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Institution

Massachusetts Institute of Technology

EducationCambridge, Massachusetts, United States
About: Massachusetts Institute of Technology is a(n) education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topic(s): Population & Laser. The organization has 116795 authors who have published 268000 publication(s) receiving 18272025 citation(s). The organization is also known as: MIT & M.I.T..
Topics: Population, Laser, Galaxy, Gene, Scattering
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Abstract: Discusses the key role of organizational leadership in organizational culture, and the intertwining problems associated with each. Organizational culture is defined as the basic assumptions and beliefs shared by members of an organization. These are learned, operate unconsciously, and essentially define an organization's view of itself and its environment. Though cultural differences are reflected in companies, each company also has an individual culture that modifies local or national cultures. Origins of culture are discussed, especially the entrepreneur's effect on cultural formation, and mechanisms of embedding and reinforcing cultural standards as a means of guiding an evolving company. Taking an interdisciplinary perspective, the book analyzes the maturing research in the field of organization studies - the available ethnographic methods, participant observation, qualitative research, and clinical research. Results indicate that culture functions to solve an organization's basic problems of (a) surviving in the external environment and (b) integrating its internal processes to ensure its continued survival. Since the organizational structure and people's attitudes and perceptions constitute key artifacts of a culture, both these must be changed before the company's overarching cultural change can occur. Typically, change begins at the formative stage as a positive growth force in need of development, evolves into a complex, diverse model of culture, and finally at the point of maturation, often becomes dysfunctional. It is at this point that the leader-usually the entrepreneur - is most crucial, often turning to various change models as a means of sustaining the company. Though the leader's role in cultural formation shifts, such purposeful, foundational change in an organization only occurs rarely in mature companies and under effective leadership. In sum, cultural leadership - and especially the role of the cultural manager - needs to be assessed more clearly in light of the organization's rapidly changing internal and external environment. (CJC)

13,222 citations


Journal ArticleDOI
15 Jan 2005-Bioinformatics
TL;DR: Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.
Abstract: Summary: Research over the last few years has revealed significant haplotype structure in the human genome. The characterization of these patterns, particularly in the context of medical genetic association studies, is becoming a routine research activity. Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface. Availability: http://www.broad.mit.edu/mpg/haploview/ Contact: jcbarret@broad.mit.edu

13,185 citations


Journal ArticleDOI
Abstract: This paper considers a firm that must issue common stock to raise cash to undertake a valuable investment opportunity. Management is assumed to know more about the firm's value than potential investors. Investors interpret the firm's actions rationally. An equilibrium model of the issue-invest decision is developed under these assumptions. The model shows that firms may refuse to issue stock, and therefore may pass up valuable investment opportunities. The model suggests explanations for several aspects of corporate financing behavior, including the tendency to rely on internal sources of funds, and to prefer debt to equity if external financing is required. Extensions and applications of the model are discussed.

12,954 citations


Journal ArticleDOI
TL;DR: This technique enables the construction of robust key management schemes for cryptographic systems that can function securely and reliably even when misfortunes destroy half the pieces and security breaches expose all but one of the remaining pieces.
Abstract: In this paper we show how to divide data D into n pieces in such a way that D is easily reconstructable from any k pieces, but even complete knowledge of k - 1 pieces reveals absolutely no information about D. This technique enables the construction of robust key management schemes for cryptographic systems that can function securely and reliably even when misfortunes destroy half the pieces and security breaches expose all but one of the remaining pieces.

12,938 citations


Journal ArticleDOI
TL;DR: The Trinity method for de novo assembly of full-length transcripts and evaluate it on samples from fission yeast, mouse and whitefly, whose reference genome is not yet available, providing a unified solution for transcriptome reconstruction in any sample.
Abstract: Massively parallel sequencing of cDNA has enabled deep and efficient probing of transcriptomes. Current approaches for transcript reconstruction from such data often rely on aligning reads to a reference genome, and are thus unsuitable for samples with a partial or missing reference genome. Here we present the Trinity method for de novo assembly of full-length transcripts and evaluate it on samples from fission yeast, mouse and whitefly, whose reference genome is not yet available. By efficiently constructing and analyzing sets of de Bruijn graphs, Trinity fully reconstructs a large fraction of transcripts, including alternatively spliced isoforms and transcripts from recently duplicated genes. Compared with other de novo transcriptome assemblers, Trinity recovers more full-length transcripts across a broad range of expression levels, with a sensitivity similar to methods that rely on genome alignments. Our approach provides a unified solution for transcriptome reconstruction in any sample, especially in the absence of a reference genome.

12,649 citations


Authors

Showing all 116795 results

NameH-indexPapersCitations
Eric S. Lander301826525976
Robert Langer2812324326306
George M. Whitesides2401739269833
Trevor W. Robbins2311137164437
George Davey Smith2242540248373
Yi Cui2201015199725
Robert J. Lefkowitz214860147995
David J. Hunter2131836207050
Daniel Levy212933194778
Rudolf Jaenisch206606178436
Mark J. Daly204763304452
David Miller2032573204840
David Baltimore203876162955
Rakesh K. Jain2001467177727
Ronald M. Evans199708166722
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2022141
202110,566
202011,920
201911,205
201810,883
201710,505

Top Attributes

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Institution's top 5 most impactful journals

Social Science Research Network

5.3K papers, 337.8K citations

Physical Review Letters

3.8K papers, 425.2K citations

The Astrophysical Journal

2.6K papers, 226.6K citations

Nature

2.4K papers, 814.9K citations