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Institution

Mayo Clinic

HealthcareRochester, Minnesota, United States
About: Mayo Clinic is a healthcare organization based out in Rochester, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 63387 authors who have published 169578 publications receiving 8114006 citations.


Papers
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Journal ArticleDOI
TL;DR: Treatment of atopic dermatitis with nonpharmacologic interventions and pharmacologic topical therapies are reviewed and suggestions on dosing and monitoring are given based on available evidence.
Abstract: Atopic dermatitis is a common and chronic, pruritic inflammatory skin condition that can affect all age groups. This evidence-based guideline addresses important clinical questions that arise in its management. In this second of 4 sections, treatment of atopic dermatitis with nonpharmacologic interventions and pharmacologic topical therapies are reviewed. Where possible, suggestions on dosing and monitoring are given based on available evidence.

889 citations

Journal ArticleDOI
TL;DR: In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually as mentioned in this paper, which is the second most common primary hepatobiliary cancer after hepatocellular cancer.
Abstract: In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually.1 Biliary tract cancer is the second most common primary hepatobiliary cancer, after hepatocellular cancer. Approximately 7500 new cases of biliary tract cancer are diagnosed per year; about 5000 of these are gallbladder cancer, and between 2000 and 3000 are bile-duct cancers.1 Biliary tract cancers have traditionally been divided into cancers of the gallbladder, the extrahepatic bile ducts, and the ampulla of Vater, whereas intrahepatic bile-duct cancers have been classified as primary liver cancers.2 The term “cholangiocarcinoma” was originally intended to refer only . . .

889 citations

Journal ArticleDOI
TL;DR: Alcohol and smoking were significant risk factors for the prevalence of Barrett's esophagus in an adult Swedish population and the prevalence in the general population was found to be 1.6% of the general Swedish population.

888 citations

Journal ArticleDOI
TL;DR: A newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20–27% amino acid identity with other B7family members is described, that may participate in the regulation of cell-mediated immune responses.
Abstract: We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7 family members. B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines. Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin. Soluble B7-H3 protein binds a putative counter-receptor on activated T cells that is distinct from CD28, cytotoxic T lymphocyte antigen 4 (CTLA-4), inducible costimulator (ICOS) and PD-1. B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells, enhances the induction of cytotoxic T cells and selectively stimulates interferon gamma (IFN-gamma) production in the presence of T cell receptor signaling. In contrast, inclusion of antisense B7-H3 oligonucleotides decreases the expression of B7-H3 on DCs and inhibits IFN-gamma production by DC-stimulated allogeneic T cells.Thus, we describe a newly identified costimulatory pathway that may participate in the regulation of cell-mediated immune responses.

887 citations


Authors

Showing all 64325 results

NameH-indexPapersCitations
Eugene Braunwald2301711264576
Peter Libby211932182724
Cyrus Cooper2041869206782
Rob Knight2011061253207
Robert M. Califf1961561167961
Eric J. Topol1931373151025
Dennis W. Dickson1911243148488
Gordon B. Mills1871273186451
Julie E. Buring186950132967
Patrick W. Serruys1862427173210
Cornelia M. van Duijn1831030146009
Paul G. Richardson1831533155912
John C. Morris1831441168413
Valentin Fuster1791462185164
Ronald C. Petersen1781091153067
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023268
20221,216
202112,779
202011,352
201910,004
20188,870