Institution
Max Healthcare
Healthcare•New Delhi, India•
About: Max Healthcare is a healthcare organization based out in New Delhi, India. It is known for research contribution in the topics: Population & Cancer. The organization has 391 authors who have published 410 publications receiving 14404 citations.
Topics: Population, Cancer, Infant mortality, Public health, Health care
Papers published on a yearly basis
Papers
More filters
••
Theo Vos1, Amanuel Alemu Abajobir, Kalkidan Hassen Abate2, Cristiana Abbafati3 +775 more•Institutions (305)
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.
10,401 citations
••
Wellcome Trust Centre for Human Genetics1, Imperial College London2, Agency for Science, Technology and Research3, University of Oulu4, National Institutes of Health5, King's College London6, Ealing Hospital7, National University of Singapore8, University of Turin9, University Medical Center Groningen10, University of Tartu11, University of Bristol12, University College London13, University of Eastern Finland14, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico15, University of Kiel16, Leiden University Medical Center17, Dresden University of Technology18, University of Düsseldorf19, University of Surrey20, Erasmus University Rotterdam21, Max Healthcare22, Technische Universität München23, University of Naples Federico II24, Science for Life Laboratory25, Wellcome Trust Sanger Institute26, University of Ulm27, Ludwig Maximilian University of Munich28, University of Kelaniya29, Institute of Cancer Research30, Queen Mary University of London31, King Abdulaziz University32, Massachusetts Institute of Technology33, Health Protection Agency34, Churchill Hospital35, University of Oxford36, Imperial College Healthcare37
TL;DR: In this article, the authors used epigenome-wide association to show that body mass index (BMI), a key measure of adiposity, is associated with widespread changes in DNA methylation.
Abstract: Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances1,2. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation3,4,5,6, a key regulator of gene expression and molecular phenotype7. Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 × 10−7, range P = 9.2 × 10−8 to 6.0 × 10−46; n = 10,261 samples). Genetic association analyses demonstrate that the alterations in DNA methylation are predominantly the consequence of adiposity, rather than the cause. We find that methylation loci are enriched for functional genomic features in multiple tissues (P < 0.05), and show that sentinel methylation markers identify gene expression signatures at 38 loci (P < 9.0 × 10−6, range P = 5.5 × 10−6 to 6.1 × 10−35, n = 1,785 samples). The methylation loci identify genes involved in lipid and lipoprotein metabolism, substrate transport and inflammatory pathways. Finally, we show that the disturbances in DNA methylation predict future development of type 2 diabetes (relative risk per 1 standard deviation increase in methylation risk score: 2.3 (2.07–2.56); P = 1.1 × 10−54). Our results provide new insights into the biologic pathways influenced by adiposity, and may enable development of new strategies for prediction and prevention of type 2 diabetes and other adverse clinical consequences of obesity.
667 citations
••
574 citations
••
TL;DR: This issue of Surgical Endoscopy, the first part of the Guidelines is published including sections on basics, indication for surgery, perioperative management, and key points of technique, and the next part will address complications and comparisons between open and laparoscopic techniques.
Abstract: Guidelines are increasingly determining the decision process in day-to-day clinical work. Guidelines describe the current best possible standard in diagnostics and therapy. They should be developed by an international panel of experts, whereby alongside individual experience, above all, the results of comparative studies are decisive. According to the results of high-ranking scientific studies published in peer-reviewed journals, statements and recommendations are formulated, and these are graded strictly according to the criteria of evidence-based medicine. Guidelines can therefore be valuable in helping particularly the young surgeon in his or her day-to-day work to find the best decision for the patient when confronted with a wide and confusing range of options. However, even experienced surgeons benefit because by virtue of a heavy workload and commitment, they often find it difficult to keep up with the ever-increasing published literature. All guidelines require regular updating, usually every 3 years, in line with progress in the field. The current Guidelines focus on technique and perioperative management of laparoscopic ventral hernia repair and constitute the first comprehensive guidelines on this topic. In this issue of Surgical Endoscopy, the first part of the Guidelines is published including sections on basics, indication for surgery, perioperative management, and key points of technique. The next part (Part 2) of the Guidelines will address complications and comparisons between open and laparoscopic techniques. Part 3 will cover mesh technology, hernia prophylaxis, technique-related issues, new technologic developments, lumbar and other unusual hernias, and training/education.
391 citations
••
University of Oulu1, Imperial College London2, Agency for Science, Technology and Research3, Wellcome Trust Centre for Human Genetics4, University of Milan5, University of Bristol6, National Institutes of Health7, Ealing Hospital8, university of lille9, Pasteur Institute of Lille10, Hammersmith Hospital11, Baker IDI Heart and Diabetes Institute12, National University of Singapore13, French Institute of Health and Medical Research14, Technische Universität München15, University of Kiel16, University of Oxford17, University of Cambridge18, University of Surrey19, Hannover Medical School20, Max Healthcare21, University of Kelaniya22, University of Mauritius23, University of Helsinki24, Imperial College Healthcare25, University of Pennsylvania26, University of Eastern Finland27, University of Düsseldorf28, Dresden University of Technology29, National Institute for Health Research30
TL;DR: A nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population study.
384 citations
Authors
Showing all 396 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pradeep Chowbey | 29 | 118 | 4176 |
Kewal K. Talwar | 29 | 173 | 3502 |
Anil Sharma | 24 | 96 | 1840 |
Manish Baijal | 24 | 80 | 1760 |
Rajesh Khullar | 24 | 89 | 1792 |
Kaushal Madan | 23 | 69 | 2934 |
Joseph L. Mathew | 22 | 224 | 2721 |
Ramandeep Singh Arora | 22 | 83 | 1943 |
Deepak Bansal | 22 | 264 | 2061 |
Divya Agarwal | 22 | 198 | 2020 |
Vandana Soni | 22 | 73 | 1384 |
Deven Juneja | 17 | 65 | 959 |
Rahul Naithani | 17 | 106 | 882 |
Nishkarsh Gupta | 17 | 207 | 1045 |
Abhaya Indrayan | 16 | 99 | 1530 |