Showing papers by "Massachusetts Institute of Technology published in 1998"
TL;DR: In this article, the optical properties of submicrometre cylindrical cavities in metallic films were explored and it was shown that arrays of such holes display highly unusual zero-order transmission spectra at wavelengths larger than the array period, beyond which no diffraction occurs.
Abstract: The desire to use and control photons in a manner analogous to the control of electrons in solids has inspired great interest in such topics as the localization of light, microcavity quantum electrodynamics and near-field optics1,2,3,4,5,6. A fundamental constraint in manipulating light is the extremely low transmittivity of apertures smaller than the wavelength of the incident photon. While exploring the optical properties of submicrometre cylindrical cavities in metallic films, we have found that arrays of such holes display highly unusual zero-order transmission spectra (where the incident and detected light are collinear) at wavelengths larger than the array period, beyond which no diffraction occurs. In particular, sharp peaks in transmission are observed at wavelengths as large as ten times the diameter of the cylinders. At these maxima the transmission efficiency can exceed unity (when normalized to the area of the holes), which is orders of magnitude greater than predicted by standard aperture theory. Our experiments provide evidence that these unusual optical properties are due to the coupling of light with plasmons — electronic excitations — on the surface of the periodically patterned metal film. Measurements of transmission as a function of the incident light angle result in a photonic band diagram. These findings may find application in novel photonic devices.
7,316 citations
TL;DR: In this paper, the kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells.
Abstract: Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells. Cytochrome c-induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts from cells expressing either active Ras or Akt. Akt phosphorylated recombinant Casp9 in vitro on serine-196 and inhibited its protease activity. Mutant pro-Casp9(Ser196Ala) was resistant to Akt-mediated phosphorylation and inhibition in vitro and in cells, resulting in Akt-resistant induction of apoptosis. Thus, caspases can be directly regulated by protein phosphorylation.
3,280 citations
TL;DR: Evidence is presented that a particular area within human parahippocampal cortex is involved in a critical component of navigation: perceiving the local visual environment, and it is proposed that the PPA represents places by encoding the geometry of the local environment.
Abstract: Medial temporal brain regions such as the hippocampal formation and parahippocampal cortex have been generally implicated in navigation and visual memory. However, the specific function of each of these regions is not yet clear. Here we present evidence that a particular area within human parahippocampal cortex is involved in a critical component of navigation: perceiving the local visual environment. This region, which we name the 'parahippocampal place area' (PPA), responds selectively and automatically in functional magnetic resonance imaging (fMRI) to passively viewed scenes, but only weakly to single objects and not at all to faces. The critical factor for this activation appears to be the presence in the stimulus of information about the layout of local space. The response in the PPA to scenes with spatial layout but no discrete objects (empty rooms) is as strong as the response to complex meaningful scenes containing multiple objects (the same rooms furnished) and over twice as strong as the response to arrays of multiple objects without three-dimensional spatial context (the furniture from these rooms on a blank background). This response is reduced if the surfaces in the scene are rearranged so that they no longer define a coherent space. We propose that the PPA represents places by encoding the geometry of the local environment.
2,842 citations
TL;DR: A large-scale survey for SNPs was examined by a combination of gel-based sequencing and high-density variation-detection DNA chips, and a genetic map was constructed showing the location of 2227 candidate SNPs.
Abstract: Single-nucleotide polymorphisms (SNPs) are the most frequent type of variation in the human genome, and they provide powerful tools for a variety of medical genetic studies. In a large-scale survey for SNPs, 2.3 megabases of human genomic DNA was examined by a combination of gel-based sequencing and high-density variation-detection DNA chips. A total of 3241 candidate SNPs were identified. A genetic map was constructed showing the location of 2227 of these SNPs. Prototype genotyping chips were developed that allow simultaneous genotyping of 500 SNPs. The results provide a characterization of human diversity at the nucleotide level and demonstrate the feasibility of large-scale identification of human SNPs.
2,383 citations
TL;DR: Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.
