Institution
McGill University
Education•Montreal, Quebec, Canada•
About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.
Topics: Population, Poison control, Health care, Cancer, Receptor
Papers published on a yearly basis
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TL;DR: The CCI summarizes all postoperative complications and is more sensitive than existing morbidity endpoints and may serve as a standardized and widely applicable primary endpoint in surgical trials and other interventional fields of medicine.
Abstract: Objective:To develop and validate a comprehensive complication index (CCI) that integrates all events with their respective severity.Background:Reporting of surgical complications is inconsistent and often incomplete. Most studies fail to provide information about the severity of complications, or i
1,024 citations
TL;DR: Clinicians can make a difference by providing timely and individualised help to families navigating referrals and access to community support systems, by providing accurate information despite often unfiltered media input, and by anticipating transitions such as family changes and school entry and leaving.
1,023 citations
TL;DR: New IGRAs have good specificity and show promise for detecting latent TB, particularly in BCG-vaccinated patients, and in the past decade, 2 new T-cellbased tests for diagnosing latent TB infection have been developed and licensed for commercial distribution in many countries.
Abstract: In this meta-analysis, the authors compared 2 commercially licensed interferon-|gg release assays (IGRAs) with the tuberculin skin test. They found 59 relevant studies. No test distinguished active...
1,023 citations
TL;DR: Evidence is presented for a novel mechanism of disinhibition following peripheral nerve injury that involves a trans-synaptic reduction in the expression of the potassium–chloride exporter KCC2, and the consequent disruption of anion homeostasis in neurons of lamina I of the superficial dorsal horn, one of the main spinal nociceptive output pathways.
Abstract: Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain syndromes. However, the nature of the mechanisms that underlie such disinhibition has remained controversial. Here we present evidence for a novel mechanism of disinhibition following peripheral nerve injury. It involves a trans-synaptic reduction in the expression of the potassium-chloride exporter KCC2, and the consequent disruption of anion homeostasis in neurons of lamina I of the superficial dorsal horn, one of the main spinal nociceptive output pathways. In our experiments, the resulting shift in the transmembrane anion gradient caused normally inhibitory anionic synaptic currents to be excitatory, substantially driving up the net excitability of lamina I neurons. Local blockade or knock-down of the spinal KCC2 exporter in intact rats markedly reduced the nociceptive threshold, confirming that the reported disruption of anion homeostasis in lamina I neurons was sufficient to cause neuropathic pain.
1,023 citations
TL;DR: In this paper, the authors thank Eric Kandel, Richard Morris, Peter Rapp, and Larry Squire for their thoughtful comments and criticisms on versions of this manuscript, which is supported by grants from NIMH and NIA.
1,023 citations
Authors
Showing all 73373 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Karl J. Friston | 217 | 1267 | 217169 |
| Yi Chen | 217 | 4342 | 293080 |
| Yoshua Bengio | 202 | 1033 | 420313 |
| Irving L. Weissman | 201 | 1141 | 172504 |
| Mark I. McCarthy | 200 | 1028 | 187898 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Martin White | 196 | 2038 | 232387 |
| Michael Marmot | 193 | 1147 | 170338 |
| Michael A. Strauss | 185 | 1688 | 208506 |
| Alan C. Evans | 183 | 866 | 134642 |
| Douglas R. Green | 182 | 661 | 145944 |
| David A. Weitz | 178 | 1038 | 114182 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Feng Zhang | 172 | 1278 | 181865 |