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Institution

McGill University

EducationMontreal, Quebec, Canada
About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.


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Journal ArticleDOI
TL;DR: The international system is not only an expression of domestic structures, but a cause of them as discussed by the authors, and two schools of analysis exploring the impact of international system upon domestic politics (regime types, institutions, coalitions, policies) may be distinguished: those that stress the international economy, and those which stress political-military rivalry, or war.
Abstract: The international system is not only an expression of domestic structures, but a cause of them. Two schools of analysis exploring the impact of the international system upon domestic politics (regime types, institutions, coalitions, policies) may be distinguished: those which stress the international economy, and those which stress political-military rivalry, or war. Among the former are such arguments as: late industrialization (associated with Gershenkron); dependencia or core-periphery arguments (Wallerstein); liberal development model (much American writing in the 50s and 60s); transnational relation-modernization (Nye, Keohane, Morse); neo-mercantilists (Gilpin); state-centered Marxists (Schurmann). Arguments stressing the role of war include those which focus on the organizational requirements of providing security (Hintze, Anderson), the special nature of foreign relations (classical political theory), territorial compensation (diplomatic history), and strains of foreign involvement (analysis of revolutions). These arguments provide the basis for criticism of much of the literature which uses domestic structure as an explanation of foreign policy, in particular those which (such as the strong-state weak-state distinction) tend, by excessive focus on forms, to obscure the connection between structures and interests, and the role of politics. These arguments also permit criticism of the notion of a recent fundamental discontinuity in the nature of international relations.

1,298 citations

Journal ArticleDOI
TL;DR: This work developed REVEL (rare exome variant ensemble learner), an ensemble method for predicting the pathogenicity of missense variants on the basis of individual tools: MutPred, FATHMM, VEST, PolyPhen, SIFT, PROVEAN, MutationAssessor, LRT, GERP, SiPhy, phyloP, and phastCons.
Abstract: The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and limited functional data. Improved methods for predicting the pathogenicity of rare coding variants are needed to facilitate the discovery of disease variants from exome sequencing studies. We developed REVEL (rare exome variant ensemble learner), an ensemble method for predicting the pathogenicity of missense variants on the basis of individual tools: MutPred, FATHMM, VEST, PolyPhen, SIFT, PROVEAN, MutationAssessor, MutationTaster, LRT, GERP, SiPhy, phyloP, and phastCons. REVEL was trained with recently discovered pathogenic and rare neutral missense variants, excluding those previously used to train its constituent tools. When applied to two independent test sets, REVEL had the best overall performance (p −12 ) as compared to any individual tool and seven ensemble methods: MetaSVM, MetaLR, KGGSeq, Condel, CADD, DANN, and Eigen. Importantly, REVEL also had the best performance for distinguishing pathogenic from rare neutral variants with allele frequencies

1,295 citations

Journal ArticleDOI
01 May 2007-Scanning
TL;DR: The intent of this software is to assist scanning electron microscope users in interpretation of imaging and microanalysis and also with more advanced procedures including electron-beam lithography.
Abstract: Monte Carlo simulations have been widely used by microscopists for the last few decades. In the beginning it was a tedious and slow process, requiring a high level of computer skills from users and long computational times. Recent progress in the microelectronics industry now provides researchers with affordable desktop computers with clock rates greater than 3 GHz. With this type of computing power routinely available, Monte Carlo simulation is no longer an exclusive or long (overnight) process. The aim of this paper is to present a new user-friendly simulation program based on the earlier CASINO Monte Carlo program. The intent of this software is to assist scanning electron microscope users in interpretation of imaging and microanalysis and also with more advanced procedures including electron-beam lithography. This version uses a new architecture that provides results twice as quickly. This program is freely available to the scientific community and can be downloaded from the website: (www.gel.usherb.ca/casino).

1,295 citations

Journal ArticleDOI
TL;DR: An MNI‐to‐Talairach (MTT) transform to correct for bias between MNI and Talairach coordinates was formulated using a best‐fit analysis in one hundred high‐resolution 3‐D MR brain images.
Abstract: MNI coordinates determined using SPM2 and FSL/FLIRT with the ICBM-152 template were compared to Talairach coordinates determined using a landmark-based Talairach registration method (TAL). Analysis revealed a clear-cut bias in reference frames (origin, orientation) and scaling (brain size). Accordingly, ICBM-152 fitted brains were consistently larger, oriented more nose down, and translated slightly down relative to TAL fitted brains. Whole brain analysis of MNI/Talairach coordi- nate disparity revealed an ellipsoidal pattern with disparity ranging from zero at a point deep within the left hemisphere to greater than 1-cm for some anterior brain areas. MNI/Talairach coordinate dis- parity was generally less for brains fitted using FSL. The mni2tal transform generally reduced MNI/ Talairach coordinate disparity for inferior brain areas but increased disparity for anterior, posterior, and superior areas. Coordinate disparity patterns differed for brain templates (MNI-305, ICBM-152) using the same fitting method (FSL/FLIRT) and for different fitting methods (SPM2, FSL/FLIRT) using the same template (ICBM-152). An MNI-to-Talairach (MTT) transform to correct for bias between MNI and Talairach coordinates was formulated using a best-fit analysis in one hundred high-resolution 3-D MR brain images. MTT transforms optimized for SPM2 and FSL were shown to reduced group mean MNI/Talairach coordinate disparity from a 5-13 mm to 1-2 mm for both deep and superficial brain sites. MTT transforms provide a validated means to convert MNI coordinates to Talairach compatible coordinates for studies using either SPM2 or FSL/FLIRT with the ICBM-152 template. Hum Brain Mapp

1,293 citations

Journal ArticleDOI
TL;DR: Normal anthropometric standards are presented for new-born Caucasian infants at sea level between 25 and 44 weeks' gestational age based upon measurements in 7 dimensions made in duplicate by a single observer using standard measurement techniques.

1,291 citations


Authors

Showing all 73373 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Yi Chen2174342293080
Yoshua Bengio2021033420313
Irving L. Weissman2011141172504
Mark I. McCarthy2001028187898
Lewis C. Cantley196748169037
Martin White1962038232387
Michael Marmot1931147170338
Michael A. Strauss1851688208506
Alan C. Evans183866134642
Douglas R. Green182661145944
David A. Weitz1781038114182
David L. Kaplan1771944146082
Hyun-Chul Kim1764076183227
Feng Zhang1721278181865
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023342
2022998
20219,055
20208,668
20197,828
20187,237