Abstract: Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are quite large (approximately 100–300 nm in diameter) An understanding of the functional size and physiological regulation of transvascular pathways is necessary to optimize delivery of these agents Here we analyze the functional limits of transvascular transport and its modulation by the microenvironment One human and five murine tumors including mammary and colorectal carcinomas, hepatoma, glioma, and sarcoma were implanted in the dorsal skin-fold chamber or cranial window, and the pore cutoff size, a functional measure of transvascular gap size, was determined The microenvironment was modulated: (i) spatially, by growing tumors in subcutaneous or cranial locations and (ii) temporally, by inducing vascular regression in hormone-dependent tumors Tumors grown subcutaneously exhibited a characteristic pore cutoff size ranging from 200 nm to 12 μm This pore cutoff size was reduced in tumors grown in the cranium or in regressing tumors after hormone withdrawal Vessels induced in basic fibroblast growth factor-containing gels had a pore cutoff size of 200 nm Albumin permeability was independent of pore cutoff size These results have three major implications for the delivery of therapeutic agents: (i) delivery may be less efficient in cranial tumors than in subcutaneous tumors, (ii) delivery may be reduced during tumor regression induced by hormonal ablation, and (iii) permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter
2,340 citations
Journal Article•
TL;DR: When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible.
Abstract: When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible. This has provided the impetus for active study of the design of degradable materials, intelligent delivery systems and approaches for delivery through different portals in the body.
2,195 citations
TL;DR: The crystal structure of this complex, composed of the peptides N36 and C34, is a six-helical bundle that shows striking similarity to the low-pH-induced conformation of influenza hemagglutinin and likely represents the core of fusion-active gp41.
2,162 citations
TL;DR: The authors compare the results of Eulerian hydrodynamic simulations of cluster formation against virial scaling relations between four bulk quantities: the cluster mass, the dark matter velocity dispersion, the gas temperature, and the cluster luminosity.
Abstract: We compare the results of Eulerian hydrodynamic simulations of cluster formation against virial scaling relations between four bulk quantities: the cluster mass, the dark matter velocity dispersion, the gas temperature, and the cluster luminosity. The comparison is made for a large number of clusters at a range of redshifts in three different cosmological models (cold plus hot dark matter, cold dark matter, and open cold dark matter). We find that the analytic formulae provide a good description of the relations between three of the four numerical quantities. The fourth (luminosity) also agrees once we introduce a procedure to correct for the fixed numerical resolution. We also compute the normalizations for the virial relations and compare extensively to the existing literature, finding remarkably good agreement. The Press-Schechter prescription is calibrated with the simulations, again finding results consistent with other authors. We also examine related issues such as the size of the scatter in the virial relations, the effect of metallicity with a fixed passband, and the structure of the halos. All of this is done in order to establish a firm groundwork for the use of clusters as cosmological probes. Implications for the models are briefly discussed.
2,018 citations
TL;DR: An example-based learning approach for locating vertical frontal views of human faces in complex scenes and shows empirically that the distance metric adopted for computing difference feature vectors, and the "nonface" clusters included in the distribution-based model, are both critical for the success of the system.
Abstract: We present an example-based learning approach for locating vertical frontal views of human faces in complex scenes. The technique models the distribution of human face patterns by means of a few view-based "face" and "nonface" model clusters. At each image location, a difference feature vector is computed between the local image pattern and the distribution-based model. A trained classifier determines, based on the difference feature vector measurements, whether or not a human face exists at the current image location. We show empirically that the distance metric we adopt for computing difference feature vectors, and the "nonface" clusters we include in our distribution-based model, are both critical for the success of our system.
2,013 citations
TL;DR: The authors suggests that the rapid increase in the proportion of college graduates in the United States labor force in 1970s may have been a causal factor in both the decline in the college premium during the 1970s and the large increase in inequality during the 1980s.
