Institution
Martin Luther University of Halle-Wittenberg
Education•Halle, Germany•
About: Martin Luther University of Halle-Wittenberg is a education organization based out in Halle, Germany. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 20232 authors who have published 38773 publications receiving 965004 citations. The organization is also known as: MLU & University of Wittenberg.
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Papers
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TL;DR: Metastasectomy nowadays is the best treatment option in cases with technical resectable metastases with as much as possible good prognostic factors (metachronous metastase with long DFI, number up to 6 metastases).
259 citations
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TL;DR: This review covers most of these aspects for the essential micronutrients copper, iron, manganese, molybdenum, nickel, and zinc to provide a broader overview than found in other recent reviews, to cross-link aspects of knowledge in this very active research field.
Abstract: Many trace metals are essential micronutrients, but also potent toxins. Due to natural and anthropogenic causes, vastly different trace metal concentrations occur in various habitats, ranging from deficient to toxic levels. Therefore, one focus of plant research is on the response to trace metals in terms of uptake, transport, sequestration, speciation, physiological use, deficiency, toxicity, and detoxification. In this review, we cover most of these aspects for the essential micronutrients copper, iron, manganese, molybdenum, nickel, and zinc to provide a broader overview than found in other recent reviews, to cross-link aspects of knowledge in this very active research field that are often seen in a separated way. For example, individual processes of metal usage, deficiency, or toxicity often were not mechanistically interconnected. Therefore, this review also aims to stimulate the communication of researchers following different approaches, such as gene expression analysis, biochemistry, or biophysics of metalloproteins. Furthermore, we highlight recent insights, emphasizing data obtained under physiologically and environmentally relevant conditions.
258 citations
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TL;DR: Nine arguments for the dissection course as a central tool for teaching macroscopic anatomy and an attestment to the continuation of the use of cadaver material in anatomical laboratories within the auspices of scholastic and university order for the benefit of future physicians with due respect and honour guaranteed for every donor are presented.
Abstract: Summary Anatomy is a major basic subject in medicine and related biomedical sciences. A central tool most universities use for teaching anatomy is the “dissection course”, in which medical students learn the basic constructional principles of the human body by dissecting a cadaver. In recent years, the relevance and value of the dissection laboratory have been under discussion at different universities due to high costs and problems of shortness in time in some medical curricula. Indeed, during the last 10 years, several universities in the US and the UK have abandoned dissection and have moved from a cadaver-oriented to a cadaverless anatomy. This development results in a fundamental discussion on the role of the “dissection course” in the medical curriculum, ultimately raising the question as to whether we should continue teaching anatomy by dissection. This article presents nine arguments for the dissection course as a central tool for teaching macroscopic anatomy and is an attestment to the continuation of the use of cadaver material in anatomical laboratories within the auspices of scholastic and university order for the benefit of future physicians with due respect and honour guaranteed for every donor.
258 citations
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TL;DR: The aim of this study was to evaluate the effects of olfactory training (OT) onOlfactory function in patients with persistent postinfectious Olfactory dysfunction (PIOD).
Abstract: Objectives/Hypothesis: The aim of this study was to evaluate the effects of olfactory training (OT) on olfactory function in patients with persistent postinfectious olfactory dysfunction (PIOD). Study Design: Randomized, single-blind, controlled, multicenter crossover study. Methods: Twelve tertiary university medical centers participated. Investigations were performed at three visits (base- line, after 18 weeks, and after 36 weeks), including only subjects with PIOD of <24-months duration. At each visit, partici- pants received detailed assessment of olfactory function. Seventy subjects trained with high concentrations of four odors for 18 weeks; the other half (n 5 74) trained with low concentrations of odors. For the following 18 weeks this regimen was switched. Results: After 18 weeks, olfactory function improved in the high-training group in 18 of 70 participants (26%), whereas only 11/74 improved in the low-training group (15%). In subjects with a duration of olfactory dysfunction of <12 months, olfactory function improved in 15/24 participants (63%) of the high-training group and in 6/31 participants (19%) of the low-training group (P 5.03). Conclusions: OT improves PIOD, and the use of odors at higher concentrations is beneficial to improvement. OT is a safe procedure and appears to be particularly useful in patients who start OT within 12 months after the onset of the disor- der. OT is the first successful therapy regime in patients with PIOD.
258 citations
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TL;DR: In this paper, the authors synthesize the growing body of literature on ecosystem services relationships and identify the following four main study objectives: identification and characterization of co-occurrences of ES, identification of drivers that shape ES relationships, exploration of biophysical constraints of landscapes and limitations to their multifunctionality, and support of environmental planning, management and policy decisions.
Abstract: Ecosystem services (ES), the benefits that humans obtain from nature, are of great importance for human well-being. The challenge of meeting the growing human demands for natural resources while sustaining essential ecosystem functions and resilience requires an in-depth understanding of the complex relationships between ES. These conflicting (‘trade-offs’) or synergistic (‘synergies’) relationships mean that changes in one ES can cause changes in other ES. By synthesizing the growing body of literature on ES relationships, we identified the following four main study objectives: (i) the identification and characterization of co-occurrences of ES, (ii) the identification of drivers that shape ES relationships, (iii) the exploration of biophysical constraints of landscapes and limitations to their multifunctionality, and (iv) the support of environmental planning, management and policy decisions. For each of these objectives we here describe the key concepts, including viewpoints of different disciplines, and highlight the major challenges that need to be addressed. We identified three cross-cutting themes being relevant to all four main types of studies. To help guiding researchers towards more systematic analyses of ES trade-offs and synergies, we conclude with an outlook on suggested future research priorities.
258 citations
Authors
Showing all 20466 results
Name | H-index | Papers | Citations |
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Niels Birbaumer | 142 | 835 | 77853 |
Michael Schmitt | 134 | 2007 | 114667 |
Niels E. Skakkebæk | 127 | 596 | 59925 |
Stefan D. Anker | 117 | 415 | 104945 |
Pedro W. Crous | 115 | 809 | 51925 |
Eric Verdin | 115 | 370 | 47971 |
Bernd Nilius | 112 | 496 | 44812 |
Josep Tabernero | 111 | 803 | 68982 |
Hans-Dieter Volk | 107 | 784 | 46622 |
Dan Rujescu | 106 | 552 | 60406 |
John I. Nurnberger | 105 | 522 | 51402 |
Ulrich Gösele | 102 | 603 | 46223 |
Wolfgang J. Parak | 102 | 469 | 43307 |
Martin F. Bachmann | 100 | 415 | 34124 |
Munir Pirmohamed | 97 | 675 | 39822 |