McGill University

About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Abstract: Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD-abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions.

Supercapacitor Energy Storage for Wind Energy Applications

Abstract: As wind energy reaches higher penetration levels, there is a greater need to manage intermittency associated with the individual wind turbine generators. This paper considers the integration of a short-term energy storage device in a doubly fed induction generator design in order to smooth the fast wind-induced power variations. This storage device can also be used to reinforce the dc bus during transients, thereby enhancing its low-voltage ride through (LVRT) capability. The topology is evaluated in terms of its ability to improve the performance both during normal operation and during transients. Results show that when storage is sized based upon the LVRT requirement, it can effectively damp short-term power oscillations, and it provides superior transient performance when compared with conventional topologies