Abstract: A high proportion of skilled workers in the labor force implies a large market size for skill-complementary technologies, and encourages faster upgrading of the productivity of skilled workers. As a result, an increase in the supply of skills reduces the skill premium in the short run, but then it induces skill-biased technical change and increases the skill premium, possibly even above its initial value. This theory suggests that the rapid increase in the proportion of college graduates in the United States labor force in the 1970s may have been a causal factor in both the decline in the college premium during the 1970s and the large increase in inequality during the 1980s.
2,000 citations
TL;DR: The SPLT is shown to explain a wide range of processing complexity phenomena not previously accounted for under a single theory, including the lower complexity of subject-extraction relative clauses compared to object-extracted relative clauses.
TL;DR: Using the Levitus climatology, the authors showed that 2.1 TW (terawatts) is required to maintain the global abyssal density distribution against 30 Sverdrups of deep water formation.
TL;DR: This work describes schemes that enable a user to access k replicated copies of a database and privately retrieve information stored in the database, so that each individual server gets no information on the identity of the item retrieved by the user.
Abstract: Publicly accessible databases are an indispensable resource for retrieving up-to-date information. But they also pose a significant risk to the privacy of the user, since a curious database operator can follow the user's queries and infer what the user is after. Indeed, in cases where the users' intentions are to be kept secret, users are often cautious about accessing the database. It can be shown that when accessing a single database, to completely guarantee the privacy of the user, the whole database should be down-loaded; namely n bits should be communicated (where n is the number of bits in the database).In this work, we investigate whether by replicating the database, more efficient solutions to the private retrieval problem can be obtained. We describe schemes that enable a user to access k replicated copies of a database (k≥2) and privately retrieve information stored in the database. This means that each individual server (holding a replicated copy of the database) gets no information on the identity of the item retrieved by the user. Our schemes use the replication to gain substantial saving. In particular, we present a two-server scheme with communication complexity O(n1/3).
12 May 1998
TL;DR: An adaptive FFT program that tunes the computation automatically for any particular hardware, and tests show that FFTW's self-optimizing approach usually yields significantly better performance than all other publicly available software.
Abstract: FFT literature has been mostly concerned with minimizing the number of floating-point operations performed by an algorithm. Unfortunately, on present-day microprocessors this measure is far less important than it used to be, and interactions with the processor pipeline and the memory hierarchy have a larger impact on performance. Consequently, one must know the details of a computer architecture in order to design a fast algorithm. In this paper, we propose an adaptive FFT program that tunes the computation automatically for any particular hardware. We compared our program, called FFTW, with over 40 implementations of the FFT on 7 machines. Our tests show that FFTW's self-optimizing approach usually yields significantly better performance than all other publicly available software. FFTW also compares favorably with machine-specific, vendor-optimized libraries.
TL;DR: In this paper, the binding energy of the spin singlet has been observed in a single-electron transistor (SET) with only two electrodes and without control over the structure.
Abstract: How localized electrons interact with delocalized electrons is a central question to many problems in sold-state physics1,2,3. The simplest manifestation of this situation is the Kondo effect, which occurs when an impurity atom with an unpaired electron is placed in a metal2. At low temperatures a spin singlet state is formed between the unpaired localized electron and delocalized electrons at the Fermi energy. Theories predict4,5,6,7 that a Kondo singlet should form in a single-electron transistor (SET), which contains a confined ‘droplet’ of electrons coupled by quantum-mechanical tunnelling to the delocalized electrons in the transistor's leads. If this is so, a SET could provide a means of investigating aspects of the Kondo effect under controlled circumstances that are not accessible in conventional systems: the number of electrons can be changed from odd to even, the difference in energy between the localized state and the Fermi level can be tuned, the coupling to the leads can be adjusted, voltage differences can be applied to reveal non-equilibrium Kondo phenomena7, and a single localized state can be studied rather than a statistical distribution. But for SETs fabricated previously, the binding energy of the spin singlet has been too small to observe Kondo phenomena. Ralph and Buhrman8 have observed the Kondo singlet at a single accidental impurity in a metal point contact, but with only two electrodes and without control over the structure they were not able to observe all of the features predicted. Here we report measurements on SETs smaller than those made previously, which exhibit all of the predicted aspects of the Kondo effect in such a system.
