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Institution

Martin Luther University of Halle-Wittenberg

EducationHalle, Germany
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.


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Journal ArticleDOI
TL;DR: The biomineralization of Au nanoparticles in the metallophillic bacterium Cupriavidus metallidurans CH34 is the result of Au-regulated gene expression leading to the energy-dependent reductive precipitation of toxic Au(III)-complexes.
Abstract: While the role of microorganisms as main drivers of metal mobility and mineral formation under Earth surface conditions is now widely accepted, the formation of secondary gold (Au) is commonly attributed to abiotic processes Here we report that the biomineralization of Au nanoparticles in the metallophillic bacterium Cupriavidus metallidurans CH34 is the result of Au-regulated gene expression leading to the energy-dependent reductive precipitation of toxic Au(III)-complexes C metallidurans, which forms biofilms on Au grains, rapidly accumulates Au(III)-complexes from solution Bulk and microbeam synchrotron X-ray analyses revealed that cellular Au accumulation is coupled to the formation of Au(I)-S complexes This process promotes Au toxicity and C metallidurans reacts by inducing oxidative stress and metal resistances gene clusters (including a Au-specific operon) to promote cellular defense As a result, Au detoxification is mediated by a combination of efflux, reduction, and possibly methylation of Au-complexes, leading to the formation of Au(I)-C-compounds and nanoparticulate Au0 Similar particles were observed in bacterial biofilms on Au grains, suggesting that bacteria actively contribute to the formation of Au grains in surface environments The recognition of specific genetic responses to Au opens the way for the development of bioexploration and bioprocessing tools

297 citations

Journal ArticleDOI
TL;DR: The nomenclature system agreed upon by the Chapel Hill Consensus Conference (CHCC) with respect to the terminology and precise definition of the various types of vasculitis has gained widespread interdisciplinary and international acceptance.
Abstract: The nomenclature system agreed upon by the Chapel Hill Consensus Conference (CHCC) with respect to the terminology and precise definition of the various types of vasculitis has gained widespread interdisciplinary and international acceptance. As the revised version from 2012 (CHCC 2012) does not address the special features of vasculitis of the skin, it has recently been supplemented with an addendum containing the nomenclature of cutaneous vasculitides (D-CHCC). The present article provides the German translation of the terms and defintions of the D-CHCC as well as additional explanatory comments. The goal is to enable German-speaking health care providers to more readily apply these defined terms - which are based on interdisciplinary consensus - in everyday clinical practice and to facilitate assessment of their practicability and relevance in patient care. If the majority of cutaneous vasculitides diagnosed can be matched with any of the defined entities presented herein, it might subsequently be possible to develop a classification system and diagnostic algorithms.

296 citations

Journal ArticleDOI
TL;DR: In this article, a maize field trial was established at 1 ha area of a Dystric Cambisol in Brandenburg, NE Germany, where five treatments (control, compost, and three biochar-compost mixtures with constant compost amount (32.5 Mg ha-1) and increasing biochar amount, ranging from 5 −20 Mg Ha-1), were compared.
Abstract: Crop growth in sandy soils is usually limited by plant-available nutrients and water contents. This study was conducted to determine whether these limiting factors could be improved through applications of compost and biochar. For this purpose, a maize (Zea mays L.) field trial was established at 1 ha area of a Dystric Cambisol in Brandenburg, NE Germany. Five treatments (control, compost, and three biochar-compost mixtures with constant compost amount (32.5 Mg ha–1) and increasing biochar amount, ranging from 5–20 Mg ha–1) were compared. Analyses comprised total organic C (TOC), total N (TN), plant-available nutrients, and volumetric soil water content for 4 months under field conditions during the growing season 2009. In addition, soil water-retention characteristics were analyzed on undisturbed soil columns in the laboratory. Total organic-C content could be increased by a factor of 2.5 from 0.8 to 2% (p < 0.01) at the highest biochar-compost level compared with control while TN content only slightly increased. Plant-available Ca, K, P, and Na contents increased by a factor of 2.2, 2.5, 1.2, and 2.8, respectively. With compost addition, the soil pH value significantly increased by up to 0.6 (p < 0.05) and plant-available soil water retention increased by a factor of 2. Our results clearly demonstrated a synergistic positive effect of compost and biochar mixtures on soil organic-matter content, nutrients levels, and water-storage capacity of a sandy soil under field conditions.

296 citations

Journal ArticleDOI
TL;DR: The data imply that repetitive hypoxemia in SAS is probably the cause of the high prevalence of systemic hypertension in this population and that peripheral chemoreceptors and the sympathetic nervous system play important roles in this pathophysiologic process.
Abstract: Background The sleep apnea syndrome (SAS) is a common health problem with a 30% prevalence among patients with so-called essential hypertension. Objective Prompted by this epidemiologic link we tried to find out whether there is a cause-effect relationship between SAS and systemic hypertension. Design We developed an animal model to simulate defined aspects of the SAS. Rats were exposed to chronic repetitive hypoxia for 7 h per day and their blood pressure was measured by invasive methods. Results We found that 30 days of intermittent hypoxia sufficed for the development of a significant elevation of blood pressure. The co-exposure to hypoxia and hypercapnia had no additional effect. Surgical denervation of peripheral chemoreceptors prevented the increase in arterial blood pressure. Adrenal demedullation and chemical denervation of the peripheral sympathetic nervous system by 6-hydroxy dopamine also prevented the increase. Conclusions Our data imply that repetitive hypoxemia in SAS is probably the cause of the high prevalence of systemic hypertension in this population and that peripheral chemoreceptors and the sympathetic nervous system play important roles in this pathophysiologic process.

295 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigated vector-valued parabolic initial boundary value problems with general boundary conditions in domains G in G with compact C 2m -boundary and obtained new trace and extension results for Sobolev spaces of mixed order.
Abstract: In this paper we investigate vector-valued parabolic initial boundary value problems \({(\mathcal A(t,x,D)}\) , \({\mathcal B_j(t,x,D))}\) subject to general boundary conditions in domains G in \({\mathbb R^n}\) with compact C 2m -boundary. The top-order coefficients of \({\mathcal A}\) are assumed to be continuous. We characterize optimal L p -L q -regularity for the solution of such problems in terms of the data. We also prove that the normal ellipticity condition on \({\mathcal A}\) and the Lopatinskii–Shapiro condition on \({(\mathcal A, \mathcal B_1,\dots, \mathcal B_m)}\) are necessary for these L p -L q -estimates. As a byproduct of the techniques being introduced we obtain new trace and extension results for Sobolev spaces of mixed order and a characterization of Triebel-Lizorkin spaces by boundary data.

295 citations


Authors

Showing all 20466 results

NameH-indexPapersCitations
Niels Birbaumer14283577853
Michael Schmitt1342007114667
Niels E. Skakkebæk12759659925
Stefan D. Anker117415104945
Pedro W. Crous11580951925
Eric Verdin11537047971
Bernd Nilius11249644812
Josep Tabernero11180368982
Hans-Dieter Volk10778446622
Dan Rujescu10655260406
John I. Nurnberger10552251402
Ulrich Gösele10260346223
Wolfgang J. Parak10246943307
Martin F. Bachmann10041534124
Munir Pirmohamed9767539822
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202397
2022331
20212,038
20202,007
20191,617
20181,604