious collision partner with a given size and velocity, whereby no information is required on the actual position and direction of motion of the surrounding real particles.
317 citations
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TL;DR: Hypoxia-independent basal HIF-1α expression in tumor cells, as known from untransformed embryonic stem cells, is sufficient to induce target gene expression, probably including DNA double-strand break repair enzymes.
Abstract: Tumor hypoxia negatively regulates cell growth and causes a more malignant phenotype by increasing the expression of genes encoding angiogenic, metabolic and metastatic factors. Of clinical importance, insufficient tumor oxygenation affects the efficiency of chemotherapy and radiotherapy by poorly understood mechanisms. The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes and HIF-1 is constitutively upregulated in several tumor types. HIF-1 might thus be implicated in tumor therapy resistance. We found that transformed mouse embryonic fibroblasts deficient for HIF-1alpha are more susceptible to the treatment with carboplatin, etoposide and ionizing radiation than wild-type cells. Increased cell death in HIF-1alpha-deficient cells was because of apoptosis and did not involve p53 induction. Tumor chemotherapy of experimental fibrosarcoma in immunocompromised mice with carboplatin and etoposide confirmed the enhanced susceptibility of HIF-1alpha-deficient cells. Agents that did not cause DNA double-strand breaks, such as DNA-synthesis inhibitors or a DNA single-strand break-causing agent equally impaired cell growth, independent of the HIF-1alpha genotype. Functional repair of a fragmented reporter gene was decreased in HIF-1alpha-deficient cells. Thus, hypoxia-independent basal HIF-1alpha expression in tumor cells, as known from untransformed embryonic stem cells, is sufficient to induce target gene expression, probably including DNA double-strand break repair enzymes.
317 citations
Authors
Showing all 20466 results
Name | H-index | Papers | Citations |
---|---|---|---|
Niels Birbaumer | 142 | 835 | 77853 |
Michael Schmitt | 134 | 2007 | 114667 |
Niels E. Skakkebæk | 127 | 596 | 59925 |
Stefan D. Anker | 117 | 415 | 104945 |
Pedro W. Crous | 115 | 809 | 51925 |
Eric Verdin | 115 | 370 | 47971 |
Bernd Nilius | 112 | 496 | 44812 |
Josep Tabernero | 111 | 803 | 68982 |
Hans-Dieter Volk | 107 | 784 | 46622 |
Dan Rujescu | 106 | 552 | 60406 |
John I. Nurnberger | 105 | 522 | 51402 |
Ulrich Gösele | 102 | 603 | 46223 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Martin F. Bachmann | 100 | 415 | 34124 |
Munir Pirmohamed | 97 | 675 | 39822 |