TL;DR: For the period 1975 through 1995, the difference between the average returns on global portfolios of high and low book-to-market stocks is 7.68 percent per year, and value stocks outperform growth stocks in twelve of thirteen major markets.
Abstract: Value stocks have higher returns than growth stocks in markets around the world. For the period 1975 through 1995, the difference between the average returns on global portfolios of high and low book-to-market stocks is 7.68 percent per year, and value stocks outperform growth stocks in twelve of thirteen major markets. An international capital asset pricing model cannot explain the value premium, but a two-factor model that includes a risk factor for relative distress captures the value premium in international returns.
TL;DR: In this paper, two such resonances have been observed in optically trapped Bose-Einstein condensates of sodium atoms by varying an external magnetic field, which gave rise to enhanced inelastic processes and a dispersive variation of the scattering length by a factor of over ten.
Abstract: It has long been predicted that the scattering of ultracold atoms can be altered significantly through a so-called ‘Feshbach resonance’. Two such resonances have now been observed in optically trapped Bose–Einstein condensates of sodium atoms by varying an external magnetic field. They gave rise to enhanced inelastic processes and a dispersive variation of the scattering length by a factor of over ten. These resonances open new possibilities for the study and manipulation of Bose–Einstein condensates.
Proceedings Article•
01 Dec 1998TL;DR: A natural way of achieving this combination by deriving kernel functions for use in discriminative methods such as support vector machines from generative probability models is developed.
Abstract: Generative probability models such as hidden Markov models provide a principled way of treating missing information and dealing with variable length sequences. On the other hand, discriminative methods such as support vector machines enable us to construct flexible decision boundaries and often result in classification performance superior to that of the model based approaches. An ideal classifier should combine these two complementary approaches. In this paper, we develop a natural way of achieving this combination by deriving kernel functions for use in discriminative methods such as support vector machines from generative probability models. We provide a theoretical justification for this combination as well as demonstrate a substantial improvement in the classification performance in the context of DNA and protein sequence analysis.
04 Jan 1998
TL;DR: A general trainable framework for object detection in static images of cluttered scenes based on a wavelet representation of an object class derived from a statistical analysis of the class instances and a motion-based extension to enhance the performance of the detection algorithm over video sequences is presented.
Abstract: This paper presents a general trainable framework for object detection in static images of cluttered scenes. The detection technique we develop is based on a wavelet representation of an object class derived from a statistical analysis of the class instances. By learning an object class in terms of a subset of an overcomplete dictionary of wavelet basis functions, we derive a compact representation of an object class which is used as an input to a support vector machine classifier. This representation overcomes both the problem of in-class variability and provides a low false detection rate in unconstrained environments. We demonstrate the capabilities of the technique in two domains whose inherent information content differs significantly. The first system is face detection and the second is the domain of people which, in contrast to faces, vary greatly in color, texture, and patterns. Unlike previous approaches, this system learns from examples and does not rely on any a priori (hand-crafted) models or motion-based segmentation. The paper also presents a motion-based extension to enhance the performance of the detection algorithm over video sequences. The results presented here suggest that this architecture may well be quite general.
TL;DR: It is proved that no MAX SNP-hard problem has a polynomial time approximation scheme, unless NP = P, and there exists a positive ε such that approximating the maximum clique size in an N-vertex graph to within a factor of Nε is NP-hard.
