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Institution

McGill University

EducationMontreal, Quebec, Canada
About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.


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Journal ArticleDOI
Roy Lyster1
TL;DR: This article investigated the effects of form-focused instruction (FFI) and corrective feedback on immersion students' ability to accurately assign grammatical gender in French and found that FFI is more effective when combined with prompts than with recasts or no feedback, as a means of enabling learners to acquire rule-based representations of grammatical genders and to proceduralize their knowledge of these emerging forms.
Abstract: Four teachers and their eight classes of 179 fifth-grade (10–11-year-old) students participated in this quasi-experimental classroom study, which investigated the effects of form-focused instruction (FFI) and corrective feedback on immersion students' ability to accurately assign grammatical gender in French. The FFI treatment, designed to draw attention to selected noun endings that reliably predict grammatical gender and to provide opportunities for practice in associating these endings with gender attribution, was implemented in the context of regular subject-matter instruction by three of the four teachers, each with two classes, for approximately 9 hours during a 5-week period, while the fourth teacher taught the same subject matter without FFI to two comparison classes. Additionally, each of the three FFI teachers implemented a different feedback treatment: recasts, prompts, or no feedback. Analyses of pretest, immediate-posttest, and delayed-posttest results showed a significant increase in the ability of students exposed to FFI to correctly assign grammatical gender. Results of the written tasks in particular, and to a lesser degree the oral tasks, revealed that FFI is more effective when combined with prompts than with recasts or no feedback, as a means of enabling L2 learners to acquire rule-based representations of grammatical gender and to proceduralize their knowledge of these emerging forms.This study was funded by the Social Sciences and Humanities Research Council of Canada (nos. 410-98-0175 and 410-2002-0988). Parts of this study were presented at the annual meeting of the American Association for Applied Linguistics in Salt Lake City on April 7, 2002; the Congress of the Social Sciences and Humanities in Toronto on May 26, 2002; and at the Congress of the International Association for Applied Linguistics in Singapore on December 12, 2002. I am grateful to the participating teachers and their students, to Lucy Fazio for her role as research associate in the data collection, to Jose Correa for his assistance with the statistical analyses, and to the following research assistants for contributions to various phases of this research: Susan Ballinger, Kristina Eisenhower, Andreanne Gagne, Sophie Beaudoin, Laura-Annie Bouffard, France Bourassa, Sophie Bourgeois, Elisa David, Melanie Mathieu, Sophie Prince, Andrea Sterzuk, and David Syncox. I gratefully acknowledge Leila Ranta, Iliana Panova, and four anonymous SSLA reviewers for their helpful comments on an earlier version of this paper.

777 citations

Journal ArticleDOI
TL;DR: In this paper, the authors provide a comprehensive review of previous literature on the frequency of self-mutilation and preliminary epidemiological data concerning the frequency in a community sample of high schools students.
Abstract: Currently little research exists examining self-mutilation (SM) in community samples of adolescents, despite tentative findings suggesting that self-harming behaviors, including SM may be increasing. The present study provides a comprehensive review of previous literature on the frequency of SM as well as preliminary epidemiological data concerning the frequency of SM in a community sample of high schools students. The relationship between SM, anxiety, and depressive symptomatology was also assessed. Four hundred and forty students from two schools, an urban and a suburban high school, were given a screening measure designed to assess for SM. Students who indicated that they hurt themselves on purpose also participated in a follow-up interview. Based on interviews it was found that 13.9% of all students reported having engaged in SM behavior at some time. Girls reported significantly higher rates of SM than did boys (64 vs. 36%, respectively). Self-cutting was found to be the most common type of SM, followed by self-hitting, pinching, scratching, and biting. Finally, students who self-mutilate reported significantly more anxiety and depressive symptomatology than students who did not self-mutilate. Results are also presented concerning demographic information and patterns of SM behavior.

777 citations

Journal ArticleDOI
TL;DR: In this paper, the locus of control of top executives was found to have a direct and significant relationship to the nature of corporate strategy, but an indirect relationship to environment an...
Abstract: In a Canadian study the locus of control of top executives was found to bear a direct and significant relationship to the nature of corporate strategy but an indirect relationship to environment an...

