McGill University

About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.

Variations in the Hypothalamic-Pituitary-Adrenal Response to Stress during the Estrous Cycle in the Rat

Abstract: To investigate the role of gonadal steroids in the hypothalamic-pituitary-adrenal (HPA) response to stress, we studied adrenocorticotrophin (ACTH) and corticosterone (B) responses to 20-min restraint stress in cycling female rats, and in ovariectomized (OVX) rats replaced with physiological levels of estradiol (E2) and progesterone (P). In cycling rats, we found significantly higher peak ACTH (P less than 0.01) and B (P less than 0.05) responses to stress during proestrus compared to the estrous and diestrous phases. No differences were found in either basal ACTH and B levels across the cycle phases. In a separate study, OVX rats were maintained on low, physiological levels of E2 and P with silastic implants for 3 days, and injected either with oil (O'), 10 micrograms of E2 (E') 24 h before stress testing, or with E2 and 500 micrograms P 24 and 4 h, respectively, prior to stress (EP'). These treatments mimicked endogenous profiles of E2 and P occurring during diestrous, proestrous, and late proestrous-early estrous phases, respectively. In response to stress, ACTH levels were higher (P less than 0.01) in the E' group compared to the EP' and O' groups. Although the peak B response was similar in all groups, the E' and EP' groups secreted more B after the termination of stress than did the O' group. Within the 20 min stress period, ACTH levels in the E' group were significantly (P less than 0.05) higher at 5, 10, and 15 min after the onset of stress, compared to the EP' and O' groups. Plasma B levels were significantly higher in the E' group at 5 and 10 min (P less than 0.05 and P less than 0.01, respectively) compared to the EP' and O' group. beta-endorphin-like immunoreactive responses to restraint stress were also significantly higher in the E' group compared to the EP' (P less than 0.05) and O' (P less than 0.01) groups. In contrast to the effect seen at 24 h, ACTH responses to stress 48 h after E2 injection in the E' group were comparable to O' animals. There was no effect of E2 on ACTH clearance, whereas B clearance was enhanced in E' treated animals vs. O'-treated animals. These results indicate that the HPA axis in the female rat is most sensitive to stress during proestrous. Such enhanced HPA responses to stress are limited to the early portion of proestrous, as progesterone appears to inhibit the facilitatory effects of estrogen on ACTH release during stress. Taken together, these results suggest an ovarian influence on both activational and inhibitory components of HPA activity.

Electrodynamics of Magnetars: Implications for the Persistent X-Ray Emission and Spin-down of the Soft Gamma Repeaters and Anomalous X-Ray Pulsars

Abstract: We consider the structure of neutron star magnetospheres threaded by large-scale electrical currents and the effect of resonant Compton scattering by the charge carriers (both electrons and ions) on the emergent X-ray spectra and pulse profiles. In the magnetar model for the soft gamma repeaters (SGRs) and anomalous X-ray pulsars (AXPs), these currents are maintained by magnetic stresses acting deep inside the star, which generate both sudden disruptions (SGR outbursts) and more gradual plastic deformations of the rigid crust. We construct self-similar force-free equilibria of the current-carrying magnetosphere with a power-law dependence of magnetic field on radius, ∝ r-(2+p), and show that a large-scale twist of field lines softens the radial dependence of the magnetic field to p < 1. The spin-down torque acting on the star is thereby increased in comparison with an orthogonal vacuum dipole. We comment on the strength of the surface magnetic field in the SGR and AXP sources, as inferred from their measured spin-down rates, and the implications of this model for the narrow measured distribution of spin periods. A magnetosphere with a strong twist [B/Bθ = O(1) at the equator] has an optical depth ~1 to resonant cyclotron scattering, independent of frequency (radius), surface magnetic field strength, or charge/mass ratio of the scattering charge. When electrons and ions supply the current, the stellar surface is also heated by the impacting charges at a rate comparable to the observed X-ray output of the SGR and AXP sources, if Bdipole ~ 1014 G. Redistribution of the emerging X-ray flux at the cyclotron resonance will strongly modify the emerging pulse profile and, through the Doppler effect, generate a nonthermal tail to the X-ray spectrum. We relate the sudden change in the pulse profile of SGR 1900+14 following the 1998 August 27 giant flare to an enhanced optical depth at the electron cyclotron resonance resulting from a sudden twist imparted to the external magnetic field during the flare. The self-similar structure of the magnetosphere should generate frequency-independent profiles; more complicated pulse profiles may reflect the presence of higher multipoles, ion cyclotron scattering, or possibly nonresonant Compton scattering of O-mode photons by pair-loaded currents.

Good News and Bad News: Asymmetric Responses to Economic Information

Abstract: There is a growing body of work suggesting that responses to positive and negative information are asymmetric—that negative information has a much greater impact on individuals' attitudes than does positive information. This paper explores these asymmetries in mass media responsiveness to positive and negative economic shifts and in public responsiveness to both the economy itself and economic news coverage. Using time-series analyses of U.K. media and public opinion, strong evidence is found of asymmetry. The dynamic is discussed as it applies to political communications and policymaking and more generally to public responsiveness in representative democracies.