Abstract: We show that every language in NP has a probablistic verifier that checks membership proofs for it using logarithmic number of random bits and by examining a constant number of bits in the proof. If a string is in the language, then there exists a proof such that the verifier accepts with probability 1 (i.e., for every choice of its random string). For strings not in the language, the verifier rejects every provided “proof” with probability at least 1/2. Our result builds upon and improves a recent result of Arora and Safra [1998] whose verifiers examine a nonconstant number of bits in the proof (though this number is a very slowly growing function of the input length).As a consequence, we prove that no MAX SNP-hard problem has a polynomial time approximation scheme, unless NP = P. The class MAX SNP was defined by Papadimitriou and Yannakakis [1991] and hard problems for this class include vertex cover, maximum satisfiability, maximum cut, metric TSP, Steiner trees and shortest superstring. We also improve upon the clique hardness results of Feige et al. [1996] and Arora and Safra [1998] and show that there exists a positive e such that approximating the maximum clique size in an N-vertex graph to within a factor of Ne is NP-hard.
TL;DR: A superconducting point contact is used to determine the spin polarization at the Fermi energy of several metals because the process of supercurrent conversion at a superconductor-metal interface (Andreev reflection) is limited by the minority spin population near the Fermani surface.
Abstract: A superconducting point contact is used to determine the spin polarization at the Fermi energy of several metals. Because the process of supercurrent conversion at a superconductor-metal interface (Andreev reflection) is limited by the minority spin population near the Fermi surface, the differential conductance of the point contact can reveal the spin polarization of the metal. This technique has been applied to a variety of metals where the spin polarization ranges from 35 to 90 percent: Ni0.8Fe0.2, Ni, Co, Fe, NiMnSb, La0.7Sr0.3MnO3, and CrO2.
TL;DR: These results may be viewed as generalizing the classical Krasovskii theorem, and, more loosely, linear eigenvalue analysis, and the approach is illustrated by controller and observer designs for simple physical examples.
01 May 1998
TL;DR: Cilk-5's novel "two-clone" compilation strategy and its Dijkstra-like mutual-exclusion protocol for implementing the ready deque in the work-stealing scheduler are presented.
Abstract: The fifth release of the multithreaded language Cilk uses a provably good "work-stealing" scheduling algorithm similar to the first system, but the language has been completely redesigned and the runtime system completely reengineered. The efficiency of the new implementation was aided by a clear strategy that arose from a theoretical analysis of the scheduling algorithm: concentrate on minimizing overheads that contribute to the work, even at the expense of overheads that contribute to the critical path. Although it may seem counterintuitive to move overheads onto the critical path, this "work-first" principle has led to a portable Cilk-5 implementation in which the typical cost of spawning a parallel thread is only between 2 and 6 times the cost of a C function call on a variety of contemporary machines. Many Cilk programs run on one processor with virtually no degradation compared to equivalent C programs. This paper describes how the work-first principle was exploited in the design of Cilk-5's compiler and its runtime system. In particular, we present Cilk-5's novel "two-clone" compilation strategy and its Dijkstra-like mutual-exclusion protocol for implementing the ready deque in the work-stealing scheduler.
TL;DR: This work introduces a mathematical model of hybrid systems as interacting collections of dynamical systems, evolving on continuous-variable state spaces and subject to continuous controls and discrete transitions, and develops a theory for synthesizing hybrid controllers for hybrid plants in all optimal control framework.
Abstract: We propose a very general framework that systematizes the notion of a hybrid system, combining differential equations and automata, governed by a hybrid controller that issues continuous-variable commands and makes logical decisions. We first identify the phenomena that arise in real-world hybrid systems. Then, we introduce a mathematical model of hybrid systems as interacting collections of dynamical systems, evolving on continuous-variable state spaces and subject to continuous controls and discrete transitions. The model captures the identified phenomena, subsumes previous models, yet retains enough structure to pose and solve meaningful control problems. We develop a theory for synthesizing hybrid controllers for hybrid plants in all optimal control framework. In particular, we demonstrate the existence of optimal (relaxed) and near-optimal (precise) controls and derive "generalized quasi-variational inequalities" that the associated value function satisfies. We summarize algorithms for solving these inequalities based on a generalized Bellman equation, impulse control, and linear programming.
TL;DR: Recent insights in HIV envelope protein structure and function are reviewed and how these findings lead to new approaches for inhibiting HIV entry and may provide insights into the design of better HIV vaccines are reviewed.
