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Max Planck Society

NonprofitMunich, Germany
About: Max Planck Society is a(n) nonprofit organization based out in Munich, Germany. It is known for research contribution in the topic(s): Galaxy & Population. The organization has 148289 authors who have published 406224 publication(s) receiving 19522268 citation(s). The organization is also known as: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. & MPG. more

Topics: Galaxy, Population, Star formation more

Showing all 148289 results

Ronald C. Kessler2741332328983
Albert Hofman2672530321405
Graham A. Colditz2611542256034
Michael Grätzel2481423303599
Guido Kroemer2361404246571
George Davey Smith2242540248373
Matthias Mann221887230213
Yi Chen2174342293080
Eric N. Olson206814144586
Ronald M. Evans199708166722
Hans Clevers199793169673
Raymond J. Dolan196919138540
David J. Schlegel193600193972
Simon D. M. White189795231645
George Efstathiou187637156228

Open accessJournal ArticleDOI: 10.1038/NMETH.2019
01 Jul 2012-Nature Methods
Abstract: Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis. Fiji uses modern software engineering practices to combine powerful software libraries with a broad range of scripting languages to enable rapid prototyping of image-processing algorithms. Fiji facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system. We propose Fiji as a platform for productive collaboration between computer science and biology research communities. more

Topics: Software design (51%), Software (50%)

30,888 Citations

Open accessJournal ArticleDOI: 10.1186/S13059-014-0550-8
05 Dec 2014-Genome Biology
Abstract: In comparative high-throughput sequencing assays, a fundamental task is the analysis of count data, such as read counts per gene in RNA-seq, for evidence of systematic changes across experimental conditions. Small replicate numbers, discreteness, large dynamic range and the presence of outliers require a suitable statistical approach. We present DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates. This enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression. The DESeq2 package is available at . more

Topics: MRNA Sequencing (54%), Integrator complex (51%), Count data (50%) more

29,675 Citations

Open accessJournal ArticleDOI: 10.1093/BIOINFORMATICS/BTU170
Anthony Bolger1, Marc Lohse1, Bjoern Usadel1Institutions (1)
01 Aug 2014-Bioinformatics
Abstract: Motivation: Although many next-generation sequencing (NGS) read preprocessing tools already existed, we could not find any tool or combination of tools that met our requirements in terms of flexibility, correct handling of paired-end data and high performance. We have developed Trimmomatic as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data. Results: The value of NGS read preprocessing is demonstrated for both reference-based and reference-free tasks. Trimmomatic is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested. Availability and implementation: Trimmomatic is licensed under GPL V3. It is cross-platform (Java 1.5+ required) and available at Contact: ed.nehcaa-htwr.1oib@ledasu Supplementary information: Supplementary data are available at Bioinformatics online. more

26,464 Citations

Open accessJournal ArticleDOI: 10.1038/35057062
Eric S. Lander1, Lauren Linton1, Bruce W. Birren1, Chad Nusbaum1  +245 moreInstitutions (29)
15 Feb 2001-Nature
Abstract: The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence. more

Topics: Cancer genome sequencing (61%), Hybrid genome assembly (59%), Cancer Genome Project (58%) more

21,023 Citations

Journal ArticleDOI: 10.1007/BF00656997
Owen P. Hamill1, Alain Marty1, Erwin Neher1, Bert Sakmann1  +1 moreInstitutions (1)
Abstract: 1. The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches. 2. A description of a convenient method for the fabrication of patch recording pipettes is given together with procedures followed to achieve giga-seals i.e. pipette-membrane seals with resistances of 10(9) - 10(11) omega. 3. The basic patch clamp recording circuit, and designs for improved frequency response are described along with the present limitations in recording the currents from single channels. 4. Procedures for preparation and recording from three representative cell types are given. Some properties of single acetylcholine-activated channels in muscle membrane are described to illustrate the improved current and time resolution achieved with giga-seals. 5. A description is given of the various ways that patches of membrane can be physically isolated from cells. This isolation enables the recording of single channel currents with well-defined solutions on both sides of the membrane. Two types of isolated cell-free patch configurations can be formed: an inside-out patch with its cytoplasmic membrane face exposed to the bath solution, and an outside-out patch with its extracellular membrane face exposed to the bath solution. 6. The application of the method for the recording of ionic currents and internal dialysis of small cells is considered. Single channel resolution can be achieved when recording from whole cells, if the cell diameter is small (less than 20 micrometer). 7. The wide range of cell types amenable to giga-seal formation is discussed. more

Topics: Automated patch clamp (60%), Voltage clamp (57%), Patch clamp (55%) more

17,019 Citations

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Institution's top 5 most impactful journals

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Physical Review Letters

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