776 citations

Journal ArticleDOI
David T.W. Jones1, Natalie Jäger1, Marcel Kool1, Thomas Zichner2, Barbara Hutter1, Marc Sultan3, Yoon Jae Cho4, Trevor J. Pugh5, Volker Hovestadt1, Adrian M. Stütz2, Tobias Rausch2, Hans-Jörg Warnatz3, Marina Ryzhova, Sebastian Bender1, Dominik Sturm1, Sabrina Pleier1, Huriye Cin1, Elke Pfaff1, Laura Sieber1, Andrea Wittmann1, Marc Remke1, Hendrik Witt1, Hendrik Witt6, Sonja Hutter1, Theophilos Tzaridis1, Joachim Weischenfeldt2, Benjamin Raeder2, Meryem Avci3, Vyacheslav Amstislavskiy3, Marc Zapatka1, Ursula D. Weber1, Qi Wang1, Bärbel Lasitschka1, Cynthia C. Bartholomae1, Manfred Schmidt1, Christof von Kalle1, Volker Ast1, Chris Lawerenz1, Jürgen Eils1, Rolf Kabbe1, Vladimir Benes2, Peter van Sluis7, Jan Koster7, Richard Volckmann7, David Shih, Matthew J. Betts6, Robert B. Russell6, Simona Coco, Gian Paolo Tonini, Ulrich Schüller8, Volkmar Hans, Norbert Graf9, Yoo-Jin Kim9, Camelia M. Monoranu, Wolfgang Roggendorf, Andreas Unterberg6, Christel Herold-Mende6, Till Milde1, Till Milde6, Andreas E. Kulozik6, Andreas von Deimling6, Andreas von Deimling1, Olaf Witt6, Olaf Witt1, Eberhard Maass, Jochen Rössler, Martin Ebinger, Martin U. Schuhmann, Michael C. Frühwald10, Martin Hasselblatt, Nada Jabado11, Stefan Rutkowski12, André O. von Bueren12, Daniel Williamson13, Steven C. Clifford13, Martin G. McCabe14, Martin G. McCabe15, V. Peter Collins14, Stephan Wolf1, Stefan Wiemann1, Hans Lehrach3, Benedikt Brors1, Wolfram Scheurlen10, Jörg Felsberg16, Guido Reifenberger16, Paul A. Northcott, Michael D. Taylor, Matthew Meyerson5, Matthew Meyerson17, Scott L. Pomeroy5, Scott L. Pomeroy10, Marie-Laure Yaspo3, Jan O. Korbel2, Andrey Korshunov1, Andrey Korshunov6, Roland Eils6, Roland Eils1, Stefan M. Pfister6, Stefan M. Pfister1, Peter Lichter1 
02 Aug 2012-Nature
TL;DR: An integrative deep-sequencing analysis of 125 tumour–normal pairs enhances the understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provides several potential targets for new therapeutics, especially for Group 3 and 4 patients.
Abstract: Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles are currently identified. WNT tumours, showing activated wingless pathway signalling, carry a favourable prognosis under current treatment regimens. SHH tumours show hedgehog pathway activation, and have an intermediate prognosis. Group 3 and 4 tumours are molecularly less well characterized, and also present the greatest clinical challenges. The full repertoire of genetic events driving this distinction, however, remains unclear. Here we describe an integrative deep-sequencing analysis of 125 tumour-normal pairs, conducted as part of the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project. Tetraploidy was identified as a frequent early event in Group 3 and 4 tumours, and a positive correlation between patient age and mutation rate was observed. Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns. RNA sequencing confirmed these alterations, and revealed the expression of what are, to our knowledge, the first medulloblastoma fusion genes identified. Chromatin modifiers were frequently altered across all subgroups. These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients.

775 citations

Journal ArticleDOI
TL;DR: The authors found that political consumerism is primarily a tool of those who are distrustful of political institutions, and political consumers have more trust in other citizens, and they are disproportionately involved in checkbook organizations.
Abstract: Both anecdotal and case-study evidence have long suggested that consumer behavior such as the buying or boycotting of products and services for political and ethical reasons can take on political significance. Despite recent claims that such behavior has become more widespread in recent years, political consumerism has not been studied systematically in survey research on political participation. Through the use of a pilot survey conducted among 1015 Canadian, Belgian, and Swedish students, we ascertain whether political consumerism is a sufficiently consistent behavioral pattern to be measured and studied meaningfully. The data from this pilot survey allow us to build a "political consumerism index" incorporating attitudinal, behavioral, and frequency measurements. Our analysis of this cross-national student sample suggests that political consumerism is primarily a tool of those who are distrustful of political institutions. However, political consumers have more trust in other citizens, and they are disproportionately involved in checkbook organizations. They also tend to score highly on measures of political efficacy and post-materialism. We strongly suggest including measurements of political consumerism together with other emerging forms of activism in future population surveys on political participation.

774 citations


Authors

Showing all 73373 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Yi Chen2174342293080
Yoshua Bengio2021033420313
Irving L. Weissman2011141172504
Mark I. McCarthy2001028187898
Lewis C. Cantley196748169037
Martin White1962038232387
Michael Marmot1931147170338
Michael A. Strauss1851688208506
Alan C. Evans183866134642
Douglas R. Green182661145944
David A. Weitz1781038114182
David L. Kaplan1771944146082
Hyun-Chul Kim1764076183227
Feng Zhang1721278181865
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023342
2022998
20219,055
20208,668
20197,828
20187,237