TL;DR: Two real-time hidden Markov model-based systems for recognizing sentence-level continuous American sign language (ASL) using a single camera to track the user's unadorned hands are presented.
Abstract: We present two real-time hidden Markov model-based systems for recognizing sentence-level continuous American sign language (ASL) using a single camera to track the user's unadorned hands. The first system observes the user from a desk mounted camera and achieves 92 percent word accuracy. The second system mounts the camera in a cap worn by the user and achieves 98 percent accuracy (97 percent with an unrestricted grammar). Both experiments use a 40-word lexicon.
TL;DR: The findings suggest the need to reformulate concepts of cAMP-mediated signaling to include direct coupling to Ras superfamily signaling.
Abstract: cAMP (3',5' cyclic adenosine monophosphate) is a second messenger that in eukaryotic cells induces physiological responses ranging from growth, differentiation, and gene expression to secretion and neurotransmission. Most of these effects have been attributed to the binding of cAMP to cAMP-dependent protein kinase A (PKA). Here, a family of cAMP-binding proteins that are differentially distributed in the mammalian brain and body organs and that exhibit both cAMP-binding and guanine nucleotide exchange factor (GEF) domains is reported. These cAMP-regulated GEFs (cAMP-GEFs) bind cAMP and selectively activate the Ras superfamily guanine nucleotide binding protein Rap1A in a cAMP-dependent but PKA-independent manner. Our findings suggest the need to reformulate concepts of cAMP-mediated signaling to include direct coupling to Ras superfamily signaling.
01 Mar 1998
TL;DR: Evidence is presented that robot-aided therapy does not have adverse effects, that patients tolerate the procedure, and that peripheral manipulation of the impaired limb may influence brain recovery, and one approach using kinematic data in a robot- aided assessment procedure.
Abstract: The authors' goal is to apply robotics and automation technology to assist, enhance, quantify, and document neurorehabilitation. This paper reviews a clinical trial involving 20 stroke patients with a prototype robot-aided rehabilitation facility developed at the Massachusetts Institute of Technology, Cambridge, (MIT) and tested at Burke Rehabilitation Hospital, White Plains, NY. It also presents the authors' approach to analyze kinematic data collected in the robot-aided assessment procedure. In particular, they present evidence (1) that robot-aided therapy does not have adverse effects, (2) that patients tolerate the procedure, and (3) that peripheral manipulation of the impaired limb may influence brain recovery. These results are based on standard clinical assessment procedures. The authors also present one approach using kinematic data in a robot-aided assessment procedure.
TL;DR: In this paper, the authors reported data from infrared absorption (FTIR) and X-ray photoelectron spectroscopies that correlate the molecular conformation of oligo(ethylene glycol) (OEG)-terminated self-assembled alkanethiolate monolayers (SAMs) with the ability of these films to resist protein adsorption.
Abstract: We report data from infrared absorption (FTIR) and X-ray photoelectron spectroscopies that correlate the molecular conformation of oligo(ethylene glycol) (OEG)-terminated self-assembled alkanethiolate monolayers (SAMs) with the ability of these films to resist protein adsorption. We studied three different SAMs of alkanethiolates on both evaporated Au and Ag surfaces. The SAMs were formed from substituted 1-undecanethiols with either a hydroxyl-terminated hexa(ethylene glycol) (EG6-OH) or a methoxy-terminated tri(ethylene glycol) (EG3-OMe) end group, or a substituted 1-tridecanethiol chain with a methoxy-terminated tri(ethylene glycol) end group and a −CH2OCH3 side chain at the C-12 atom (EG[3,1]-OMe). The infrared data of EG6-OH-terminated SAMs on both Au and Ag surfaces reveal the presence of a crystalline helical OEG phase, coexisting with amorphous OEG moieties; the EG[3,1]-OMe-terminated alkanethiolates on Au and Ag show a lower absolute coverage and greater disorder than the two other compounds. The...